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Strain Name:
C57BL/6J-MtgxR5567Btlr/Mmmh
Stock Number:
043124-MU
Citation ID:
RRID:MMRRC_043124-MU
Other Names:
R5567 (G1), C57BL/6J-MtgxR5567Btlr
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, BTF2, D5Ertd679e, 34kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Nub1
Name: negative regulator of ubiquitin-like proteins 1
Synonyms: BS4, NY-REN-18, 4931404D21Rik, 6330412F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53312
Homologene: 41108
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Rgs4
Name: regulator of G-protein signaling 4
Synonyms: ESTM50, ESTM48
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19736
Homologene: 4100
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 11,153,643 bp
  • T to C, chromosome 1 at 30,977,548 bp
  • C to T, chromosome 1 at 36,103,638 bp
  • C to T, chromosome 1 at 39,370,027 bp
  • C to T, chromosome 1 at 75,475,936 bp
  • C to T, chromosome 1 at 119,483,535 bp
  • A to C, chromosome 1 at 132,357,805 bp
  • T to C, chromosome 1 at 169,744,507 bp
  • C to T, chromosome 1 at 175,743,597 bp
  • A to G, chromosome 2 at 26,225,218 bp
  • A to G, chromosome 2 at 26,390,541 bp
  • A to T, chromosome 2 at 34,866,012 bp
  • A to G, chromosome 2 at 49,730,199 bp
  • G to A, chromosome 2 at 85,759,650 bp
  • A to G, chromosome 2 at 105,378,808 bp
  • G to A, chromosome 2 at 114,148,970 bp
  • T to A, chromosome 2 at 152,612,583 bp
  • T to A, chromosome 2 at 164,501,562 bp
  • T to C, chromosome 3 at 53,845,262 bp
  • A to G, chromosome 3 at 139,419,786 bp
  • C to T, chromosome 3 at 142,611,365 bp
  • T to C, chromosome 4 at 112,715,870 bp
  • G to A, chromosome 4 at 152,038,325 bp
  • T to C, chromosome 4 at 154,002,277 bp
  • T to C, chromosome 4 at 155,841,008 bp
  • A to G, chromosome 5 at 24,708,816 bp
  • A to G, chromosome 5 at 32,364,199 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • A to G, chromosome 5 at 142,895,267 bp
  • T to A, chromosome 6 at 29,444,045 bp
  • T to C, chromosome 6 at 32,157,980 bp
  • C to T, chromosome 6 at 86,955,168 bp
  • T to A, chromosome 6 at 87,765,064 bp
  • T to A, chromosome 6 at 91,498,135 bp
  • T to C, chromosome 6 at 125,133,763 bp
  • C to T, chromosome 6 at 132,711,372 bp
  • T to C, chromosome 7 at 35,307,215 bp
  • T to A, chromosome 7 at 43,971,169 bp
  • T to A, chromosome 7 at 86,921,529 bp
  • C to A, chromosome 7 at 96,896,209 bp
  • T to C, chromosome 7 at 120,201,893 bp
  • A to G, chromosome 7 at 123,001,834 bp
  • G to A, chromosome 7 at 141,355,007 bp
  • A to G, chromosome 8 at 10,322,676 bp
  • A to G, chromosome 8 at 15,102,546 bp
  • A to G, chromosome 8 at 72,837,453 bp
  • T to A, chromosome 8 at 120,588,945 bp
  • T to A, chromosome 9 at 3,456,831 bp
  • A to G, chromosome 9 at 19,808,378 bp
  • A to C, chromosome 9 at 56,886,648 bp
  • C to T, chromosome 9 at 76,208,618 bp
  • T to A, chromosome 9 at 83,862,535 bp
  • A to G, chromosome 9 at 101,101,737 bp
  • A to G, chromosome 9 at 110,377,644 bp
  • T to A, chromosome 9 at 118,558,183 bp
  • G to T, chromosome 10 at 62,966,673 bp
  • T to A, chromosome 10 at 76,535,696 bp
  • A to G, chromosome 10 at 76,588,133 bp
  • T to C, chromosome 10 at 86,760,920 bp
  • T to A, chromosome 10 at 89,808,521 bp
  • G to A, chromosome 10 at 103,170,596 bp
  • A to C, chromosome 11 at 23,488,336 bp
  • T to A, chromosome 11 at 71,181,403 bp
  • C to T, chromosome 11 at 73,425,446 bp
  • A to G, chromosome 11 at 87,727,445 bp
  • G to T, chromosome 11 at 114,784,738 bp
  • C to T, chromosome 11 at 120,384,614 bp
  • A to G, chromosome 12 at 81,732,024 bp
  • T to A, chromosome 12 at 84,368,639 bp
  • T to C, chromosome 13 at 74,040,141 bp
  • T to C, chromosome 13 at 115,089,616 bp
  • A to T, chromosome 14 at 12,473,497 bp
  • C to A, chromosome 14 at 24,192,913 bp
  • A to G, chromosome 14 at 24,296,824 bp
  • A to G, chromosome 14 at 54,282,368 bp
  • C to T, chromosome 14 at 55,075,269 bp
  • A to G, chromosome 15 at 16,855,844 bp
  • A to T, chromosome 15 at 47,645,468 bp
  • A to G, chromosome 15 at 93,254,299 bp
  • G to A, chromosome 15 at 94,527,865 bp
  • A to G, chromosome 15 at 101,846,905 bp
  • A to G, chromosome 16 at 20,283,012 bp
  • A to G, chromosome 16 at 32,777,692 bp
  • G to A, chromosome 16 at 44,492,824 bp
  • T to C, chromosome 17 at 7,363,803 bp
  • C to T, chromosome 17 at 17,712,074 bp
  • T to A, chromosome 17 at 24,896,849 bp
  • C to T, chromosome 17 at 27,103,906 bp
  • A to G, chromosome 17 at 28,359,198 bp
  • A to T, chromosome 17 at 33,089,457 bp
  • A to G, chromosome 17 at 80,297,280 bp
  • G to A, chromosome 18 at 63,019,325 bp
  • T to A, chromosome 19 at 12,832,659 bp
  • T to C, chromosome 19 at 47,857,899 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5567 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043124-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.