Strain Name:
C57BL/6J-MtgxR5679Btlr/Mmmh
Stock Number:
043176-MU
Citation ID:
RRID:MMRRC_043176-MU
Other Names:
R5679 (G1), C57BL/6J-MtgxR5679Btlr
Major Collection:

Gene Information

Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Synonyms: MTS1, p19ARF, p16INK4a, INK4a-ARF, p16, ARF-INK4a, Arf, Pctr1, p19ARF, Ink4a/Arf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12578
HGNC: HGNC:1787
Homologene: 55430
Cd9
Name: CD9 antigen
Synonyms: Tspan29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12527
HGNC: HGNC:1709
Homologene: 20420
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Rcl1
Name: RNA terminal phosphate cyclase-like 1
Synonyms: Rnac, 2310040A02Rik, RPCL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 59028
VEGA: 19
Homologene: 4217
Tfcp2l1
Name: transcription factor CP2-like 1
Synonyms: LBP-9, Crtr-1, 4932442M07Rik, D930018N21Rik, 1810030F05Rik, Cp2l1, Tcfcp2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 81879
Homologene: 8730
Dph6
Name: diphthamine biosynthesis 6
Synonyms: 5730421E18Rik, Diphthine ammonia ligase, Atpbd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66632
Homologene: 80244
Ipo13
Name: importin 13
Synonyms: Kap13, Imp13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230673
Homologene: 40968
Lctl
Name: lactase-like
Synonyms: KLPH, E130104I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235435
Homologene: 70710
Fam3d
Name: FAM3 metabolism regulating signaling molecule D
Synonyms: EF-7, 2310076N21Rik, Oit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18300
VEGA: 14
Homologene: 16354
Zfp148
Name: zinc finger protein 148
Synonyms: beta enolase repressor factor 1, BERF-1, BFCOL1, 2210405J08Rik, ZBP-89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140476
Homologene: 15401
Xylt1
Name: xylosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233781
Homologene: 32534
Lox
Name: lysyl oxidase
Synonyms: ras recision gene (rrg), TSC-160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16948
VEGA: 18
HGNC: HGNC:6664
Homologene: 1741
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73707
Homologene: 44544
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: SEL-10, AGO, Fbxo30, Fbxw6, 1110001A17Rik, Cdc4, Fbw7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50754
Homologene: 117451
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319800
Homologene: 77136
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
E230025N22Rik
Name: Riken cDNA E230025N22 gene
Synonyms: EG240216
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240216
Homologene: 131194
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70381
Homologene: 9120
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Nfil3
Name: nuclear factor, interleukin 3, regulated
Synonyms: E4BP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18030
HGNC: HGNC:7787
Homologene: 3928
Olfr513
Name: olfactory receptor 513
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258718
Homologene: 64908
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384219
Homologene: 129606
Chst8
Name: carbohydrate sulfotransferase 8
Synonyms: 1500011J21Rik, GalNAc4ST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68947
Homologene: 41483
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Aldh3a1
Name: aldehyde dehydrogenase family 3, subfamily A1
Synonyms: Ahd-4, Ahd4, Aldh3, Aldh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11670
HGNC: HGNC:405
Homologene: 20175
Dimt1
Name: DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
Synonyms: 1500031M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66254
VEGA: 13
Homologene: 7047
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: 4930500O09Rik, Fam154a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75811
Homologene: 27548
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: 0610006G17Rik, CGI-33, Hirip5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56748
Homologene: 6369
Olfr1120
Name: olfactory receptor 1120
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259031
Homologene: 72054
Olfr1009
Name: olfactory receptor 1009
Synonyms: GA_x6K02T2Q125-47195323-47196267, MOR175-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258565
Homologene: 17297
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Scrt1
Name: scratch family zinc finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170729
VEGA: 15
Homologene: 113534
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 118,668,647 bp
  • A to T, chromosome 2 at 85,722,046 bp
  • T to C, chromosome 2 at 87,357,545 bp
  • T to C, chromosome 2 at 114,567,941 bp
  • A to G, chromosome 2 at 121,368,100 bp
  • T to A, chromosome 3 at 84,977,487 bp
  • G to C, chromosome 3 at 135,603,736 bp
  • C to T, chromosome 4 at 86,445,035 bp
  • T to C, chromosome 4 at 89,276,861 bp
  • A to T, chromosome 4 at 117,894,832 bp
  • T to C, chromosome 5 at 109,054,842 bp
  • T to A, chromosome 5 at 144,207,423 bp
  • T to C, chromosome 6 at 87,019,397 bp
  • A to T, chromosome 6 at 125,462,183 bp
  • A to T, chromosome 6 at 145,007,748 bp
  • G to A, chromosome 7 at 12,810,031 bp
  • T to A, chromosome 7 at 34,675,304 bp
  • A to G, chromosome 7 at 108,754,996 bp
  • A to G, chromosome 7 at 117,643,650 bp
  • T to A, chromosome 7 at 128,134,990 bp
  • T to C, chromosome 8 at 61,684,945 bp
  • T to A, chromosome 9 at 14,786,919 bp
  • T to C, chromosome 9 at 64,122,168 bp
  • G to A, chromosome 11 at 61,217,168 bp
  • T to C, chromosome 11 at 75,452,923 bp
  • A to G, chromosome 11 at 97,336,745 bp
  • A to G, chromosome 13 at 52,968,491 bp
  • A to G, chromosome 13 at 106,947,600 bp
  • T to C, chromosome 14 at 8,349,305 bp
  • T to A, chromosome 15 at 76,519,062 bp
  • T to C, chromosome 15 at 98,854,272 bp
  • T to G, chromosome 16 at 33,495,786 bp
  • T to G, chromosome 18 at 22,067,429 bp
  • C to T, chromosome 18 at 36,685,382 bp
  • T to A, chromosome 18 at 37,092,477 bp
  • T to C, chromosome 18 at 52,528,917 bp
  • G to T, chromosome 19 at 8,335,771 bp
  • A to G, chromosome 19 at 29,121,258 bp
  • T to A, chromosome 19 at 55,231,079 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5679 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043176-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.