Strain Name:
C57BL/6J-MtgxR5730Btlr/Mmmh
Stock Number:
043191-MU
Citation ID:
RRID:MMRRC_043191-MU
Other Names:
R5730 (G1), C57BL/6J-MtgxR5730Btlr
Major Collection:

Gene Information

Cd80
Name: CD80 antigen
Synonyms: Ly53, B7.1, Ly-53, Cd28l, B7-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12519
VEGA: 16
HGNC: HGNC:1700
Homologene: 3804
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, BPAG1, A830042E19Rik, nmf203, Bpag, Bpag1, 2310001O04Rik, ah, nmf339, BPAG1-n, Macf2, athetoid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Mrpl39
Name: mitochondrial ribosomal protein L39
Synonyms: Rpml5, MRP-L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27393
Homologene: 9679
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Hspy, Fr1, Fgfr-1, FGFR-I, Eask
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Lyz2
Name: lysozyme 2
Synonyms: Lyzs, Lzp, Lzm-s1, Lys, Lzm, Lysm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17105
VEGA: 10
HGNC: HGNC:6740
Homologene: 121490
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66185
Homologene: 41043
Diaph1
Name: diaphanous related formin 1
Synonyms: D18Wsu154e, mDia1, p140mDia, Drf1, Diap1, Dia1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: 6230400I06Rik, Apaf1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Ppp2r5a
Name: protein phosphatase 2, regulatory subunit B', alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226849
HGNC: HGNC:9309
Homologene: 55961
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, Prl14l, C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215476
Homologene: 65866
Klk11
Name: kallikrein related-peptidase 11
Synonyms: Prss20, 2310015I08Rik, TLSP, hippostasin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56538
HGNC: HGNC:6359
Homologene: 27048
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: SII-K1, S-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21401
Homologene: 20684
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59035
Homologene: 10990
Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Synonyms: NMDMC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17768
HGNC: HGNC:7434
Homologene: 21321
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, CD91, A2mr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Trak2
Name: trafficking protein, kinesin binding 2
Synonyms: 2900022D04Rik, OIP98, CALS-C, GRIF1, GRIF-1, Als2cr3, 4733401O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70827
Homologene: 22861
Tnr
Name: tenascin R
Synonyms: TN-R, J1-tenascin, janusin, restrictin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: A230052E19Rik, Nav1.2, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Synpo2
Name: synaptopodin 2
Synonyms: 1110069I04Rik, 9530006G20Rik, Myo, myopodin, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
Tubb1
Name: tubulin, beta 1 class VI
Synonyms: 2810484G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545486
Homologene: 69474
Vmn1r64
Name: vomeronasal 1 receptor 64
Synonyms: V1rd11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404285
Homologene: 41799
Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Synonyms: steroid 17-alpha hydroxylase, p450c17, Cyp17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13074
HGNC: HGNC:2593
Homologene: 73875
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102193
Homologene: 41193
Olfr1240
Name: olfactory receptor 1240
Synonyms: MOR231-8, GA_x6K02T2Q125-50883183-50882239
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258804
Homologene: 121591
Olfr450
Name: olfactory receptor 450
Synonyms: GA_x6K02T2P3E9-4742413-4741481, MOR257-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258437
Homologene: 51720
Gm1553
Name: predicted gene 1553
Synonyms: Lcrn, LOC380643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432480
VEGA: 10
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244199
Homologene: 18255
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: 4831426I19Rik, nesprin-3beta, nesprin-3, nesprin-3alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Gpbar1
Name: G protein-coupled bile acid receptor 1
Synonyms: M-BAR, TGR5, GPR131, BG37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227289
Homologene: 18125
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 4833417L20Rik, 5830409B12Rik, Rsnl2, 1700024K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Vmn1r120
Name: vomeronasal 1 receptor 120
Synonyms: Gm5730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435953
Homologene: 104166
Prss48
Name: protease, serine 48
Synonyms: Esspl, Gm1019
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 368202
Homologene: 133731
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: Gm21505, PSD93, Chapsyn-110, Dlgh2, LOC382816, B230218P12Rik, A330103J02Rik, B330007M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Pstk
Name: phosphoseryl-tRNA kinase
Synonyms: 5430423O14Rik, LOC381976, 5730458D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214580
Homologene: 45167
Gramd2
Name: GRAM domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546134
Homologene: 52791
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 34,117,526 bp
  • T to C, chromosome 1 at 58,921,807 bp
  • A to G, chromosome 1 at 74,279,036 bp
  • A to G, chromosome 1 at 159,888,322 bp
  • C to T, chromosome 1 at 191,372,535 bp
  • T to G, chromosome 2 at 65,495,260 bp
  • C to A, chromosome 2 at 65,682,538 bp
  • T to C, chromosome 2 at 89,439,436 bp
  • T to C, chromosome 2 at 91,158,109 bp
  • A to G, chromosome 2 at 174,457,769 bp
  • T to G, chromosome 3 at 85,997,256 bp
  • T to C, chromosome 3 at 123,114,119 bp
  • T to A, chromosome 4 at 11,542,154 bp
  • T to C, chromosome 4 at 136,264,893 bp
  • T to C, chromosome 5 at 32,793,603 bp
  • T to A, chromosome 5 at 150,569,005 bp
  • A to T, chromosome 6 at 11,953,320 bp
  • C to T, chromosome 6 at 42,818,160 bp
  • C to T, chromosome 6 at 83,317,459 bp
  • G to A, chromosome 7 at 5,884,523 bp
  • A to T, chromosome 7 at 21,053,009 bp
  • G to A, chromosome 7 at 43,774,775 bp
  • G to T, chromosome 7 at 92,386,918 bp
  • A to G, chromosome 7 at 107,793,399 bp
  • A to T, chromosome 7 at 131,373,774 bp
  • G to A, chromosome 8 at 16,185,192 bp
  • A to G, chromosome 8 at 25,573,811 bp
  • T to C, chromosome 8 at 120,087,772 bp
  • G to A, chromosome 9 at 21,580,340 bp
  • A to G, chromosome 9 at 59,711,206 bp
  • T to C, chromosome 9 at 108,972,242 bp
  • A to G, chromosome 10 at 82,488,111 bp
  • A to T, chromosome 10 at 91,020,771 bp
  • G to T, chromosome 10 at 117,278,682 bp
  • A to G, chromosome 10 at 127,583,834 bp
  • T to C, chromosome 12 at 104,961,454 bp
  • A to G, chromosome 14 at 115,788,314 bp
  • T to G, chromosome 15 at 88,717,045 bp
  • T to C, chromosome 16 at 38,482,735 bp
  • C to T, chromosome 16 at 84,732,434 bp
  • T to C, chromosome 17 at 25,247,524 bp
  • A to G, chromosome 17 at 71,810,959 bp
  • A to G, chromosome 18 at 37,903,776 bp
  • T to C, chromosome 19 at 9,010,253 bp
  • A to G, chromosome 19 at 46,672,656 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043191-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.