Strain Name:
C57BL/6J-MtgxR5556Btlr/Mmmh
Stock Number:
043113-MU
Citation ID:
RRID:MMRRC_043113-MU
Other Names:
R5556 (G1), C57BL/6J-MtgxR5556Btlr
Major Collection:

Gene Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72895
Homologene: 12485
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233765
Homologene: 52172
Cdk11b
Name: cyclin-dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12537
Homologene: 22416
Adck2
Name: aarF domain containing kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57869
Homologene: 49103
Aco2
Name: aconitase 2, mitochondrial
Synonyms: Aco3, Aco-2, D10Wsu183e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11429
HGNC: HGNC:118
Homologene: 856
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Cast
Name: calpastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: Fan, factor associated with N-SMase activation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Ska2
Name: spindle and kinetochore associated complex subunit 2
Synonyms: 1110001A07Rik, Fam33a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66140
Homologene: 11926
Panx1
Name: pannexin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55991
HGNC: HGNC:8599
Homologene: 49416
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Cd164l2
Name: CD164 sialomucin-like 2
Synonyms: 2310047N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69655
Homologene: 19231
Zfp334
Name: zinc finger protein 334
Synonyms: D2Ertd535e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228876
Homologene: 23076
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234076
Homologene: 32376
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: CD135, Flk-2, Flt-3, Flk2, wmfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Zfpl1
Name: zinc finger like protein 1
Synonyms: 1500015B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 81909
Homologene: 4935
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: Arhgap14, D130026O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 259302
Homologene: 56686
Casc1
Name: cancer susceptibility candidate 1
Synonyms: Las1, A230084G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320662
Homologene: 41242
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Klhl42
Name: kelch-like 42
Synonyms: C230080I20Rik, Klhdc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232539
Homologene: 45842
Olfr137
Name: olfactory receptor 137
Synonyms: MOR256-18, GA_x6K02T2PSCP-2749525-2748587
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258481
HGNC: HGNC:8261
Homologene: 128084
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229541
Homologene: 28281
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74477
Homologene: 8874
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22625
Homologene: 19318
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235441
Homologene: 4766
Disp3
Name: dispatched RND transporter family member 3
Synonyms: G630052C06Rik, Ptchd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242748
Homologene: 25712
Cst7
Name: cystatin F (leukocystatin)
Synonyms: cystatin-like metastasis-associated protein, CMAP, Leukocystatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13011
HGNC: HGNC:2479
Homologene: 37832
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Tspan10
Name: tetraspanin 10
Synonyms: Ocsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 208634
Homologene: 49972
Cherp
Name: calcium homeostasis endoplasmic reticulum protein
Synonyms: 5730408I11Rik, SCAF6, DAN16, D8Wsu96e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 27967
Homologene: 4656
Decr1
Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Synonyms: Decr, Nadph, 1200012F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67460
HGNC: HGNC:2753
Homologene: 68178
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66646
Homologene: 12005
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010004G08Rik, 3010027N18Rik, 2010005N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Pcdhb6
Name: protocadherin beta 6
Synonyms: Pcdhb5B, PcdhbF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93877
Homologene: 62177
Fam189a1
Name: family with sequence similarity 189, member A1
Synonyms: 5730507A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70638
Homologene: 77705
Olfr824
Name: olfactory receptor 824
Synonyms: GA_x6K02T2PULF-11797746-11796799, MOR210-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258669
Homologene: 45026
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66938
Homologene: 12057
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228536
Homologene: 8976
Gm4204
Name: predicted gene 4204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100043064
Cndp2
Name: CNDP dipeptidase 2 (metallopeptidase M20 family)
Synonyms: Pep-1, Dip-2, 0610010E05Rik, Cn2, Pep1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 94111
Homologene: 10623
Rbpjl
Name: recombination signal binding protein for immunoglobulin kappa J region-like
Synonyms: RBP-J kappa-like, RBP-L, Rbpsuhl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19668
Homologene: 7512
Gm15931
Name: predicted gene 15931
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Trgc4
Name: T cell receptor gamma, constant 4
Synonyms: Tcrg-C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107576
Ear-ps2
Name: eosinophil-associated, ribonuclease A family, pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93743
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 66,706,466 bp
  • T to C, chromosome 1 at 86,973,404 bp
  • C to A, chromosome 1 at 105,693,167 bp
  • G to A, chromosome 1 at 127,834,547 bp
  • T to C, chromosome 1 at 135,233,195 bp
  • T to C, chromosome 2 at 66,324,797 bp
  • T to A, chromosome 2 at 118,916,270 bp
  • A to T, chromosome 2 at 150,570,568 bp
  • A to G, chromosome 2 at 164,408,062 bp
  • T to C, chromosome 2 at 165,380,584 bp
  • A to G, chromosome 2 at 181,033,980 bp
  • A to G, chromosome 3 at 30,238,100 bp
  • G to A, chromosome 3 at 90,268,368 bp
  • C to T, chromosome 4 at 6,398,621 bp
  • C to T, chromosome 4 at 15,919,244 bp
  • T to C, chromosome 4 at 98,944,735 bp
  • T to C, chromosome 4 at 126,162,236 bp
  • T to A, chromosome 4 at 133,223,705 bp
  • C to T, chromosome 4 at 148,258,157 bp
  • C to T, chromosome 4 at 155,634,147 bp
  • G to A, chromosome 5 at 104,338,212 bp
  • T to A, chromosome 5 at 147,332,997 bp
  • T to G, chromosome 6 at 17,534,176 bp
  • T to C, chromosome 6 at 39,583,935 bp
  • T to A, chromosome 6 at 112,739,078 bp
  • T to A, chromosome 6 at 113,147,502 bp
  • C to A, chromosome 6 at 145,175,280 bp
  • C to A, chromosome 6 at 147,108,112 bp
  • A to T, chromosome 7 at 4,274,204 bp
  • A to G, chromosome 7 at 44,344,315 bp
  • A to G, chromosome 7 at 64,856,209 bp
  • G to A, chromosome 7 at 116,164,149 bp
  • T to A, chromosome 7 at 130,674,606 bp
  • G to A, chromosome 8 at 13,294,870 bp
  • C to G, chromosome 8 at 72,467,980 bp
  • G to A, chromosome 8 at 95,108,459 bp
  • T to C, chromosome 8 at 104,967,442 bp
  • A to G, chromosome 9 at 15,007,633 bp
  • G to A, chromosome 9 at 66,544,021 bp
  • T to C, chromosome 9 at 72,851,704 bp
  • A to G, chromosome 10 at 116,251,149 bp
  • A to T, chromosome 10 at 130,126,859 bp
  • A to T, chromosome 11 at 9,258,546 bp
  • T to A, chromosome 11 at 72,175,200 bp
  • A to G, chromosome 11 at 86,327,838 bp
  • G to T, chromosome 11 at 87,121,993 bp
  • A to T, chromosome 11 at 120,444,715 bp
  • T to G, chromosome 12 at 38,127,364 bp
  • A to T, chromosome 12 at 85,268,493 bp
  • A to T, chromosome 13 at 19,352,307 bp
  • A to G, chromosome 13 at 74,695,889 bp
  • G to A, chromosome 14 at 44,047,060 bp
  • T to C, chromosome 15 at 81,889,319 bp
  • T to A, chromosome 17 at 38,305,073 bp
  • T to C, chromosome 17 at 71,752,425 bp
  • G to T, chromosome 17 at 73,897,764 bp
  • T to A, chromosome 18 at 37,334,389 bp
  • A to G, chromosome 18 at 84,672,124 bp
  • T to A, chromosome 19 at 5,464,199 bp
  • C to T, chromosome 19 at 6,082,442 bp
  • C to A, chromosome 19 at 6,490,091 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5556 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043113-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.