Strain Name:
C57BL/6J-MtgxR5749Btlr/Mmmh
Stock Number:
043200-MU
Citation ID:
RRID:MMRRC_043200-MU
Other Names:
R5749 (G1), C57BL/6J-MtgxR5749Btlr
Major Collection:

Gene Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319939
Homologene: 49713
Efnb2
Name: ephrin B2
Synonyms: Epl5, NLERK-1, LERK-5, ELF-2, Htk-L, Eplg5, Lerk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13642
HGNC: HGNC:3227
Homologene: 3019
Ccdc163
Name: coiled-coil domain containing 163
Synonyms: 4933430J04Rik, 0610037D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68394
Homologene: 12265
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: EHSH1, Sh3p17, Ese1, Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12808
Homologene: 9058
Gtpbp4
Name: GTP binding protein 4
Synonyms: 2610028C09Rik, Crfg, Nog1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69237
VEGA: 13
Homologene: 7100
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: Uchrp, 2610014N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22224
Homologene: 31294
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83675
Homologene: 12856
Pxylp1
Name: 2-phosphoxylose phosphatase 1
Synonyms: 9430094M07Rik, C130099A20Rik, Acpl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235534
Homologene: 15931
Cyhr1
Name: cysteine and histidine rich 1
Synonyms: Chrp, 1110031M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54151
Homologene: 32791
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, 3000002A17Rik, X83317, Crsp3, Sur2, sno
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Marchf7
Name: membrane associated ring-CH-type finger 7
Synonyms: Axot, Gtrgeo17, March7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57438
Homologene: 10753
Prlr
Name: prolactin receptor
Synonyms: Pr-1, Prlr-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19116
HGNC: HGNC:9446
Homologene: 733
Ppara
Name: peroxisome proliferator activated receptor alpha
Synonyms: Nr1c1, PPAR-alpha, PPARalpha, Ppar, 4933429D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19013
HGNC: HGNC:9232
Homologene: 21047
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 665113
Homologene: 77943
Myo16
Name: myosin XVI
Synonyms: C230040D10Rik, Nyap3, BM140241
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244281
Homologene: 34710
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: Epac2, cAMP-GEFII, 1300003D15Rik, 5730402K07Rik, 6330581N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56508
Homologene: 4451
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71957
Homologene: 9894
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Stap2
Name: signal transducing adaptor family member 2
Synonyms: STAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106766
VEGA: 17
Homologene: 9798
Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13090
Homologene: 104114
Fem1b
Name: fem 1 homolog b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14155
VEGA: 9
HGNC: HGNC:3649
Homologene: 7714
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72772
Homologene: 11070
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627132
Homologene: 129750
St8sia3
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Synonyms: ST8SiaIII, Siat8c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20451
Homologene: 8285
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233437
Homologene: 115466
Prss36
Name: protease, serine 36
Synonyms: polyserase-2, C330007D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77613
Homologene: 18303
Fbxo17
Name: F-box protein 17
Synonyms: Fbx17, FBXO26, Fbg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50760
Homologene: 17523
Lbp
Name: lipopolysaccharide binding protein
Synonyms: Bpifd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16803
HGNC: HGNC:6517
Homologene: 3055
Olfr1448
Name: olfactory receptor 1448
Synonyms: GA_x6K02T2RE5P-3249780-3248836, MOR202-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258696
Homologene: 64904
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384534
Homologene: 129605
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4930549K11Rik, 4930554C01Rik, 4932423M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75338
Homologene: 32709
Olfr1510
Name: olfactory receptor 1510
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Olfr1113
Name: olfactory receptor 1113
Synonyms: GA_x6K02T2Q125-48697747-48698727, MOR264-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404327
Homologene: 27114
Fam90a1a
Name: family with sequence similarity 90, member A1A
Synonyms: C86695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 97476
Homologene: 135718
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216739
Homologene: 100939
Tgfbr3l
Name: transforming growth factor, beta receptor III-like
Synonyms: LOC100039590, Gm14378
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100044509
Homologene: 130375
Psg25
Name: pregnancy-specific glycoprotein 25
Synonyms: cea13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114868
Homologene: 110989
Zfp697
Name: zinc finger protein 697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242109
Homologene: 18241
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin1, Pyhin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
Klk1b16
Name: kallikrein 1-related peptidase b16
Synonyms: mGk-16, Klk16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16615
HGNC: HGNC:6364
Homologene: 68141
Olfr768
Name: olfactory receptor 768
Synonyms: GA_x6K02T2PULF-10779441-10778503, MOR114-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258863
Homologene: 17159
Gm9748
Name: predicted gene 9748
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 102633266
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 173,637,327 bp
  • T to C, chromosome 2 at 12,262,078 bp
  • T to C, chromosome 2 at 60,234,176 bp
  • A to T, chromosome 2 at 72,242,757 bp
  • C to T, chromosome 2 at 87,212,943 bp
  • A to G, chromosome 2 at 120,703,786 bp
  • T to A, chromosome 2 at 158,319,753 bp
  • T to C, chromosome 3 at 28,594,092 bp
  • T to C, chromosome 3 at 98,425,464 bp
  • T to A, chromosome 4 at 116,714,112 bp
  • T to C, chromosome 4 at 155,872,246 bp
  • C to T, chromosome 5 at 23,794,307 bp
  • C to T, chromosome 7 at 10,159,032 bp
  • T to C, chromosome 7 at 18,524,851 bp
  • T to C, chromosome 7 at 26,763,419 bp
  • G to A, chromosome 7 at 28,737,472 bp
  • T to C, chromosome 7 at 44,140,786 bp
  • T to A, chromosome 7 at 85,006,771 bp
  • T to C, chromosome 7 at 90,223,948 bp
  • T to A, chromosome 7 at 127,933,642 bp
  • A to G, chromosome 8 at 4,249,310 bp
  • A to C, chromosome 8 at 8,639,347 bp
  • C to T, chromosome 8 at 10,413,245 bp
  • T to A, chromosome 8 at 21,963,041 bp
  • G to A, chromosome 8 at 119,941,133 bp
  • A to G, chromosome 9 at 62,797,006 bp
  • A to G, chromosome 9 at 96,856,371 bp
  • T to C, chromosome 10 at 24,888,449 bp
  • A to G, chromosome 10 at 70,946,969 bp
  • A to T, chromosome 10 at 129,093,097 bp
  • A to T, chromosome 11 at 8,451,177 bp
  • A to G, chromosome 11 at 12,266,965 bp
  • G to A, chromosome 11 at 54,324,055 bp
  • A to G, chromosome 13 at 8,995,947 bp
  • T to A, chromosome 14 at 50,844,072 bp
  • T to A, chromosome 14 at 52,410,504 bp
  • T to C, chromosome 14 at 79,770,085 bp
  • T to A, chromosome 15 at 10,328,718 bp
  • A to C, chromosome 15 at 76,658,644 bp
  • A to T, chromosome 15 at 85,789,028 bp
  • T to A, chromosome 16 at 91,906,855 bp
  • T to A, chromosome 17 at 18,298,284 bp
  • T to A, chromosome 17 at 55,995,849 bp
  • T to C, chromosome 17 at 65,986,096 bp
  • A to T, chromosome 18 at 64,266,929 bp
  • A to G, chromosome 19 at 12,920,225 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5749 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043200-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.