Strain Name:
C57BL/6J-MtgxR5603Btlr/Mmmh
Stock Number:
043155-MU
Citation ID:
RRID:MMRRC_043155-MU
Other Names:
R5603 (G1), C57BL/6J-MtgxR5603Btlr
Major Collection:

Gene Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2610208K16Rik, 2410099E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Exoc6b
Name: exocyst complex component 6B
Synonyms: G430127E12Rik, 4930569O18Rik, Sec15b, Sec15l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 75914
Homologene: 44781
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67039
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, B130044K16Rik, monocytic leukemia, qkf, querkopf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 54169
Homologene: 136480
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320487
VEGA: 12
Homologene: 19635
Bud31
Name: BUD31 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231889
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: Cpsf, 100kDa, 2610024B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Gad1
Name: glutamate decarboxylase 1
Synonyms: GAD67, GAD25, Z49976, EP10, Gad-1, GAD44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14415
HGNC: HGNC:4092
Homologene: 635
Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms: Mdu1, Mgp-2hc, Cd98, 4F2HC, Ly-m10, Ly-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 17254
Homologene: 1795
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66631
Homologene: 64464
Tmem120b
Name: transmembrane protein 120B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330189
Homologene: 62404
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nerg1, mGluR6, nob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Gm5422
Name: predicted pseudogene 5422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 432448
VEGA: 10
Ttc39a
Name: tetratricopeptide repeat domain 39A
Synonyms: 4922503N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230603
Homologene: 17739
Skint2
Name: selection and upkeep of intraepithelial T cells 2
Synonyms: B7S3, OTTMUSG00000008540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329919
Homologene: 136741
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: Nmdar2b, GluN2B, NR2B, NMDAR2B, GluRepsilon2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Klrd1
Name: killer cell lectin-like receptor, subfamily D, member 1
Synonyms: CD94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16643
HGNC: HGNC:6378
Homologene: 1705
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72772
Homologene: 11070
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66898
Homologene: 23123
Chaf1b
Name: chromatin assembly factor 1, subunit B (p60)
Synonyms: CAF-IP60, MPHOSPH7, 2600017H24Rik, CAF-I 60 kDa subunit, CAF1, CAF1A, CAF1P60, CAF-1 subunit B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Ccna1
Name: cyclin A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12427
HGNC: HGNC:1577
Homologene: 31203
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK108, A930019C19Rik, Mlck, nmMlck, telokin, MLCK210, 9530072E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 319734
Homologene: 26544
Gm13083
Name: predicted gene 13083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 279185
Homologene: 133722
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: proline-rich tyrosine kinase 2, Raftk, calcium-dependent tyrosine kinase, E430023O05Rik, cellular adhesion kinase beta, PYK2, related adhesion focal tyrosine kinase, CAKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433809
Homologene: 19234
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67307
Spata18
Name: spermatogenesis associated 18
Synonyms: 1700067I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 73472
Homologene: 17057
Ngly1
Name: N-glycanase 1
Synonyms: Png1, 1110002C09Rik, PNGase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 59007
Homologene: 10117
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Cpa6
Name: carboxypeptidase A6
Synonyms: 9030616D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329093
Homologene: 75130
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56709
Homologene: 9749
Mtmr6
Name: myotubularin related protein 6
Synonyms: 4022440C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Npy6r
Name: neuropeptide Y receptor Y6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18169
VEGA: 18
HGNC: HGNC:7959
Homologene: 134692
Rimkla
Name: ribosomal modification protein rimK-like family member A
Synonyms: Rimk, NAAGS-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 194237
Homologene: 18336
Ugt1a2
Name: UDP glucuronosyltransferase 1 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22236
Homologene: 86211
Bud23
Name: BUD23, rRNA methyltransferase and ribosome maturation factor
Synonyms: 1110003N24Rik, Wbscr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66138
Homologene: 5486
Cct8l1
Name: chaperonin containing TCP1, subunit 8 (theta)-like 1
Synonyms: Gm443, LOC242891
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242891
Homologene: 40943
Gm17108
Name: predicted gene 17108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Gm5885
Name: predicted gene 5885
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 545884
Homologene: 79760
Ighv1-42
Name: immunoglobulin heavy variable V1-42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 629906
Ighv1-1
Name: immunoglobulin heavy variable V1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 780834
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,595,562 bp
  • T to C, chromosome 1 at 88,201,426 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • T to C, chromosome 2 at 60,620,362 bp
  • C to A, chromosome 2 at 70,589,829 bp
  • A to G, chromosome 3 at 55,050,909 bp
  • T to C, chromosome 4 at 109,422,566 bp
  • T to A, chromosome 4 at 112,649,764 bp
  • C to T, chromosome 4 at 119,492,385 bp
  • T to A, chromosome 4 at 143,617,496 bp
  • A to T, chromosome 4 at 149,658,855 bp
  • T to C, chromosome 4 at 152,312,394 bp
  • C to T, chromosome 5 at 23,817,058 bp
  • A to G, chromosome 5 at 25,516,499 bp
  • G to A, chromosome 5 at 73,671,232 bp
  • T to A, chromosome 5 at 123,101,642 bp
  • A to G, chromosome 5 at 135,053,361 bp
  • A to G, chromosome 5 at 144,265,977 bp
  • T to C, chromosome 5 at 145,144,959 bp
  • T to C, chromosome 6 at 84,835,144 bp
  • T to A, chromosome 6 at 119,244,285 bp
  • T to A, chromosome 6 at 129,596,780 bp
  • T to C, chromosome 6 at 133,531,355 bp
  • T to C, chromosome 6 at 135,923,397 bp
  • T to A, chromosome 10 at 31,250,844 bp
  • GC to G, chromosome 10 at 59,892,752 bp
  • A to G, chromosome 10 at 63,071,449 bp
  • A to T, chromosome 10 at 76,596,769 bp
  • A to T, chromosome 10 at 127,665,121 bp
  • T to A, chromosome 11 at 50,856,959 bp
  • C to T, chromosome 11 at 94,439,752 bp
  • T to C, chromosome 11 at 97,673,505 bp
  • A to G, chromosome 12 at 51,877,575 bp
  • C to T, chromosome 12 at 83,664,216 bp
  • C to A, chromosome 12 at 101,998,631 bp
  • G to T, chromosome 12 at 114,351,712 bp
  • C to T, chromosome 12 at 114,937,512 bp
  • T to C, chromosome 13 at 65,073,606 bp
  • T to C, chromosome 13 at 69,612,987 bp
  • C to A, chromosome 14 at 16,260,762 bp
  • A to G, chromosome 14 at 21,625,678 bp
  • A to T, chromosome 14 at 60,285,001 bp
  • A to T, chromosome 14 at 66,172,065 bp
  • T to G, chromosome 15 at 28,419,932 bp
  • A to G, chromosome 16 at 34,956,492 bp
  • A to G, chromosome 16 at 93,892,795 bp
  • T to A, chromosome 18 at 44,276,585 bp
  • A to G, chromosome 19 at 8,713,728 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5603 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043155-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.