Strain Name:
C57BL/6J-MtgxR5871Btlr/Mmmh
Stock Number:
043234-MU
Citation ID:
RRID:MMRRC_043234-MU
Other Names:
R5871 (G1), C57BL/6J-MtgxR5871Btlr
Major Collection:

Gene Information

Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Usp14
Name: ubiquitin specific peptidase 14
Synonyms: dUB-type TGT, 2610005K12Rik, ataxia, ax, NMF375, 2610037B11Rik, nmf375
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 59025
Homologene: 3780
Esrrb
Name: estrogen related receptor, beta
Synonyms: Estrrb, ERRb, ERR2, Err2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26380
HGNC: HGNC:3473
Homologene: 69108
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233900
Homologene: 8856
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 9530001P15Rik, 2310065E01Rik, Ponsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Plcg2
Name: phospholipase C, gamma 2
Synonyms: Plcg-2, PLCgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, SR-AI, MSR-A, Scara1, Scvr, MRS-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52357
Homologene: 32618
Ackr1
Name: atypical chemokine receptor 1 (Duffy blood group)
Synonyms: CCBP1, FY, CD234, ESTM35, Dfy, Darc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13349
HGNC: HGNC:4035
Homologene: 48067
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: HO57, Atp6b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Ubxn1
Name: UBX domain protein 1
Synonyms: T25529, 4930455J02Rik, D19Ertd721e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225896
VEGA: 19
Homologene: 9283
Anxa5
Name: annexin A5
Synonyms: Anx5, annexin V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11747
HGNC: HGNC:543
Homologene: 20312
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: MFT.M05.13, Hcapg, 5730507H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54392
Homologene: 44071
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
Lcorl
Name: ligand dependent nuclear receptor corepressor-like
Synonyms: Mlr1, A830039H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209707
Homologene: 82325
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233186
Homologene: 50482
Rpgrip1l
Name: Rpgrip1-like
Synonyms: Ftm, 1700047E16Rik, fantom, Nphp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244585
Homologene: 18296
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 332221
Homologene: 13122
Ccr5
Name: chemokine (C-C motif) receptor 5
Synonyms: CD195, Cmkbr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12774
HGNC: HGNC:1606
Homologene: 37325
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Olfr679
Name: olfactory receptor 679
Synonyms: GA_x6K02T2PBJ9-7714499-7715446, MOR40-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259046
Homologene: 81538
Supv3l1
Name: suppressor of var1, 3-like 1 (S. cerevisiae)
Synonyms: 6330443E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338359
Homologene: 2386
Fam76a
Name: family with sequence similarity 76, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230789
Homologene: 27071
Tbrg1
Name: transforming growth factor beta regulated gene 1
Synonyms: TB-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21376
Homologene: 18102
Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
Synonyms: p55pik, p55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18710
HGNC: HGNC:8981
Homologene: 2690
Ldlrap1
Name: low density lipoprotein receptor adaptor protein 1
Synonyms: Arh1, Arh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100017
Homologene: 9219
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 665119
VEGA: 16
Homologene: 96163
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12722
Homologene: 77224
Pth2r
Name: parathyroid hormone 2 receptor
Synonyms: Pthr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213527
HGNC: HGNC:9609
Homologene: 3701
Nfam1
Name: Nfat activating molecule with ITAM motif 1
Synonyms: Nfam1, 4921501M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74039
Homologene: 12528
Bend6
Name: BEN domain containing 6
Synonyms: B230209C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320705
Homologene: 27394
Olfr1294
Name: olfactory receptor 1294
Synonyms: GA_x6K02T2Q125-72589785-72588847, MOR248-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258887
Homologene: 74216
Olfr1158
Name: olfactory receptor 1158
Synonyms: GA_x6K02T2Q125-49480812-49481753, MOR173-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258639
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 9530062N20Rik, 1110054G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68770
Homologene: 10713
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Achr-3, Acrg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Ankrd13d
Name: ankyrin repeat domain 13 family, member D
Synonyms: 0710001P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68423
Homologene: 27612
Ugt1a7c
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C
Synonyms: A10'
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394432
Homologene: 136043
Olfr913
Name: olfactory receptor 913
Synonyms: GA_x6K02T2PVTD-32296575-32297513, MOR165-9P, MOR165-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258225
VEGA: 9
Homologene: 79398
Fgf9
Name: fibroblast growth factor 9
Synonyms: glia activating factor, Eks
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14180
HGNC: HGNC:3687
Homologene: 1523
Gatb
Name: glutamyl-tRNA(Gln) amidotransferase, subunit B
Synonyms: 9430026F02Rik, Pet112l, Pet112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 33,863,865 bp
  • C to T, chromosome 1 at 65,388,637 bp
  • C to A, chromosome 1 at 80,541,340 bp
  • T to C, chromosome 1 at 87,206,729 bp
  • A to G, chromosome 1 at 88,095,659 bp
  • A to T, chromosome 1 at 173,332,073 bp
  • T to C, chromosome 2 at 87,991,011 bp
  • A to G, chromosome 2 at 111,537,639 bp
  • T to A, chromosome 3 at 36,452,249 bp
  • G to T, chromosome 3 at 59,330,411 bp
  • T to A, chromosome 3 at 85,653,776 bp
  • T to G, chromosome 3 at 144,754,881 bp
  • G to T, chromosome 4 at 116,286,158 bp
  • T to C, chromosome 4 at 132,904,010 bp
  • A to G, chromosome 4 at 134,758,929 bp
  • A to G, chromosome 5 at 20,794,401 bp
  • A to G, chromosome 5 at 45,695,697 bp
  • A to G, chromosome 5 at 45,727,508 bp
  • G to A, chromosome 5 at 120,555,990 bp
  • A to G, chromosome 6 at 113,556,282 bp
  • T to C, chromosome 7 at 43,355,621 bp
  • T to C, chromosome 7 at 105,086,304 bp
  • T to A, chromosome 7 at 127,591,585 bp
  • G to A, chromosome 8 at 39,611,652 bp
  • A to G, chromosome 8 at 47,868,423 bp
  • C to T, chromosome 8 at 69,105,916 bp
  • T to C, chromosome 8 at 91,221,386 bp
  • T to A, chromosome 8 at 117,504,217 bp
  • A to G, chromosome 9 at 37,650,982 bp
  • T to A, chromosome 9 at 38,594,332 bp
  • C to A, chromosome 9 at 95,861,509 bp
  • T to C, chromosome 9 at 124,124,521 bp
  • A to G, chromosome 10 at 62,430,694 bp
  • T to C, chromosome 11 at 77,832,480 bp
  • T to C, chromosome 11 at 103,616,454 bp
  • A to G, chromosome 12 at 86,505,887 bp
  • A to T, chromosome 14 at 58,083,199 bp
  • G to A, chromosome 15 at 47,888,716 bp
  • A to G, chromosome 15 at 83,016,422 bp
  • T to A, chromosome 16 at 5,168,853 bp
  • A to G, chromosome 17 at 23,607,267 bp
  • T to A, chromosome 18 at 5,103,669 bp
  • A to G, chromosome 18 at 9,996,234 bp
  • A to G, chromosome 19 at 4,281,994 bp
  • A to G, chromosome 19 at 8,874,212 bp
  • A to G, chromosome 19 at 40,398,583 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5871 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043234-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.