Strain Name:
C57BL/6J-MtgxR5785Btlr/Mmmh
Stock Number:
043206-MU
Citation ID:
RRID:MMRRC_043206-MU
Other Names:
R5785 (G1), C57BL/6J-MtgxR5785Btlr
Major Collection:

Gene Information

Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20586
Homologene: 135927
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223666
Homologene: 27825
Mbd2
Name: methyl-CpG binding domain protein 2
Synonyms: MBD2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17191
HGNC: HGNC:6917
Homologene: 2918
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71807
Homologene: 23520
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Dek
Name: DEK proto-oncogene (DNA binding)
Synonyms: D13H6S231E, 1810019E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110052
HGNC: HGNC:2768
Homologene: 2593
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Agk
Name: acylglycerol kinase
Synonyms: MuLK, 2610037M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69923
Homologene: 41239
Nodal
Name: nodal
Synonyms: Tg.413d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18119
HGNC: HGNC:7865
Homologene: 8417
Onecut1
Name: one cut domain, family member 1
Synonyms: HNF6, Hnf6, Hfh12, D9Ertd423e, Oc1, OC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15379
HGNC: HGNC:8138
Homologene: 3309
Hhip
Name: Hedgehog-interacting protein
Synonyms: Hip, Hip1, Hhip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15245
Homologene: 32469
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67163
Homologene: 41351
Zfp507
Name: zinc finger protein 507
Synonyms: A230056M16Rik, 1810022O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668501
Homologene: 8942
Cwf19l1
Name: CWF19-like 1, cell cycle control (S. pombe)
Synonyms: 2610528C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: mMCL, Mpcl, Clecsf8, mcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17474
Homologene: 7844
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, Nafld, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Or9q1
Name: olfactory receptor family 9 subfamily Q member 1
Synonyms: GA_x6K02T2RE5P-4160554-4159619, MOR212-4P, Olfr1500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258097
Homologene: 72644
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49A, Ly49o129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16627
Homologene: 110821
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Trim80
Name: tripartite motif-containing 80
Synonyms: 4933422H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432613
Homologene: 46325
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 637004
Il36b
Name: interleukin 36B
Synonyms: 2310043N20Rik, Il1f8, If36b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69677
Homologene: 18278
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75033
Homologene: 87251
Apbb1
Name: amyloid beta (A4) precursor protein-binding, family B, member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240753
Homologene: 135779
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Ndufa10
Name: NADH:ubiquinone oxidoreductase subunit A10
Synonyms: 2900053E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67273
HGNC: HGNC:7684
Homologene: 15342
Hdac10
Name: histone deacetylase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170787
Homologene: 23749
Mx2
Name: MX dynamin-like GTPase 2
Synonyms: Mx-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17858
HGNC: HGNC:7532
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244418
Homologene: 18256
Esp18
Name: exocrine gland secreted peptide 18
Synonyms: Gm20579
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126774
VEGA: 17
Jchain
Name: immunoglobulin joining chain
Synonyms: Jch, J chain, 9530090F24Rik, Igj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16069
HGNC: HGNC:5713
Homologene: 16958
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Cers4
Name: ceramide synthase 4
Synonyms: 2900019C14Rik, Trh1, CerS4, Lass4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67260
Homologene: 11582
Syt12
Name: synaptotagmin XII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171180
Homologene: 15895
Vmn2r130
Name: vomeronasal 2, receptor 130
Synonyms: Vmn2r-ps130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100042225
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, IR10, 9030208C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
Synonyms: LOC333424, alpha4GnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333424
Homologene: 87446
Gm5852
Name: predicted gene 5852
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545550
Dhx58os
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 58, opposite strand
Synonyms: Gm11547
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 92,460,374 bp
  • G to C, chromosome 1 at 133,272,307 bp
  • T to C, chromosome 1 at 181,139,298 bp
  • G to A, chromosome 2 at 24,154,649 bp
  • A to C, chromosome 2 at 66,697,568 bp
  • A to G, chromosome 2 at 67,509,662 bp
  • T to A, chromosome 2 at 118,609,844 bp
  • T to A, chromosome 3 at 64,259,023 bp
  • T to G, chromosome 3 at 93,727,767 bp
  • T to C, chromosome 3 at 95,748,604 bp
  • A to T, chromosome 4 at 46,564,691 bp
  • T to C, chromosome 5 at 88,522,517 bp
  • G to A, chromosome 5 at 104,968,170 bp
  • T to C, chromosome 6 at 40,347,499 bp
  • A to G, chromosome 6 at 123,274,770 bp
  • T to C, chromosome 6 at 130,364,241 bp
  • A to G, chromosome 7 at 17,027,691 bp
  • A to G, chromosome 7 at 35,787,742 bp
  • C to A, chromosome 7 at 105,567,715 bp
  • T to A, chromosome 8 at 4,516,992 bp
  • A to G, chromosome 8 at 36,103,487 bp
  • T to A, chromosome 8 at 79,998,192 bp
  • C to A, chromosome 8 at 95,254,195 bp
  • T to A, chromosome 9 at 21,394,872 bp
  • T to C, chromosome 9 at 21,686,026 bp
  • C to T, chromosome 9 at 74,863,392 bp
  • A to G, chromosome 9 at 82,025,547 bp
  • A to T, chromosome 9 at 99,620,672 bp
  • T to C, chromosome 9 at 103,323,528 bp
  • A to G, chromosome 9 at 108,827,797 bp
  • G to A, chromosome 10 at 41,451,853 bp
  • A to G, chromosome 10 at 61,423,677 bp
  • A to G, chromosome 11 at 100,697,173 bp
  • G to A, chromosome 11 at 106,204,880 bp
  • C to T, chromosome 11 at 115,446,475 bp
  • T to C, chromosome 12 at 98,682,550 bp
  • A to G, chromosome 13 at 47,101,725 bp
  • T to C, chromosome 15 at 76,737,418 bp
  • A to T, chromosome 15 at 89,126,945 bp
  • A to T, chromosome 16 at 97,538,704 bp
  • T to A, chromosome 17 at 23,061,487 bp
  • T to C, chromosome 17 at 24,599,887 bp
  • C to T, chromosome 17 at 39,409,948 bp
  • T to C, chromosome 18 at 70,616,606 bp
  • T to C, chromosome 19 at 4,450,994 bp
  • T to C, chromosome 19 at 13,827,619 bp
  • A to G, chromosome 19 at 44,121,941 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5785 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043206-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.