Strain Name:
C57BL/6J-MtgxR5509Btlr/Mmmh
Stock Number:
043070-MU
Citation ID:
RRID:MMRRC_043070-MU
Other Names:
R5509 (G1), C57BL/6J-MtgxR5509Btlr
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Ubc
Name: ubiquitin C
Synonyms: 2700054O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22190
Homologene: 128418
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 30926
Homologene: 4769
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 97287
Homologene: 11203
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: 2610509D04Rik, Ggtb3, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: mNET1, Net1 homolog, 9530071N24Rik, 0610025H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Mdm2
Name: transformed mouse 3T3 cell double minute 2
Synonyms: Mdm-2, 1700007J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17246
HGNC: HGNC:6973
Homologene: 1793
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ankrd13c
Name: ankyrin repeat domain 13c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433667
Homologene: 41804
Sox2
Name: SRY (sex determining region Y)-box 2
Synonyms: Sox-2, lcc, ysb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20674
Homologene: 68298
Ptprm
Name: protein tyrosine phosphatase, receptor type, M
Synonyms: RPTPmu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Napb
Name: N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms: SNARE, b-SNAP, I47, E161, Brp14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17957
Homologene: 5332
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Kif13a
Name: kinesin family member 13A
Synonyms: N-3 kinesin, 4930505I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99470
Homologene: 26431
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Nle1
Name: notchless homolog 1
Synonyms: notchless, Nle, l11Jus4, l11Jus1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217011
Homologene: 5494
Cox16
Name: cytochrome c oxidase assembly protein 16
Synonyms: 1810055I05Rik, 1810020G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66272
Homologene: 9520
Invs
Name: inversin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16348
Homologene: 7786
Dennd6b
Name: DENN/MADD domain containing 6B
Synonyms: 1700027J05Rik, Fam116b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69440
VEGA: 15
Homologene: 57065
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237954
Homologene: 138824
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69439
Homologene: 72545
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: CaMK II, 2810011D23Rik, 8030469K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Cyb5d1
Name: cytochrome b5 domain containing 1
Synonyms: LOC327951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327951
Homologene: 15945
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67016
Homologene: 56694
Stard7
Name: START domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99138
Homologene: 32463
Shroom1
Name: shroom family member 1
Synonyms: 1300007L22Rik, Shrm1, Apx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71774
Homologene: 12411
Nsun4
Name: NOL1/NOP2/Sun domain family, member 4
Synonyms: 2310010O12Rik, 2810405F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72181
Homologene: 12455
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229595
Homologene: 23141
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11981
Homologene: 69194
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Zfp91
Name: zinc finger protein 91
Synonyms: Pzf, 9130014I08Rik, A530054C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109910
Homologene: 43144
Fbxl2
Name: F-box and leucine-rich repeat protein 2
Synonyms: 2810423A21Rik, Fbl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72179
Homologene: 135814
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11, Olfr935
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Or4z4
Name: olfactory receptor family 4 subfamily Z member 4
Synonyms: GA_x6K02T2RE5P-2458473-2457538, MOR239-4, Olfr1427
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258674
Homologene: 128080
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233799
Homologene: 70404
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Or5b117
Name: olfactory receptor family 5 subfamily B member 117
Synonyms: GA_x6K02T2RE5P-3787124-3786180, MOR202-16, Olfr1472
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258685
Homologene: 77370
Rdh12
Name: retinol dehydrogenase 12
Synonyms: A930033N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77974
Homologene: 110830
Or4b1d
Name: olfactory receptor family 4 subfamily B member 1D
Synonyms: MTPCR05, MOR227-7P, GA_x6K02T2Q125-51573576-51572650, MOR227-9_p, Olfr32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18331
HGNC: HGNC:8290
Homologene: 110550
Snap23
Name: synaptosomal-associated protein 23
Synonyms: Syndet, SNAP-23, Sndt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20619
Homologene: 37857
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Casper, A430105C05Rik, Flip, c-Flip, 2310024N18Rik, Cash
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
Abitram
Name: actin binding transcription modulator
Synonyms: BC026590, simiate, Fam206a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230234
HGNC: HGNC:1364
Homologene: 56788
Podxl
Name: podocalyxin-like
Synonyms: Pclp1, Ly102, PC, podocalyxin, Podxl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27205
HGNC: HGNC:9171
Homologene: 137260
Gm17244
Name: predicted gene, 17244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Gm14149
Name: predicted gene 14149
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100038513
Arhgap27os2
Name: Rho GTPase activating protein 27, opposite strand 2
Synonyms: Gm11647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
4930511M06Rik
Name: RIKEN cDNA 4930511M06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75084
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,752,392 bp
  • T to C, chromosome 1 at 71,619,391 bp
  • T to A, chromosome 2 at 90,138,892 bp
  • C to A, chromosome 2 at 120,594,865 bp
  • C to T, chromosome 2 at 127,292,199 bp
  • T to A, chromosome 2 at 148,709,276 bp
  • C to A, chromosome 2 at 151,230,596 bp
  • T to C, chromosome 2 at 168,639,937 bp
  • A to G, chromosome 3 at 34,650,789 bp
  • A to T, chromosome 3 at 95,681,357 bp
  • A to T, chromosome 3 at 104,015,502 bp
  • T to C, chromosome 3 at 126,840,316 bp
  • T to A, chromosome 3 at 157,973,005 bp
  • G to A, chromosome 4 at 48,396,337 bp
  • G to A, chromosome 4 at 56,803,553 bp
  • C to T, chromosome 4 at 116,051,777 bp
  • G to A, chromosome 4 at 123,114,576 bp
  • T to A, chromosome 5 at 101,861,448 bp
  • A to T, chromosome 5 at 125,387,275 bp
  • G to T, chromosome 5 at 136,275,317 bp
  • A to G, chromosome 6 at 24,603,889 bp
  • A to T, chromosome 6 at 31,526,613 bp
  • G to T, chromosome 6 at 113,253,807 bp
  • A to T, chromosome 6 at 122,084,381 bp
  • T to C, chromosome 7 at 119,573,617 bp
  • T to C, chromosome 7 at 137,445,022 bp
  • G to A, chromosome 8 at 128,425,915 bp
  • T to C, chromosome 9 at 38,994,628 bp
  • C to A, chromosome 9 at 53,570,242 bp
  • T to C, chromosome 9 at 90,218,969 bp
  • A to T, chromosome 9 at 113,985,347 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • A to C, chromosome 10 at 117,690,612 bp
  • T to C, chromosome 11 at 49,827,146 bp
  • A to T, chromosome 11 at 53,463,698 bp
  • C to A, chromosome 11 at 69,393,735 bp
  • T to C, chromosome 11 at 82,903,182 bp
  • G to A, chromosome 11 at 97,669,500 bp
  • C to T, chromosome 11 at 100,514,979 bp
  • A to G, chromosome 11 at 103,360,146 bp
  • T to C, chromosome 11 at 103,500,535 bp
  • A to G, chromosome 11 at 121,602,012 bp
  • T to C, chromosome 12 at 75,921,244 bp
  • T to A, chromosome 12 at 79,210,784 bp
  • T to A, chromosome 12 at 79,246,521 bp
  • T to C, chromosome 12 at 81,472,258 bp
  • T to C, chromosome 13 at 3,884,320 bp
  • T to A, chromosome 13 at 11,745,601 bp
  • G to A, chromosome 13 at 46,752,115 bp
  • A to G, chromosome 15 at 66,827,293 bp
  • T to C, chromosome 15 at 74,606,154 bp
  • G to A, chromosome 15 at 89,185,022 bp
  • T to C, chromosome 15 at 98,839,676 bp
  • T to C, chromosome 16 at 22,040,522 bp
  • T to A, chromosome 17 at 20,278,422 bp
  • G to C, chromosome 17 at 46,324,259 bp
  • C to T, chromosome 17 at 66,689,358 bp
  • G to A, chromosome 18 at 57,538,084 bp
  • T to A, chromosome 19 at 12,098,977 bp
  • T to C, chromosome 19 at 12,779,087 bp
  • A to T, chromosome 19 at 13,453,968 bp
  • A to T, chromosome 19 at 22,987,258 bp
  • T to A, chromosome 19 at 40,915,401 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5509 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043070-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.