Strain Name:
C57BL/6J-MtgxR5555Btlr/Mmmh
Stock Number:
043112-MU
Citation ID:
RRID:MMRRC_043112-MU
Other Names:
R5555 (G1), C57BL/6J-MtgxR5555Btlr
Major Collection:

Gene Information

Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74244
Homologene: 4662
Ext1
Name: exostoses (multiple) 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Rcan2
Name: regulator of calcineurin 2
Synonyms: Csp2, ZAKI-4, Dscr1l1, MCIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp89, Hsp86-1, hsp4, Hsp90, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Skap2
Name: src family associated phosphoprotein 2
Synonyms: 2610021A10Rik, RA70, Saps, SKAP-HOM, mSKAP55R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54353
Homologene: 2919
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20527
Homologene: 74302
Gtpbp4
Name: GTP binding protein 4
Synonyms: Crfg, Nog1, 2610028C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69237
VEGA: 13
Homologene: 7100
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Sun2
Name: Sad1 and UNC84 domain containing 2
Synonyms: Unc84b, B230369L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223697
Homologene: 9113
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74051
Homologene: 17682
Stk40
Name: serine/threonine kinase 40
Synonyms: 2310004N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74178
Homologene: 12542
Map1s
Name: microtubule-associated protein 1S
Synonyms: Bpy2ip1, 6430517J16Rik, Mtap1s, Map8, VCY2IP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270058
Homologene: 10047
Nbeal1
Name: neurobeachin like 1
Synonyms: ALS2CR17, 2310076G13Rik, A530083I02Rik, A530050O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269198
Homologene: 16453
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, E030034C22Rik, Dnahc1, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Rab38
Name: RAB38, member RAS oncogene family
Synonyms: 2310011F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72433
HGNC: HGNC:9776
Homologene: 21353
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20465
VEGA: 16
Homologene: 3716
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233231
Homologene: 24986
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238455
Homologene: 18813
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231470
Homologene: 23516
Cadm2
Name: cell adhesion molecule 2
Synonyms: SynCAM2, Igsf4d, A830029E02Rik, Necl3, 2900078E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239857
Homologene: 17705
9330182L06Rik
Name: RIKEN cDNA 9330182L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231014
Homologene: 27396
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73470
Homologene: 23775
Irf5
Name: interferon regulatory factor 5
Synonyms: mirf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 27056
HGNC: HGNC:6120
Homologene: 8088
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229541
Homologene: 28281
Snx33
Name: sorting nexin 33
Synonyms: Sh3px3, E130307J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235406
VEGA: 9
Homologene: 45165
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: NaT, NaN, SNS2, NSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 24046
VEGA: 9
Homologene: 8041
Chrac1
Name: chromatin accessibility complex 1
Synonyms: 2410152E03Rik, YCL1, 2810406L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 93696
Homologene: 41174
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 64929
VEGA: 14
Homologene: 2850
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71007
Homologene: 18998
Ngly1
Name: N-glycanase 1
Synonyms: Png1, 1110002C09Rik, PNGase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 59007
Homologene: 10117
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229688
Homologene: 77638
Skint11
Name: selection and upkeep of intraepithelial T cells 11
Synonyms: A630098G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230623
Homologene: 136292
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Vmn1r54
Name: vomeronasal 1 receptor 54
Synonyms: VN7, V1ra9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113851
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20129
Homologene: 84780
Eif2s3y
Name: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
Synonyms: Eif-2gy, Spy, Tfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 26908
Homologene: 99414
Edf1
Name: endothelial differentiation-related factor 1
Synonyms: hypothetical protein 1-9, 0610008L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 59022
HGNC: HGNC:3164
Homologene: 2809
Ear-ps2
Name: eosinophil-associated, ribonuclease A family, pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 93743
Gm14199
Name: predicted gene 14199
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 105244329
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 60,237,152 bp
  • G to T, chromosome 2 at 25,560,986 bp
  • T to C, chromosome 2 at 152,990,100 bp
  • G to A, chromosome 3 at 90,268,368 bp
  • A to T, chromosome 3 at 93,396,701 bp
  • C to T, chromosome 3 at 106,389,952 bp
  • A to G, chromosome 4 at 114,194,601 bp
  • T to C, chromosome 4 at 118,224,924 bp
  • T to A, chromosome 4 at 126,135,059 bp
  • T to C, chromosome 5 at 5,677,544 bp
  • T to A, chromosome 5 at 9,422,296 bp
  • T to A, chromosome 5 at 96,677,377 bp
  • T to C, chromosome 6 at 29,531,146 bp
  • A to G, chromosome 6 at 51,860,018 bp
  • G to A, chromosome 6 at 90,269,365 bp
  • T to C, chromosome 6 at 114,702,053 bp
  • G to A, chromosome 6 at 122,729,901 bp
  • T to A, chromosome 7 at 48,447,775 bp
  • A to G, chromosome 7 at 88,430,487 bp
  • T to C, chromosome 7 at 134,349,591 bp
  • C to T, chromosome 8 at 70,917,107 bp
  • T to A, chromosome 8 at 117,612,995 bp
  • G to A, chromosome 9 at 56,925,397 bp
  • G to T, chromosome 9 at 119,755,238 bp
  • G to T, chromosome 11 at 91,575,460 bp
  • A to T, chromosome 12 at 110,692,734 bp
  • A to T, chromosome 12 at 119,450,375 bp
  • A to G, chromosome 13 at 8,979,427 bp
  • C to T, chromosome 14 at 16,270,508 bp
  • T to A, chromosome 14 at 31,290,819 bp
  • T to C, chromosome 14 at 35,520,705 bp
  • G to A, chromosome 14 at 44,047,060 bp
  • G to A, chromosome 14 at 103,602,206 bp
  • A to G, chromosome 15 at 53,088,143 bp
  • T to C, chromosome 15 at 73,092,880 bp
  • T to C, chromosome 15 at 79,734,127 bp
  • A to T, chromosome 16 at 66,784,815 bp
  • A to G, chromosome 16 at 94,109,456 bp
  • T to A, chromosome 17 at 44,037,030 bp
  • A to T, chromosome 19 at 6,966,219 bp
  • G to A, chromosome Y at 1,016,235 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043112-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.