Strain Name:
C57BL/6J-MtgxR5601Btlr/Mmmh
Stock Number:
043153-MU
Citation ID:
RRID:MMRRC_043153-MU
Other Names:
R5601 (G1), C57BL/6J-MtgxR5601Btlr
Major Collection:

Gene Information

Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: fatty acid transport protein 4, FATP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26569
Homologene: 68437
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225913
VEGA: 19
Homologene: 56710
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, Tara, EST478828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110253
Homologene: 5104
Auts2
Name: autism susceptibility candidate 2
Synonyms: D830032G16Rik, A730011F23Rik, 2700063G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319974
Homologene: 22907
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Impact
Name: impact, RWD domain protein
Synonyms: E430016J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16210
VEGA: 18
Homologene: 5490
Tbc1d23
Name: TBC1 domain family, member 23
Synonyms: 4930451A13Rik, D030022P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67581
VEGA: 16
Homologene: 10126
Hccs
Name: holocytochrome c synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15159
HGNC: HGNC:4837
Homologene: 3897
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: TEG-267, 6230405A16Rik, Tex261, Tex267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: Cpsf, 2610024B04Rik, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Prss58
Name: protease, serine 58
Synonyms: BC048599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232717
Homologene: 65285
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329252
Homologene: 49680
P4hb
Name: prolyl 4-hydroxylase, beta polypeptide
Synonyms: ERp59, protein disulfide isomerase, Thbp, Pdia1, PDI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18453
HGNC: HGNC:8548
Homologene: 55495
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99683
Homologene: 55968
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 333669
Homologene: 129891
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Slc3a1
Name: solute carrier family 3, member 1
Synonyms: NTAA, D2H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20532
VEGA: 17
Homologene: 37289
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: AGO, Fbxo30, SEL-10, Fbxw6, 1110001A17Rik, Cdc4, Fbw7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50754
Homologene: 117451
Stkld1
Name: serine/threonine kinase-like domain containing 1
Synonyms: LOC279029, Gm711
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279029
Homologene: 19586
Myf6
Name: myogenic factor 6
Synonyms: MRF4, herculin, bHLHc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17878
VEGA: 10
HGNC: HGNC:7566
Homologene: 1850
Acot12
Name: acyl-CoA thioesterase 12
Synonyms: 1300004O04Rik, 4930449F15Rik, Cach
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74156
Homologene: 12540
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624845
Homologene: 83483
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93880
Homologene: 87124
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
Muc3
Name: mucin 3, intestinal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666339
Homologene: 141159
Fut9
Name: fucosyltransferase 9
Synonyms: mFUT9, mFuc-TIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20851
Homologene: 55718
Olfr881
Name: olfactory receptor 881
Synonyms: GA_x6K02T2PVTD-31676771-31677700, MOR162-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258413
Homologene: 74013
Serpinb12
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
Synonyms: 2300003F07Rik, 4833409F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71869
Homologene: 23631
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Fstl1
Name: follistatin-like 1
Synonyms: TSC-36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14314
HGNC: HGNC:3972
Homologene: 5144
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56709
Homologene: 9749
Olfr733
Name: olfactory receptor 733
Synonyms: GA_x6K02T2PMLR-5992342-5991416, MOR241-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258657
Homologene: 128266
Ces2e
Name: carboxylesterase 2E
Synonyms: 9030624L02Rik, Ces5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234673
HGNC: HGNC:1864
Homologene: 86210
Dram1
Name: DNA-damage regulated autophagy modulator 1
Synonyms: 1200002N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71712
Homologene: 41255
Pramel51
Name: PRAME like 51
Synonyms: Gm10436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039315
VEGA: 12
Homologene: 103830
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 106,953,697 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • T to C, chromosome 1 at 150,435,853 bp
  • T to C, chromosome 2 at 26,952,705 bp
  • A to T, chromosome 2 at 29,805,660 bp
  • A to G, chromosome 3 at 84,976,208 bp
  • A to G, chromosome 3 at 90,476,963 bp
  • CTG to CTGGTG, chromosome 3 at 130,040,834 bp
  • T to C, chromosome 4 at 25,620,299 bp
  • C to T, chromosome 5 at 24,438,774 bp
  • A to G, chromosome 5 at 73,417,940 bp
  • G to T, chromosome 5 at 131,476,823 bp
  • A to G, chromosome 5 at 137,138,015 bp
  • A to T, chromosome 6 at 40,897,849 bp
  • T to C, chromosome 6 at 42,587,528 bp
  • A to G, chromosome 6 at 124,743,228 bp
  • GCCAGCA to G, chromosome 7 at 80,098,350 bp
  • T to C, chromosome 8 at 87,782,009 bp
  • A to T, chromosome 8 at 104,929,494 bp
  • C to G, chromosome 9 at 37,992,714 bp
  • C to T, chromosome 9 at 39,591,267 bp
  • G to A, chromosome 9 at 121,800,572 bp
  • GC to G, chromosome 10 at 59,892,752 bp
  • G to A, chromosome 10 at 75,985,952 bp
  • T to G, chromosome 10 at 79,396,191 bp
  • A to T, chromosome 10 at 84,798,578 bp
  • A to G, chromosome 10 at 88,324,767 bp
  • A to C, chromosome 10 at 107,494,614 bp
  • C to T, chromosome 10 at 107,608,430 bp
  • G to A, chromosome 11 at 100,783,175 bp
  • T to A, chromosome 11 at 120,571,615 bp
  • T to C, chromosome 12 at 88,176,047 bp
  • G to T, chromosome 12 at 101,985,355 bp
  • G to A, chromosome 13 at 91,782,910 bp
  • C to A, chromosome 14 at 50,298,861 bp
  • T to A, chromosome 14 at 55,973,789 bp
  • T to A, chromosome 15 at 78,973,633 bp
  • T to C, chromosome 16 at 37,826,799 bp
  • A to G, chromosome 16 at 44,460,186 bp
  • C to A, chromosome 16 at 57,198,309 bp
  • C to A, chromosome 17 at 27,884,494 bp
  • T to C, chromosome 17 at 85,032,891 bp
  • C to T, chromosome 18 at 12,976,007 bp
  • T to C, chromosome 18 at 37,402,206 bp
  • T to C, chromosome 19 at 10,594,563 bp
  • A to G, chromosome 19 at 37,314,980 bp
  • G to A, chromosome X at 169,313,601 bp
  • T to C, chromosome X at 170,676,392 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5601 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043153-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.