Strain Name:
C57BL/6J-MtgxR5573Btlr/Mmmh
Stock Number:
043128-MU
Citation ID:
RRID:MMRRC_043128-MU
Other Names:
R5573 (G1), C57BL/6J-MtgxR5573Btlr
Major Collection:

Strain Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: C330013D05Rik, MTGR1, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170750
Homologene: 6424
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, alpha-fodrin, Spna2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Lcmt1
Name: leucine carboxyl methyltransferase 1
Synonyms: Lcmt, LCMT-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30949
Homologene: 41123
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, Gm15797, D16Ertd95e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Diaph1
Name: diaphanous related formin 1
Synonyms: mDia1, p140mDia, Drf1, Dia1, D18Wsu154e, Diap1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Ddx27
Name: DEAD box helicase 27
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228889
Homologene: 6431
Ptbp3
Name: polypyrimidine tract binding protein 3
Synonyms: Rod1, 5830471K22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230257
Homologene: 55872
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Limk2
Name: LIM domain kinase 2
Synonyms: whe, A930024P04Rik, Limk2a, Limk2b, LIM kinase 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Ube2v2
Name: ubiquitin-conjugating enzyme E2 variant 2
Synonyms: 5730524P06Rik, 4632410D19Rik, 1110021H13Rik, MMS2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70620
Homologene: 55739
Mettl23
Name: methyltransferase like 23
Synonyms: 1110005A03Rik, 4933424L15Rik, 1500035B17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74319
Homologene: 12552
Dhx29
Name: DExH-box helicase 29
Synonyms: DEAH (Asp-Glu-Ala-His) box polypeptide 29, E130202M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Wdr18
Name: WD repeat domain 18
Synonyms: 2310012I10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216156
VEGA: 10
Homologene: 32573
Dse
Name: dermatan sulfate epimerase
Synonyms: B130024B19Rik, Sart2, DS-epi1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212898
VEGA: 10
Homologene: 8354
Cachd1
Name: cache domain containing 1
Synonyms: 1190007F10Rik, Vwcd1, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Tapt1
Name: transmembrane anterior posterior transformation 1
Synonyms: 4932414K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231225
Homologene: 80206
Peg10
Name: paternally expressed 10
Synonyms: Rtl2, MEF3L, MyEF-3, Mar2, MyEF-3 like, Edr, HB-1, Mart2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: D13Bwg1089e, p190RhoGEF, RIP2, Rho specific exchange factor, RhoGEF, 9230110L08Rik, Rgnef
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: CtIP, 9930104E21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Vwa5b1
Name: von Willebrand factor A domain containing 5B1
Synonyms: 4931403E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75718
Homologene: 19431
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Myrfl
Name: myelin regulatory factor-like
Synonyms: LOC237558, Gm239
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Or8b53
Name: olfactory receptor family 8 subfamily B member 53
Synonyms: GA_x6K02T2PVTD-32458442-32459374, MOR165-6, Olfr920
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258783
VEGA: 9
Serpinb9d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9d
Synonyms: ovalbumin, Spi9, AT2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20726
HGNC: HGNC:8955
Homologene: 69093
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381409
Homologene: 18643
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74149
Plekhg6
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Synonyms: LOC213522
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213522
Homologene: 32395
Rbbp8nl
Name: RBBP8 N-terminal like
Synonyms: BC066135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271887
Homologene: 76811
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Asic5
Name: acid-sensing ion channel family member 5
Synonyms: Accn5, brain-liver-intestine amiloride-sensitive sodium channel, BLINaC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58170
Homologene: 41171
Ugt3a1
Name: UDP glycosyltransferases 3 family, polypeptide A1
Synonyms: Ugt3a2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223337
Homologene: 122787
Csn3
Name: casein kappa
Synonyms: Csnk, CSN10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: B230218P12Rik, A330103J02Rik, LOC382816, B330007M19Rik, Chapsyn-110, PSD93, Dlgh2, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Gm11011
Name: predicted gene 11011
Type: Gene
Species: Mouse
Chromosome: 2
Or52r1b
Name: olfactory receptor family 52 subfamily R member 1B
Synonyms: MOR30-3, GA_x6K02T2PBJ9-5752857-5753801, Olfr582
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259055
Homologene: 73943
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 97,127,931 bp
  • A to G, chromosome 2 at 11,501,672 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • C to T, chromosome 2 at 29,986,492 bp
  • A to G, chromosome 2 at 154,436,862 bp
  • G to T, chromosome 2 at 167,017,886 bp
  • A to T, chromosome 2 at 169,587,472 bp
  • T to C, chromosome 2 at 178,466,689 bp
  • G to A, chromosome 2 at 180,279,793 bp
  • C to T, chromosome 2 at 180,619,732 bp
  • T to A, chromosome 3 at 82,004,484 bp
  • T to C, chromosome 3 at 83,049,677 bp
  • A to G, chromosome 4 at 59,485,626 bp
  • A to C, chromosome 4 at 100,974,079 bp
  • T to C, chromosome 4 at 138,608,890 bp
  • G to A, chromosome 5 at 44,218,078 bp
  • A to G, chromosome 5 at 87,930,051 bp
  • A to G, chromosome 6 at 4,755,913 bp
  • T to G, chromosome 6 at 125,375,792 bp
  • T to C, chromosome 7 at 29,015,723 bp
  • A to G, chromosome 7 at 91,997,324 bp
  • A to T, chromosome 7 at 103,042,340 bp
  • T to A, chromosome 7 at 123,401,463 bp
  • T to C, chromosome 9 at 13,793,167 bp
  • T to A, chromosome 9 at 38,755,704 bp
  • T to G, chromosome 9 at 59,871,001 bp
  • C to A, chromosome 10 at 34,152,682 bp
  • C to T, chromosome 10 at 79,965,038 bp
  • A to G, chromosome 10 at 116,822,756 bp
  • A to T, chromosome 11 at 3,350,398 bp
  • G to T, chromosome 11 at 59,034,705 bp
  • A to G, chromosome 11 at 78,025,045 bp
  • A to G, chromosome 11 at 116,843,611 bp
  • C to T, chromosome 12 at 111,997,902 bp
  • A to G, chromosome 13 at 33,196,440 bp
  • A to T, chromosome 13 at 97,929,491 bp
  • G to A, chromosome 13 at 112,933,215 bp
  • T to C, chromosome 15 at 9,361,683 bp
  • A to G, chromosome 16 at 15,556,479 bp
  • A to G, chromosome 16 at 18,916,599 bp
  • T to A, chromosome 17 at 22,454,695 bp
  • T to C, chromosome 17 at 34,581,156 bp
  • A to G, chromosome 18 at 11,722,607 bp
  • A to G, chromosome 18 at 37,896,373 bp
  • A to C, chromosome 19 at 8,071,097 bp
  • A to G, chromosome 19 at 53,004,822 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5573 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043128-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.