Strain Name:
C57BL/6J-MtgxR5518Btlr/Mmmh
Stock Number:
043077-MU
Citation ID:
RRID:MMRRC_043077-MU
Other Names:
R5518 (G1), C57BL/6J-MtgxR5518Btlr
Major Collection:

Gene Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ubxn2a
Name: UBX domain protein 2A
Synonyms: 6330407P03Rik, Ubxd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217379
Homologene: 17076
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Tmem121
Name: transmembrane protein 121
Synonyms: Hole, 2410008J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69195
Homologene: 11900
Abcc8
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Cpne3
Name: copine III
Synonyms: PRO1071, CPN3, 5730450C07Rik, 5430428M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70568
HGNC: HGNC:2316
Homologene: 20839
Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
Synonyms: 1700021B03Rik, 0710001P09Rik, Micos25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66098
Homologene: 11920
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235469
Homologene: 17151
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233545
Homologene: 32465
Smg6
Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103677
Homologene: 23024
Ins1
Name: insulin I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16333
VEGA: 19
Homologene: 7383
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
G3bp2
Name: GTPase activating protein (SH3 domain) binding protein 2
Synonyms: G3BP, G3BP2, E430034L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23881
Homologene: 137244
Smtnl2
Name: smoothelin-like 2
Synonyms: D130058I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276829
Homologene: 82367
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239319
Homologene: 13067
Pld3
Name: phospholipase D family, member 3
Synonyms: Sam-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18807
Homologene: 7893
Abcf1
Name: ATP-binding cassette, sub-family F (GCN20), member 1
Synonyms: Abc50, D17Wsu166e, GCN20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224742
HGNC: HGNC:70
Homologene: 849
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Cbx3
Name: chromobox 3
Synonyms: M32, heterochromatin protein 1 gamma, HP1g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12417
HGNC: HGNC:1553
Homologene: 40583
Tmem201
Name: transmembrane protein 201
Synonyms: D4Ertd429e, Samp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230917
Homologene: 35319
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Mta2
Name: metastasis-associated gene family, member 2
Synonyms: mmta2, Mta1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23942
HGNC: HGNC:7411
Homologene: 3480
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232339
Homologene: 45968
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, diminished cone electroretinogram, dice, Cpfl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70882
Homologene: 31589
Cntn1
Name: contactin 1
Synonyms: CNTN, F3cam, usl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12805
HGNC: HGNC:2171
Homologene: 7274
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277978
Homologene: 18629
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319767
Homologene: 70969
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
C4b
Name: complement component 4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320207
Homologene: 8627
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Vwde
Name: von Willebrand factor D and EGF domains
Synonyms: LOC232585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232585
Homologene: 35456
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Asb10
Name: ankyrin repeat and SOCS box-containing 10
Synonyms: Asb-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117590
Homologene: 135975
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: Neu, Neu oncogene, c-erbB2, HER-2, ErbB-2, HER2, c-neu, l11Jus8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Blk
Name: B lymphoid kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12143
VEGA: 14
HGNC: HGNC:1057
Homologene: 1297
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: BFIT1, 2010309H15Rik, Them1, 1110020M10Rik, Thea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329910
Homologene: 11977
Olfr1423
Name: olfactory receptor 1423
Synonyms: GA_x6K02T2RE5P-2393361-2392429, MOR239-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258675
Homologene: 128078
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71062
Homologene: 12896
Klrb1
Name: killer cell lectin-like receptor subfamily B member 1
Synonyms: Ly-55, Ly55, Gm4696, 4930431A04Rik, Nkrp1g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043861
Homologene: 135763
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Mcat
Name: malonyl CoA:ACP acyltransferase (mitochondrial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223722
VEGA: 15
Homologene: 15511
Mknk2
Name: MAP kinase-interacting serine/threonine kinase 2
Synonyms: Mnk2, 2010016G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17347
HGNC: HGNC:7111
Homologene: 49674
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: E330012B09Rik, Gcap8, Galnt19, Wbscr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212996
Homologene: 49707
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67880
Homologene: 22964
Krtap24-1
Name: keratin associated protein 24-1
Synonyms: LOC239932, Gm312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239932
VEGA: 16
Homologene: 88056
Catsper2
Name: cation channel, sperm associated 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 212670
Homologene: 77423
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233890
Homologene: 11650
Gm6003
Name: predicted gene 6003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102637838
Homologene: 141213
Ighv5-12-4
Name: immunoglobulin heavy variable 5-12-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 628098
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 2 at 19,297,928 bp
  • T to A, chromosome 2 at 31,790,742 bp
  • T to C, chromosome 2 at 121,406,363 bp
  • T to A, chromosome 2 at 162,278,223 bp
  • T to C, chromosome 3 at 125,438,456 bp
  • A to T, chromosome 3 at 126,959,699 bp
  • T to G, chromosome 4 at 19,553,779 bp
  • T to C, chromosome 4 at 55,009,818 bp
  • T to C, chromosome 4 at 64,017,679 bp
  • C to A, chromosome 4 at 106,750,010 bp
  • T to C, chromosome 4 at 149,718,077 bp
  • G to A, chromosome 5 at 24,539,645 bp
  • T to A, chromosome 5 at 92,068,488 bp
  • A to T, chromosome 5 at 111,225,928 bp
  • A to G, chromosome 5 at 130,900,590 bp
  • A to G, chromosome 5 at 143,173,309 bp
  • T to C, chromosome 6 at 13,186,938 bp
  • C to T, chromosome 6 at 48,496,654 bp
  • C to T, chromosome 6 at 51,481,746 bp
  • A to G, chromosome 6 at 89,567,585 bp
  • T to C, chromosome 6 at 118,548,908 bp
  • T to A, chromosome 6 at 128,706,525 bp
  • T to C, chromosome 7 at 27,532,371 bp
  • T to A, chromosome 7 at 33,165,579 bp
  • C to T, chromosome 7 at 46,120,449 bp
  • T to C, chromosome 7 at 98,593,611 bp
  • G to A, chromosome 7 at 105,703,209 bp
  • A to G, chromosome 7 at 127,344,411 bp
  • T to C, chromosome 8 at 105,293,163 bp
  • C to G, chromosome 8 at 122,890,994 bp
  • T to C, chromosome 9 at 42,037,212 bp
  • A to G, chromosome 9 at 72,324,135 bp
  • G to T, chromosome 9 at 88,383,802 bp
  • A to T, chromosome 9 at 106,072,188 bp
  • A to T, chromosome 10 at 80,668,641 bp
  • T to C, chromosome 11 at 43,151,636 bp
  • C to A, chromosome 11 at 63,083,942 bp
  • G to A, chromosome 11 at 68,477,468 bp
  • A to T, chromosome 11 at 72,401,516 bp
  • T to C, chromosome 11 at 75,053,898 bp
  • G to T, chromosome 11 at 98,422,770 bp
  • A to T, chromosome 11 at 103,615,253 bp
  • A to C, chromosome 11 at 120,726,199 bp
  • T to C, chromosome 12 at 4,902,238 bp
  • T to A, chromosome 12 at 75,945,170 bp
  • A to C, chromosome 12 at 103,950,828 bp
  • T to C, chromosome 12 at 113,188,927 bp
  • A to G, chromosome 12 at 113,762,534 bp
  • T to C, chromosome 13 at 11,687,909 bp
  • A to G, chromosome 14 at 56,482,133 bp
  • G to T, chromosome 14 at 63,378,507 bp
  • G to T, chromosome 15 at 5,105,214 bp
  • A to G, chromosome 15 at 83,547,674 bp
  • G to A, chromosome 15 at 92,314,653 bp
  • T to C, chromosome 16 at 15,678,308 bp
  • A to T, chromosome 16 at 88,611,708 bp
  • T to G, chromosome 17 at 27,087,592 bp
  • G to C, chromosome 17 at 34,734,442 bp
  • C to T, chromosome 17 at 35,958,341 bp
  • T to A, chromosome 17 at 75,516,359 bp
  • A to G, chromosome 18 at 36,932,362 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • C to A, chromosome 19 at 8,948,092 bp
  • T to C, chromosome 19 at 12,036,065 bp
  • T to C, chromosome 19 at 52,264,739 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5518 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043077-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.