Strain Name:
C57BL/6J-MtgxR5791Btlr/Mmmh
Stock Number:
043207-MU
Citation ID:
RRID:MMRRC_043207-MU
Other Names:
R5791 (G1), C57BL/6J-MtgxR5791Btlr
Major Collection:

Gene Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1, NFATp, NFAT1-D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Tln2
Name: talin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Adipor2
Name: adiponectin receptor 2
Synonyms: D6Ucla1e, 1110001I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68465
Homologene: 56119
Wasf1
Name: WASP family, member 1
Synonyms: WAVE-1, Scar, WAVE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83767
Homologene: 2920
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Rnf103
Name: ring finger protein 103
Synonyms: kf-1, Zfp103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22644
Homologene: 4146
Gfral
Name: GDNF family receptor alpha like
Synonyms: GRAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404194
Homologene: 45748
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: NLRR-2, 5730406J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16980
Homologene: 21274
Retreg3
Name: reticulophagy regulator family member 3
Synonyms: Fam134c, 1300010M03Rik, 4933404C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67998
Homologene: 23585
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Eea1
Name: early endosome antigen 1
Synonyms: ZFYVE2, A430109M19Rik, B230358H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Kcng3
Name: potassium voltage-gated channel, subfamily G, member 3
Synonyms: Kv10.1a, Kv10.1b, KV6.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225030
VEGA: 17
Homologene: 15168
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: sals, nmf112, nmf181, nmf252, 4930542A03Rik, ahl, USH1D, mdfw, bob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54598
Homologene: 21179
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Olfr980
Name: olfactory receptor 980
Synonyms: MOR223-2, GA_x6K02T2PVTD-33705428-33704496
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259110
VEGA: 9
Homologene: 81557
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: 6720461J18Rik, Parg1, B130017I01Rik, C76601
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214137
Homologene: 3539
Gas6
Name: growth arrest specific 6
Synonyms: Gas-6, growth arrest-specific, GAS 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14456
HGNC: HGNC:4168
Homologene: 638
Fbxw26
Name: F-box and WD-40 domain protein 26
Synonyms: Gm5163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382109
Homologene: 110776
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242838
Homologene: 18247
Zfp14
Name: zinc finger protein 14
Synonyms: Krox-9, Zfp-14, 4732429I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243906
Homologene: 45619
Adam25
Name: a disintegrin and metallopeptidase domain 25 (testase 2)
Synonyms: testase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Cdh4
Name: cadherin 4
Synonyms: R-cadherin, Rcad, R-Cadh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Vwde
Name: von Willebrand factor D and EGF domains
Synonyms: LOC232585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232585
Homologene: 35456
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 378431
Homologene: 44534
Ppox
Name: protoporphyrinogen oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19044
HGNC: HGNC:9280
Homologene: 262
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Fam149b
Name: family with sequence similarity 149, member B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105428
VEGA: 14
Homologene: 67023
Mab21l2
Name: mab-21-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23937
HGNC: HGNC:6758
Homologene: 7824
Tex26
Name: testis expressed 26
Synonyms: 4930588N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75860
Homologene: 51841
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215008
Homologene: 9739
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: 1200011O22Rik, Orca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71735
Homologene: 17678
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: 4921530D09Rik, Cccd183
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77058
Homologene: 50023
Gmppa
Name: GDP-mannose pyrophosphorylase A
Synonyms: 1810012N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69080
Homologene: 8346
Coasy
Name: Coenzyme A synthase
Synonyms: 1300003G02Rik, Ukr1, Ppat, Dpck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71743
Homologene: 11889
Ndufv3
Name: NADH:ubiquinone oxidoreductase core subunit V3
Synonyms: 1500032D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78330
HGNC: HGNC:7719
Homologene: 10885
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,442,255 bp
  • A to G, chromosome 1 at 132,937,767 bp
  • T to C, chromosome 1 at 171,277,312 bp
  • T to C, chromosome 2 at 25,616,265 bp
  • A to T, chromosome 2 at 84,351,265 bp
  • T to A, chromosome 2 at 168,536,393 bp
  • T to C, chromosome 2 at 179,895,767 bp
  • A to G, chromosome 3 at 86,546,737 bp
  • T to A, chromosome 3 at 122,014,245 bp
  • C to T, chromosome 4 at 58,814,027 bp
  • T to A, chromosome 4 at 58,822,111 bp
  • T to C, chromosome 5 at 3,851,254 bp
  • G to C, chromosome 5 at 136,131,033 bp
  • A to T, chromosome 5 at 149,439,775 bp
  • C to A, chromosome 6 at 13,195,986 bp
  • C to A, chromosome 6 at 71,508,925 bp
  • A to T, chromosome 6 at 119,361,905 bp
  • T to A, chromosome 7 at 13,339,692 bp
  • A to G, chromosome 7 at 30,038,262 bp
  • T to C, chromosome 7 at 119,931,473 bp
  • A to G, chromosome 8 at 13,470,217 bp
  • G to C, chromosome 8 at 40,754,220 bp
  • A to T, chromosome 9 at 40,006,734 bp
  • A to T, chromosome 9 at 67,386,605 bp
  • C to T, chromosome 9 at 76,197,046 bp
  • T to C, chromosome 9 at 107,025,349 bp
  • A to G, chromosome 9 at 109,745,153 bp
  • T to C, chromosome 10 at 17,799,128 bp
  • G to A, chromosome 10 at 40,926,574 bp
  • T to A, chromosome 10 at 60,303,566 bp
  • T to C, chromosome 10 at 93,994,993 bp
  • T to A, chromosome 10 at 96,019,995 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • A to G, chromosome 11 at 101,084,385 bp
  • A to G, chromosome 11 at 101,100,943 bp
  • A to G, chromosome 14 at 20,351,326 bp
  • G to T, chromosome 15 at 76,918,006 bp
  • A to T, chromosome 17 at 24,704,434 bp
  • A to G, chromosome 17 at 31,527,408 bp
  • A to G, chromosome 17 at 83,588,210 bp
  • G to T, chromosome 18 at 37,692,340 bp
  • A to G, chromosome 19 at 15,961,072 bp
  • T to A, chromosome 19 at 47,110,991 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5791 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043207-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.