Strain Name:
C57BL/6J-MtgxR5702Btlr/Mmmh
Stock Number:
043182-MU
Citation ID:
RRID:MMRRC_043182-MU
Other Names:
R5702 (G1), C57BL/6J-MtgxR5702Btlr
Major Collection:

Gene Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15184
Homologene: 3995
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22771
Homologene: 2562
Scarb2
Name: scavenger receptor class B, member 2
Synonyms: LIMP II, LGP85, Cd36l2, LIMP-2, 9330185J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12492
HGNC: HGNC:1665
Homologene: 48353
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20846
Homologene: 21428
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21848
Homologene: 20830
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75788
Homologene: 10712
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Brap
Name: BRCA1 associated protein
Synonyms: 3010002G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72399
HGNC: HGNC:1099
Homologene: 4926
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 93736
Homologene: 8683
Adat1
Name: adenosine deaminase, tRNA-specific 1
Synonyms: mADAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 30947
HGNC: HGNC:228
Homologene: 8096
Eef1aknmt
Name: EEF1A lysine and N-terminal methyltransferase
Synonyms: 5630401D24Rik, Mettl13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71449
Homologene: 32285
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: DD1, AF529169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329260
Homologene: 11739
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Gm2381
Name: predicted gene 2381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039706
Sgk3
Name: serum/glucocorticoid regulated kinase 3
Synonyms: fy, cytokine-independent survival kinase, Cisk, 2510015P22Rik, A330005P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170755
Homologene: 56582
Zfp346
Name: zinc finger protein 346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26919
Homologene: 8073
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276919
Homologene: 69193
Trmt2a
Name: TRM2 tRNA methyltransferase 2A
Synonyms: Htf9c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15547
Homologene: 7374
Zfp830
Name: zinc finger protein 830
Synonyms: 2410003C20Rik, Omcg1, Ccdc16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66983
Homologene: 41655
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20250
VEGA: 19
Homologene: 136612
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208982
Homologene: 27863
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b1203Clo, b2b1279Clo, b2b598Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ctu2
Name: cytosolic thiouridylase subunit 2
Synonyms: 2310061F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66965
Homologene: 79815
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Fmnl1
Name: formin-like 1
Synonyms: 8030453N10Rik, formin-related gene in leukocytes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Atf6b
Name: activating transcription factor 6 beta
Synonyms: Creb-rp, ATF6beta, Crebl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Spire2
Name: spire type actin nucleation factor 2
Synonyms: Spir-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234857
Homologene: 72212
Olfr350
Name: olfactory receptor 350
Synonyms: GA_x6K02T2NLDC-33544602-33545540, MOR136-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258620
HGNC: HGNC:8211
Homologene: 64897
Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms: XPB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13872
HGNC: HGNC:3435
Homologene: 96
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232664
Homologene: 23378
Ptpn7
Name: protein tyrosine phosphatase, non-receptor type 7
Synonyms: LC-PTP, BPTP-4, C920001D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320139
HGNC: HGNC:9659
Homologene: 15411
Plk5
Name: polo like kinase 5
Synonyms: 6330514A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216166
Homologene: 28072
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78459
Homologene: 134508
4930510E17Rik
Name: RIKEN cDNA 4930510E17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
C1qbp
Name: complement component 1, q subcomponent binding protein
Synonyms: P32, HABP1, D11Wsu182e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12261
HGNC: HGNC:1243
Homologene: 31023
Smim8
Name: small integral membrane protein 8
Synonyms: 2810406B13Rik, 1810030N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66291
Homologene: 10708
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 9,885,720 bp
  • T to C, chromosome 1 at 52,150,221 bp
  • A to G, chromosome 1 at 135,133,844 bp
  • T to C, chromosome 1 at 139,133,675 bp
  • A to G, chromosome 1 at 162,545,980 bp
  • G to A, chromosome 1 at 164,194,547 bp
  • A to G, chromosome 2 at 36,850,934 bp
  • TTTAATGAAGAGCT to TT, chromosome 4 at 34,771,261 bp
  • G to A, chromosome 5 at 8,737,752 bp
  • C to T, chromosome 5 at 92,451,396 bp
  • T to A, chromosome 5 at 121,665,143 bp
  • T to C, chromosome 5 at 144,901,211 bp
  • C to A, chromosome 6 at 29,412,982 bp
  • G to C, chromosome 6 at 37,919,526 bp
  • T to A, chromosome 7 at 42,822,396 bp
  • A to T, chromosome 7 at 80,458,927 bp
  • G to T, chromosome 8 at 111,978,072 bp
  • G to A, chromosome 8 at 122,479,625 bp
  • C to T, chromosome 8 at 123,346,663 bp
  • G to T, chromosome 9 at 53,264,679 bp
  • G to A, chromosome 9 at 62,426,577 bp
  • A to G, chromosome 9 at 76,084,390 bp
  • G to A, chromosome 9 at 89,591,155 bp
  • A to G, chromosome 9 at 91,364,080 bp
  • G to A, chromosome 9 at 92,343,688 bp
  • A to C, chromosome 9 at 114,629,010 bp
  • G to A, chromosome 10 at 80,360,567 bp
  • C to T, chromosome 11 at 53,372,331 bp
  • T to C, chromosome 11 at 58,114,047 bp
  • A to T, chromosome 11 at 69,361,435 bp
  • G to A, chromosome 11 at 70,978,744 bp
  • G to A, chromosome 11 at 76,210,837 bp
  • T to A, chromosome 11 at 82,764,974 bp
  • C to T, chromosome 11 at 102,205,253 bp
  • T to C, chromosome 11 at 103,185,665 bp
  • T to C, chromosome 11 at 106,544,395 bp
  • G to A, chromosome 12 at 40,737,491 bp
  • C to A, chromosome 12 at 118,113,907 bp
  • T to C, chromosome 13 at 55,113,097 bp
  • C to T, chromosome 14 at 65,577,982 bp
  • T to A, chromosome 16 at 13,813,266 bp
  • C to T, chromosome 16 at 18,251,127 bp
  • T to C, chromosome 17 at 20,554,145 bp
  • T to C, chromosome 17 at 34,651,004 bp
  • T to C, chromosome 18 at 20,336,865 bp
  • G to A, chromosome 18 at 32,254,153 bp
  • G to T, chromosome 19 at 5,747,821 bp
  • G to T, chromosome 19 at 9,001,840 bp
  • G to A, chromosome 19 at 44,298,063 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5702 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043182-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.