Strain Name:
C57BL/6J-MtgxR5733Btlr/Mmmh
Stock Number:
043193-MU
Citation ID:
RRID:MMRRC_043193-MU
Other Names:
R5733 (G1), C57BL/6J-MtgxR5733Btlr
Major Collection:

Gene Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: D530039E11Rik, 6030405M08Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Cdh1, Fyr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56371
Homologene: 9444
Rorb
Name: RAR-related orphan receptor beta
Synonyms: Nr1f2, RZR-beta, hstp, Rorbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225998
Homologene: 38250
Odf2
Name: outer dense fiber of sperm tails 2
Synonyms: MMTEST29, cenexin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18286
HGNC: HGNC:8114
Homologene: 1907
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Rassf1
Name: Ras association (RalGDS/AF-6) domain family member 1
Synonyms: RDA32, NORE2A, Rassf1A, 123F protein, Rassf1B, Rassf1C, REH3P21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56289
HGNC: HGNC:9882
Homologene: 10499
Dmxl2
Name: Dmx-like 2
Synonyms: 6430411K14Rik, E130119P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Lyzl1
Name: lysozyme-like 1
Synonyms: 1700038F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67328
Homologene: 81913
Pum3
Name: pumilio RNA-binding family member 3
Synonyms: 1110069H02Rik, D19Bwg1357e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52874
VEGA: 19
Homologene: 5762
Knop1
Name: lysine rich nucleolar protein 1
Synonyms: Tsg118, 2310008H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66356
Homologene: 49729
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: Mbs85, 2410197A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232807
Homologene: 75071
Vasn
Name: vasorin
Synonyms: Slitl2, 2610528G05Rik, ATIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246154
Homologene: 36929
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233103
Homologene: 8795
Zfp251
Name: zinc finger protein 251
Synonyms: 9130001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71591
VEGA: 15
Homologene: 87789
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1a1, Oatp1, Slc21a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28248
Homologene: 137261
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, Myhs-e, MyHC-emb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Capn3
Name: calpain 3
Synonyms: p94, Capa-3, Capa3, Lp82
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74052
Homologene: 14728
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, 2700017I06Rik, C230040M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Olfr1329
Name: olfactory receptor 1329
Synonyms: GA_x6K02T2QD9B-18619941-18620882, MOR259-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258214
Homologene: 79401
Olfr749
Name: olfactory receptor 749
Synonyms: MOR106-1, GA_x6K02T2PMLR-6484046-6483105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56858
Homologene: 10652
Serpina3f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3F
Synonyms: alpha-1 antiproteinasin, 2A1, antitrypsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238393
HGNC: HGNC:16
Homologene: 115927
Mrgprb2
Name: MAS-related GPR, member B2
Synonyms: 4833406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243979
Homologene: 86246
Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
Synonyms: Fam59b, LOC242915, Gareml
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242915
Homologene: 19063
Iqce
Name: IQ motif containing E
Synonyms: 1700028P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74239
Homologene: 49912
Sprr2k
Name: small proline-rich protein 2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20765
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Iqca
Name: IQ motif containing with AAA domain
Synonyms: 4930465P12Rik, 4930585L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74918
Homologene: 49784
Olfr1053
Name: olfactory receptor 1053
Synonyms: MOR187-4, GA_x6K02T2Q125-47793414-47792471, Olfr1053-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257974
Homologene: 74197
Capn10
Name: calpain 10
Synonyms: Capn8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23830
HGNC: HGNC:1477
Homologene: 36323
Bsnd
Name: barttin CLCNK type accessory beta subunit
Synonyms: Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140475
Homologene: 14291
Olfr449
Name: olfactory receptor 449
Synonyms: MOR103-1, GA_x6K02T2P3E9-4722003-4721068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 259067
HGNC: HGNC:8354
Homologene: 17485
Rpp21
Name: ribonuclease P 21 subunit
Synonyms: 0610037N01Rik, Rpp21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67676
Homologene: 41592
Acox3
Name: acyl-Coenzyme A oxidase 3, pristanoyl
Synonyms: EST-s59, PCOX, pristanoyl-CoA oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80911
HGNC: HGNC:121
Homologene: 37792
Mvb12b
Name: multivesicular body subunit 12B
Synonyms: 2610528K11Rik, Fam125b, 2610200O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72543
Homologene: 25444
Mucl3
Name: mucin like 3
Synonyms: LOC268949, Dpcr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268949
Homologene: 133813
Crtap
Name: cartilage associated protein
Synonyms: Leprel3, P3h5, CASP, 5730529N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56693
HGNC: HGNC:2379
Homologene: 21280
Ptcd1
Name: pentatricopeptide repeat domain 1
Synonyms: 1110069M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71799
Homologene: 33161
Fen1
Name: flap structure specific endonuclease 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14156
HGNC: HGNC:3650
Homologene: 3034
4930448N21Rik
Name: RIKEN cDNA 4930448N21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 90,070,535 bp
  • A to G, chromosome 1 at 92,943,913 bp
  • A to T, chromosome 2 at 4,300,957 bp
  • T to C, chromosome 2 at 29,914,760 bp
  • T to C, chromosome 2 at 33,827,716 bp
  • T to G, chromosome 2 at 86,315,214 bp
  • G to A, chromosome 2 at 120,484,594 bp
  • T to C, chromosome 3 at 92,433,348 bp
  • G to C, chromosome 4 at 62,306,929 bp
  • T to C, chromosome 4 at 106,488,001 bp
  • C to T, chromosome 4 at 118,916,838 bp
  • A to G, chromosome 5 at 30,116,338 bp
  • T to A, chromosome 5 at 35,605,199 bp
  • T to A, chromosome 5 at 96,820,472 bp
  • A to G, chromosome 5 at 140,690,061 bp
  • A to G, chromosome 5 at 145,154,861 bp
  • C to T, chromosome 6 at 42,838,246 bp
  • A to T, chromosome 6 at 141,922,960 bp
  • C to T, chromosome 7 at 4,485,505 bp
  • A to T, chromosome 7 at 34,245,080 bp
  • T to C, chromosome 7 at 48,552,513 bp
  • C to A, chromosome 7 at 118,846,082 bp
  • T to A, chromosome 7 at 128,140,475 bp
  • T to A, chromosome 8 at 47,413,137 bp
  • A to T, chromosome 9 at 54,376,266 bp
  • T to C, chromosome 9 at 107,558,014 bp
  • T to C, chromosome 9 at 114,378,096 bp
  • G to A, chromosome 9 at 119,941,261 bp
  • G to A, chromosome 10 at 58,485,836 bp
  • A to G, chromosome 10 at 81,370,326 bp
  • A to G, chromosome 11 at 67,088,619 bp
  • A to G, chromosome 12 at 71,945,498 bp
  • A to T, chromosome 12 at 104,216,923 bp
  • A to T, chromosome 12 at 112,775,666 bp
  • A to C, chromosome 13 at 98,789,802 bp
  • T to C, chromosome 14 at 50,737,052 bp
  • A to G, chromosome 15 at 6,783,104 bp
  • A to G, chromosome 15 at 76,870,327 bp
  • T to C, chromosome 16 at 4,650,162 bp
  • T to A, chromosome 17 at 23,821,386 bp
  • T to C, chromosome 17 at 35,638,210 bp
  • T to C, chromosome 17 at 36,256,044 bp
  • T to A, chromosome 18 at 4,169,142 bp
  • A to G, chromosome 18 at 74,654,057 bp
  • A to T, chromosome 19 at 10,200,658 bp
  • T to C, chromosome 19 at 18,988,107 bp
  • A to G, chromosome 19 at 27,421,295 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5733 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043193-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.