Strain Name:
C57BL/6J-MtgxR5598Btlr/Mmmh
Stock Number:
043150-MU
Citation ID:
RRID:MMRRC_043150-MU
Other Names:
R5598 (G1), C57BL/6J-MtgxR5598Btlr
Major Collection:

Gene Information

Ubn2
Name: ubinuclein 2
Synonyms: 6030408G03Rik, 2900060J04Rik, D130059P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320538
Homologene: 45564
Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, D2R, Drd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Lgi1
Name: leucine-rich repeat LGI family, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56839
HGNC: HGNC:6572
Homologene: 3737
Atf2
Name: activating transcription factor 2
Synonyms: mXBP, Creb2, ATF-2, CRE-BP, D130078H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Cradd
Name: CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms: RAIDD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12905
VEGA: 10
HGNC: HGNC:2340
Homologene: 2821
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: PDI-Q2, ERp61, Grp58, PDI, Erp, Plca, ERp60, ERp57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, Tmem16f, 2900059G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Pogz
Name: pogo transposable element with ZNF domain
Synonyms: 9530006B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229584
Homologene: 9022
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: A330064G03Rik, U5-200KD, Ascc3l1, HELIC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Cmss1
Name: cms small ribosomal subunit 1
Synonyms: 2610528E23Rik, 4930572F24Rik, 1110001A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66497
VEGA: 16
Homologene: 11979
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11538
Homologene: 7617
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, Gtl4, cat eye syndrome chromosome region, candidate 2, 2810409N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: NCAM-120, NCAM-1, CD56, E-NCAM, NCAM-180, NCAM-140, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 3200002M13Rik, 1110028I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: Atip1, B430305I03Rik, MTSG1, MD44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102103
Homologene: 100292
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: Aadacl1, CPO-BP, mKIAA1363, B230106I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320024
Homologene: 23251
Kif18b
Name: kinesin family member 18B
Synonyms: 3000004C01Rik, N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70218
Homologene: 15214
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Susd4
Name: sushi domain containing 4
Synonyms: E430021N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96935
Homologene: 23062
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Col1a-2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, Fath2, EMI2, mKIAA0811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, flamingo, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Olfr591
Name: olfactory receptor 591
Synonyms: GA_x6K02T2PBJ9-5889409-5888465, MOR24-1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258139
Homologene: 79429
Chrna1
Name: cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Synonyms: Acra, Achr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11435
HGNC: HGNC:1955
Homologene: 59
Tmco4
Name: transmembrane and coiled-coil domains 4
Synonyms: 4632413C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77056
Homologene: 57112
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Loxl1
Name: lysyl oxidase-like 1
Synonyms: LOXL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16949
VEGA: 9
HGNC: HGNC:6665
Homologene: 4074
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210417
Homologene: 18180
Olfr56
Name: olfactory receptor 56
Synonyms: IF7, GA_x6K02T2QP88-6300500-6299553, MOR276-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18356
HGNC: HGNC:8280
Homologene: 22608
Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Synonyms: 11(beta)-HSD2, 11HSD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15484
HGNC: HGNC:5209
Homologene: 20088
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382014
Homologene: 124473
Myrf
Name: myelin regulatory factor
Synonyms: Gm98, LOC386531, LOC225908
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Gc
Name: vitamin D binding protein
Synonyms: DBP, vitamin D binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14473
HGNC: HGNC:4187
Homologene: 486
Nhlrc4
Name: NHL repeat containing 4
Synonyms: F430201B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 621239
Homologene: 134625
Olfr906
Name: olfactory receptor 906
Synonyms: MOR167-2, GA_x6K02T2PVTD-32194085-32195020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Cish
Name: cytokine inducible SH2-containing protein
Synonyms: cytokine-inducible SH2 protein, CIS1, Cis, F23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12700
HGNC: HGNC:1984
Homologene: 7667
Aqp2
Name: aquaporin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11827
VEGA: 15
HGNC: HGNC:634
Homologene: 20137
Ccr1l1
Name: chemokine (C-C motif) receptor 1-like 1
Synonyms: MIP-1 alphaRL1, Cmkbr1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12770
VEGA: 9
Homologene: 56388
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Gm17224
Name: predicted gene 17224
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102638851
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 129,595,841 bp
  • C to T, chromosome 1 at 172,213,291 bp
  • T to C, chromosome 1 at 182,892,070 bp
  • T to A, chromosome 2 at 73,566,731 bp
  • A to T, chromosome 2 at 73,863,146 bp
  • C to A, chromosome 2 at 121,414,130 bp
  • A to G, chromosome 2 at 127,226,087 bp
  • T to A, chromosome 2 at 152,984,314 bp
  • T to A, chromosome 2 at 161,014,112 bp
  • T to C, chromosome 2 at 168,183,725 bp
  • A to G, chromosome 3 at 27,226,099 bp
  • T to A, chromosome 3 at 94,864,509 bp
  • A to G, chromosome 3 at 108,402,803 bp
  • A to G, chromosome 4 at 139,053,905 bp
  • T to C, chromosome 5 at 89,438,450 bp
  • A to G, chromosome 6 at 4,516,916 bp
  • G to A, chromosome 6 at 38,490,388 bp
  • A to G, chromosome 6 at 120,731,446 bp
  • A to T, chromosome 7 at 103,173,634 bp
  • A to T, chromosome 8 at 41,022,555 bp
  • A to G, chromosome 8 at 71,482,577 bp
  • G to A, chromosome 8 at 105,522,511 bp
  • A to T, chromosome 9 at 38,488,525 bp
  • A to G, chromosome 9 at 49,407,015 bp
  • A to G, chromosome 9 at 49,545,751 bp
  • A to G, chromosome 9 at 58,312,367 bp
  • T to C, chromosome 9 at 107,297,028 bp
  • A to G, chromosome 9 at 123,977,993 bp
  • A to G, chromosome 10 at 74,635,603 bp
  • G to T, chromosome 10 at 95,175,804 bp
  • C to G, chromosome 11 at 49,135,114 bp
  • T to A, chromosome 11 at 55,281,130 bp
  • C to T, chromosome 11 at 69,406,074 bp
  • G to A, chromosome 11 at 72,916,521 bp
  • G to A, chromosome 11 at 102,908,189 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • C to A, chromosome 14 at 33,133,497 bp
  • ACCCCC to ACCCCCCCCCCCC, chromosome 14 at 55,503,999 bp
  • A to G, chromosome 15 at 95,941,347 bp
  • G to T, chromosome 15 at 99,579,112 bp
  • C to T, chromosome 16 at 29,257,077 bp
  • C to A, chromosome 16 at 57,311,286 bp
  • T to C, chromosome 17 at 19,080,899 bp
  • T to C, chromosome 17 at 24,447,129 bp
  • G to A, chromosome 17 at 25,943,492 bp
  • A to G, chromosome 18 at 37,144,423 bp
  • G to A, chromosome 18 at 49,864,478 bp
  • C to T, chromosome 19 at 10,215,290 bp
  • A to G, chromosome 19 at 38,306,181 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5598 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043150-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.