Strain Name:
C57BL/6J-MtgxR5744Btlr/Mmmh
Stock Number:
043197-MU
Citation ID:
RRID:MMRRC_043197-MU
Other Names:
R5744 (G1), C57BL/6J-MtgxR5744Btlr
Major Collection:

Gene Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: FYVE-DSP1, 1700092A20Rik, ZFYVE10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74302
VEGA: 11
HGNC: HGNC:7451
Homologene: 23662
Smco3
Name: single-pass membrane protein with coiled-coil domains 3
Synonyms: C030030A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 654818
VEGA: 6
Homologene: 79087
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: Tcfap2b, E130018K07Rik, AP-2(beta)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21419
VEGA: 1
Homologene: 20688
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 6030440P17Rik, my, 8430406N05Rik, ne, b2b1562Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242022
VEGA: 3
Homologene: 18454
Prdm16
Name: PR domain containing 16
Synonyms: csp1, Mel1, 5730557K01Rik, line 27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 70673
VEGA: 4
Homologene: 11139
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 208440
VEGA: 13
Homologene: 40996
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107182
VEGA: 19
Homologene: 31978
Plxna1
Name: plexin A1
Synonyms: PlexA1, Plxn1, NOV, 2600013D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18844
VEGA: 6
HGNC: HGNC:9099
Homologene: 56426
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: TRN2, 1110034O24Rik, Kpnb2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 212999
VEGA: 8
Homologene: 8381
Sel1l
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20338
VEGA: 12
Homologene: 31286
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227720
VEGA: 2
HGNC: HGNC:8064
Homologene: 38008
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67872
VEGA: 7
Homologene: 9745
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
VEGA: 9
HGNC: HGNC:4867
Homologene: 31207
Tomm70a
Name: translocase of outer mitochondrial membrane 70A
Synonyms: Tomm70a, D16Ium22, 2610044B22Rik, D16Ium22e, D16Wsu109e, Tom70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 28185
VEGA: 16
Homologene: 40112
Nol8
Name: nucleolar protein 8
Synonyms: 4921532D18Rik, D13Ertd548e, 5730412B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 70930
VEGA: 13
Homologene: 41210
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229055
VEGA: 3
Homologene: 11395
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216766
VEGA: 11
Homologene: 9155
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 276919
VEGA: 11
Homologene: 69193
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: D0H16S474E, TA1, LAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20539
VEGA: 8
Homologene: 55759
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
VEGA: 5
HGNC: HGNC:9957
Homologene: 3699
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Itpr5, Ip3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16439
VEGA: 6
HGNC: HGNC:6181
Homologene: 37593
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70083
VEGA: 17
Homologene: 11432
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: 0610037M02Rik, Eif3s5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66085
VEGA: 7
HGNC: HGNC:3275
Homologene: 2783
Cgnl1
Name: cingulin-like 1
Synonyms: Jacop, 4933421H10Rik, 9930020M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68178
VEGA: 9
Homologene: 41901
Aldoart2
Name: aldolase 1 A, retrogene 2
Synonyms: Aldoa-ps1, 4933425L11Rik, Aldo1-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 79459
VEGA: 12
Homologene: 134148
Ttyh2
Name: tweety family member 2
Synonyms: 1110001A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 117160
VEGA: 11
Homologene: 41882
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70729
VEGA: 1
Homologene: 135990
Neil1
Name: nei endonuclease VIII-like 1 (E. coli)
Synonyms: 2810450N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72774
VEGA: 9
Homologene: 11616
Csgalnact2
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 2
Synonyms: 4632415D10Rik, Galnact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78752
VEGA: 6
Homologene: 23109
Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
Synonyms: 6OST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50787
VEGA: 14
Homologene: 89201
Il1rap
Name: interleukin 1 receptor accessory protein
Synonyms: 6430709H04Rik, IL-1R AcP, IL-1RAcP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16180
VEGA: 16
HGNC: HGNC:5995
Homologene: 1643
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59056
VEGA: 5
HGNC: HGNC:3497
Homologene: 10949
Olfr1353
Name: olfactory receptor 1353
Synonyms: MOR139-2, GA_x6K02T2QGN0-2842591-2841662
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 259044
VEGA: 10
Homologene: 131345
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Cep2, Inmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16328
VEGA: 2
HGNC: HGNC:1859
Homologene: 38286
Olfr167
Name: olfactory receptor 167
Synonyms: GA_x54KRFPKG5P-15963726-15962788, MOR272-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258937
VEGA: 16
Homologene: 78689
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: D8Ertd91e, 2310066G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 52065
VEGA: 8
Homologene: 3114
Sult1c1
Name: sulfotransferase family, cytosolic, 1C, member 1
Synonyms: P-SULT, Sult1a2, mOLFST, (PST)G, Stp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20888
VEGA: 17
Homologene: 56817
Mn1
Name: meningioma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433938
VEGA: 5
HGNC: HGNC:7180
Homologene: 37620
A530095I07Rik
Name: RIKEN cDNA A530095I07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 210373
VEGA: 13
Tpbpa
Name: trophoblast specific protein alpha
Synonyms: Tb1, Tb-1, 4311, clone 4311, Tpbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21984
VEGA: 13
Homologene: 49203
Olfr825
Name: olfactory receptor 825
Synonyms: MOR210-1, GA_x6K02T2PULF-11834065-11833103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258672
VEGA: 10
Homologene: 121503
Igdcc3
Name: immunoglobulin superfamily, DCC subclass, member 3
Synonyms: WI-14920, Punc, 2810401C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19289
VEGA: 9
HGNC: HGNC:9700
Homologene: 3590
Gm13327
Name: predicted gene 13327
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 19,219,221 bp
  • C to T, chromosome 1 at 170,302,506 bp
  • G to A, chromosome 2 at 21,368,520 bp
  • T to C, chromosome 2 at 32,010,296 bp
  • T to C, chromosome 2 at 155,981,474 bp
  • A to G, chromosome 3 at 9,264,563 bp
  • A to G, chromosome 3 at 53,655,959 bp
  • A to G, chromosome 4 at 154,528,704 bp
  • A to C, chromosome 5 at 22,106,083 bp
  • A to G, chromosome 5 at 37,318,181 bp
  • T to C, chromosome 5 at 111,420,536 bp
  • C to T, chromosome 6 at 89,334,682 bp
  • C to T, chromosome 6 at 118,126,236 bp
  • T to C, chromosome 6 at 136,831,765 bp
  • A to G, chromosome 6 at 146,376,151 bp
  • C to A, chromosome 7 at 108,938,417 bp
  • A to C, chromosome 7 at 130,539,132 bp
  • C to A, chromosome 8 at 35,589,482 bp
  • T to A, chromosome 8 at 85,051,894 bp
  • T to C, chromosome 8 at 121,888,382 bp
  • T to C, chromosome 9 at 57,144,201 bp
  • TGCCGCCGCCGCCGCCGCCGC to TGCCGCCGCCGCCGCCGC, chromosome 9 at 65,141,488 bp
  • C to T, chromosome 9 at 66,508,193 bp
  • G to T, chromosome 9 at 71,630,675 bp
  • T to C, chromosome 10 at 78,970,183 bp
  • T to C, chromosome 10 at 130,162,792 bp
  • A to G, chromosome 11 at 4,487,679 bp
  • C to A, chromosome 11 at 58,155,183 bp
  • A to T, chromosome 11 at 76,212,165 bp
  • T to C, chromosome 11 at 114,702,310 bp
  • A to G, chromosome 12 at 55,565,346 bp
  • A to T, chromosome 12 at 91,809,980 bp
  • A to T, chromosome 13 at 9,568,405 bp
  • A to G, chromosome 13 at 49,662,326 bp
  • C to T, chromosome 13 at 60,935,953 bp
  • G to T, chromosome 13 at 69,543,722 bp
  • T to C, chromosome 14 at 119,138,440 bp
  • A to G, chromosome 16 at 19,515,336 bp
  • A to C, chromosome 16 at 26,680,224 bp
  • G to T, chromosome 16 at 57,121,839 bp
  • A to G, chromosome 17 at 25,795,237 bp
  • T to A, chromosome 17 at 53,973,962 bp
  • T to C, chromosome 19 at 37,004,490 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5744 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043197-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.