Strain Name:
C57BL/6J-MtgxR5922Btlr/Mmmh
Stock Number:
043240-MU
Citation ID:
RRID:MMRRC_043240-MU
Other Names:
R5922 (G1), C57BL/6J-MtgxR5922Btlr
Major Collection:

Strain Information

Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4933439E17Rik, 4930513H15Rik, D14Ertd581e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Vmp1
Name: vacuole membrane protein 1
Synonyms: 4930579A11Rik, 3110098I04Rik, Tmem49, Tango5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75909
Homologene: 23686
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Ern1
Name: endoplasmic reticulum (ER) to nucleus signalling 1
Synonyms: 9030414B18Rik, Ire1p, Ire1alpha, Ire1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Scimp
Name: SLP adaptor and CSK interacting membrane protein
Synonyms: A430084P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327957
Homologene: 52602
Ms4a6b
Name: membrane-spanning 4-domains, subfamily A, member 6B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69774
Homologene: 128306
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Prss14, Epithin, MT-SP1, matriptase, Tmprss14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19143
Homologene: 7906
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80517
VEGA: 9
Homologene: 10756
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60344
Homologene: 5813
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Fmnl3
Name: formin-like 3
Synonyms: 2700073B04Rik, Wbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22379
Homologene: 69101
Actl7a
Name: actin-like 7a
Synonyms: Tact2, t-actin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11470
HGNC: HGNC:161
Homologene: 7613
Heatr9
Name: HEAT repeat containing 9
Synonyms: Gm11435
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 629303
Homologene: 51895
Ush1c
Name: USH1 protein network component harmonin
Synonyms: 2010016F01Rik, harmonin, Usher syndrome 1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72088
Homologene: 77476
Zfp712
Name: zinc finger protein 712
Synonyms: 4921504N20Rik, mszf31, mszf89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Serpina3i
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3I
Synonyms: 2B2, antitrypsin, alpha-1 antiproteinase, Gm6930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 628900
HGNC: HGNC:16
Homologene: 115927
Hpx
Name: hemopexin
Synonyms: hx, Hpxn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
Fam98c
Name: family with sequence similarity 98, member C
Synonyms: B230110F21Rik, 1110006G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73833
Homologene: 45483
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: UGT1.6, Ugt1a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94284
Homologene: 85959
Msh5
Name: mutS homolog 5
Synonyms: G7, Mut5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319634
Homologene: 63366
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240843
Homologene: 10905
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, C230095H21Rik, 6330578D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 140580
Homologene: 56685
Nexn
Name: nexilin
Synonyms: nF actin binding protein, 1110046H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68810
Homologene: 44892
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Dus2
Name: dihydrouridine synthase 2
Synonyms: 2310016K04Rik, Dus2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66369
Homologene: 6838
Sec61a2
Name: Sec61, alpha subunit 2 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57743
Homologene: 38481
Hyal2
Name: hyaluronoglucosaminidase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15587
HGNC: HGNC:5321
Homologene: 7776
Col25a1
Name: collagen, type XXV, alpha 1
Synonyms: 2700062B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77018
Homologene: 57111
Pdlim7
Name: PDZ and LIM domain 7
Synonyms: 2410002J21Rik, 1110003B01Rik, Enigma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67399
Homologene: 3980
Plrg1
Name: pleiotropic regulator 1
Synonyms: Tango4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53317
HGNC: HGNC:9089
Homologene: 2004
Paqr6
Name: progestin and adipoQ receptor family member VI
Synonyms: 1500001B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68957
Homologene: 19746
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 213765
Homologene: 18185
Etnk2
Name: ethanolamine kinase 2
Synonyms: 4933417N20Rik, Eki2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214253
Homologene: 10072
Spz1
Name: spermatogenic leucine zipper 1
Synonyms: 1700027M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 79401
VEGA: 13
Homologene: 49934
Cpn1
Name: carboxypeptidase N, polypeptide 1
Synonyms: CPN, 50 kDa, 0610011F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93721
HGNC: HGNC:2312
Homologene: 1002
Gjb2
Name: gap junction protein, beta 2
Synonyms: connexin 26, Cx26, Gjb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14619
HGNC: HGNC:4284
Homologene: 2975
Ptges3-ps
Name: prostaglandin E synthase 3, pseudogene
Synonyms: Gm9769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043508
Homologene: 128197
Igkv14-130
Name: immunoglobulin kappa variable 14-130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 628072
Dnal1
Name: dynein, axonemal, light chain 1
Synonyms: E330027P08Rik, 1700010H15Rik, Dnal1, Dnalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 105000
Homologene: 34623
BE692007
Name: expressed sequence BE692007
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100504727
1810062O18Rik
Name: RIKEN cDNA 1810062O18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75602
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 88,215,788 bp
  • A to G, chromosome 1 at 133,363,885 bp
  • A to T, chromosome 1 at 158,249,355 bp
  • A to T, chromosome 2 at 5,874,323 bp
  • T to C, chromosome 2 at 26,415,639 bp
  • T to C, chromosome 2 at 63,979,060 bp
  • T to C, chromosome 2 at 112,249,314 bp
  • T to A, chromosome 3 at 83,056,848 bp
  • G to T, chromosome 3 at 88,366,237 bp
  • C to T, chromosome 3 at 130,182,841 bp
  • C to A, chromosome 3 at 152,252,753 bp
  • G to T, chromosome 4 at 56,743,827 bp
  • T to C, chromosome 6 at 67,791,222 bp
  • T to G, chromosome 6 at 85,844,120 bp
  • T to G, chromosome 6 at 85,844,159 bp
  • T to C, chromosome 7 at 29,154,344 bp
  • A to T, chromosome 7 at 46,204,128 bp
  • A to G, chromosome 7 at 102,154,017 bp
  • C to T, chromosome 7 at 105,595,624 bp
  • G to A, chromosome 8 at 106,053,405 bp
  • C to T, chromosome 8 at 108,946,698 bp
  • G to A, chromosome 9 at 25,108,984 bp
  • A to T, chromosome 9 at 31,129,904 bp
  • A to G, chromosome 9 at 95,903,682 bp
  • A to G, chromosome 9 at 107,570,907 bp
  • T to A, chromosome 10 at 21,152,927 bp
  • A to C, chromosome 11 at 70,800,816 bp
  • T to C, chromosome 11 at 77,188,744 bp
  • C to T, chromosome 11 at 83,512,367 bp
  • A to G, chromosome 11 at 86,643,491 bp
  • T to C, chromosome 11 at 106,421,730 bp
  • C to A, chromosome 12 at 84,126,972 bp
  • A to G, chromosome 12 at 104,266,507 bp
  • A to G, chromosome 13 at 20,605,169 bp
  • A to G, chromosome 13 at 55,247,475 bp
  • G to T, chromosome 13 at 55,508,955 bp
  • G to T, chromosome 13 at 67,041,604 bp
  • A to T, chromosome 13 at 92,575,598 bp
  • T to C, chromosome 14 at 20,552,071 bp
  • C to T, chromosome 14 at 54,946,474 bp
  • A to G, chromosome 14 at 57,100,298 bp
  • A to G, chromosome 14 at 99,137,088 bp
  • G to A, chromosome 15 at 99,325,646 bp
  • G to T, chromosome 17 at 35,030,630 bp
  • T to C, chromosome 19 at 11,483,661 bp
  • T to A, chromosome 19 at 11,520,379 bp
  • T to C, chromosome 19 at 43,986,093 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5922 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043240-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.