Strain Name:
C57BL/6J-MtgxR5703Btlr/Mmmh
Stock Number:
043183-MU
Citation ID:
RRID:MMRRC_043183-MU
Other Names:
R5703 (G1), C57BL/6J-MtgxR5703Btlr
Major Collection:

Gene Information

Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dsp, Dpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Ntsr1
Name: neurotensin receptor 1
Synonyms: NTR-1, NTR1, Ntsr1, NT-1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66860
Homologene: 18946
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: 4.1G, D10Ertd398e, Epb4.1l2, NBL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, Pard3a, D8Ertd580e, PAR-3, Par3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93742
Homologene: 10489
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Synonyms: C130027E04Rik, wyatt, MyD88-adapter-like, Mal, Mal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 117149
Homologene: 14285
Git1
Name: GIT ArfGAP 1
Synonyms: Cat-1, p95Cat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216963
HGNC: HGNC:4272
Homologene: 32204
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Odz2, D3Bwg1534e, 2610040L17Rik, 9330187F13Rik, Ten-m2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: Zak, MLTKbeta, B230120H23Rik, MLTKalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Cdc42bpg
Name: CDC42 binding protein kinase gamma (DMPK-like)
Synonyms: MRCKgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240505
Homologene: 28384
Wars
Name: tryptophanyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22375
Homologene: 3084
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Rfng
Name: RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: radical fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19719
HGNC: HGNC:9974
Homologene: 56433
Chst2
Name: carbohydrate sulfotransferase 2
Synonyms: N-acetylglucosamine-6-O-sulfotransferase, GST-2, C130041E03Rik, Gn6st
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54371
HGNC: HGNC:1970
Homologene: 3150
Slc5a2
Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms: Sglt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246787
Homologene: 2289
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, Heatr8, LOC381538
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240411
Ndrg2
Name: N-myc downstream regulated gene 2
Synonyms: Ndr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 29811
VEGA: 14
Homologene: 22785
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140476
Homologene: 15401
Gbp6
Name: guanylate binding protein 6
Synonyms: Mpa2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100702
Homologene: 128731
Fam126a
Name: family with sequence similarity 126, member A
Synonyms: hyccin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 84652
Homologene: 57175
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268297
Homologene: 18262
Hoxa2
Name: homeobox A2
Synonyms: Hox-1.11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15399
HGNC: HGNC:5103
Homologene: 4901
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: A530052M23Rik, 2700007F12Rik, [a]1 (XVI) collagen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Olfr495
Name: olfactory receptor 495
Synonyms: GA_x6K02T2PBJ9-10725148-10726140, MOR204-37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258361
Homologene: 133600
Nr1d2
Name: nuclear receptor subfamily 1, group D, member 2
Synonyms: Rev-erb beta, RVR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 353187
HGNC: HGNC:7963
Homologene: 3763
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4833425H18Rik, 4631426G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78751
Homologene: 35328
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: Pcn, Cyp3a, IIIAm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, Gpr71, T1r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 83770
Homologene: 75323
Olfr1023
Name: olfactory receptor 1023
Synonyms: GA_x6K02T2Q125-47363965-47364900, MOR196-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258580
Homologene: 128087
Pcdhb6
Name: protocadherin beta 6
Synonyms: Pcdhb5B, PcdhbF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93877
Homologene: 62177
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: 4732493F09Rik, 1700003B17Rik, p130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226407
Homologene: 45617
Btd
Name: biotinidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26363
HGNC: HGNC:1122
Homologene: 37255
Krt33b
Name: keratin 33B
Synonyms: Krt1-3, mHa3, Ha4, Ha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16671
Homologene: 74433
Gm13199
Name: predicted gene 13199
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 791411
Gramd2
Name: GRAM domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546134
Homologene: 52791
Faddos
Name: Fas (TNFRSF6)-associated via death domain, opposite strand
Synonyms: Gm10574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 127,901,651 bp
  • C to T, chromosome 2 at 5,862,448 bp
  • T to C, chromosome 2 at 59,795,997 bp
  • A to G, chromosome 2 at 72,402,170 bp
  • T to C, chromosome 2 at 85,887,439 bp
  • T to C, chromosome 2 at 121,370,814 bp
  • A to G, chromosome 2 at 128,993,452 bp
  • T to C, chromosome 2 at 180,500,433 bp
  • A to T, chromosome 4 at 58,877,171 bp
  • A to G, chromosome 4 at 106,708,560 bp
  • G to A, chromosome 4 at 130,053,299 bp
  • T to C, chromosome 4 at 139,667,336 bp
  • A to T, chromosome 5 at 23,980,579 bp
  • C to T, chromosome 5 at 104,177,051 bp
  • T to C, chromosome 5 at 105,273,281 bp
  • A to T, chromosome 5 at 145,860,373 bp
  • G to T, chromosome 6 at 52,163,263 bp
  • C to T, chromosome 7 at 12,629,667 bp
  • G to A, chromosome 7 at 108,395,500 bp
  • A to G, chromosome 7 at 128,270,615 bp
  • A to G, chromosome 7 at 144,580,941 bp
  • A to T, chromosome 8 at 127,371,562 bp
  • A to T, chromosome 9 at 35,188,758 bp
  • G to A, chromosome 9 at 59,708,016 bp
  • A to G, chromosome 9 at 95,404,932 bp
  • C to T, chromosome 10 at 25,441,767 bp
  • C to T, chromosome 10 at 42,865,570 bp
  • T to A, chromosome 11 at 36,023,799 bp
  • CCG to C, chromosome 11 at 77,504,668 bp
  • T to C, chromosome 11 at 97,676,170 bp
  • T to C, chromosome 11 at 100,025,548 bp
  • C to A, chromosome 11 at 120,782,016 bp
  • A to T, chromosome 12 at 108,875,121 bp
  • A to T, chromosome 14 at 18,215,255 bp
  • C to T, chromosome 14 at 31,667,047 bp
  • T to A, chromosome 14 at 51,910,122 bp
  • G to A, chromosome 16 at 32,736,241 bp
  • A to T, chromosome 18 at 37,334,700 bp
  • A to G, chromosome 18 at 77,356,877 bp
  • A to G, chromosome 19 at 6,322,673 bp
  • A to T, chromosome 19 at 12,482,210 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5703 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043183-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.