Strain Name:
C57BL/6J-MtgxR5961Btlr/Mmmh
Stock Number:
043247-MU
Citation ID:
RRID:MMRRC_043247-MU
Other Names:
R5961 (G1), C57BL/6J-MtgxR5961Btlr
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Dnajc17
Name: DnaJ heat shock protein family (Hsp40) member C17
Synonyms: D9Bwg1371e, 1700025B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69408
Homologene: 49527
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74996
Homologene: 9929
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Jhdm1b, Fbxl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 30841
Homologene: 13069
Vps53
Name: VPS53 GARP complex subunit
Synonyms: 2310040I21Rik, 2010002A08Rik, 3100002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68299
Homologene: 6264
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Aen
Name: apoptosis enhancing nuclease
Synonyms: 2700083B06Rik, Isg20l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68048
Homologene: 23382
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71960
Homologene: 23480
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Mmadhc
Name: methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
Synonyms: 2010311D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109129
Homologene: 9248
Prokr2
Name: prokineticin receptor 2
Synonyms: PKR2, B830005M06Rik, EG-VEGRF2, Gpr73l1, Gpcr73l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 246313
Homologene: 16368
Mlec
Name: malectin
Synonyms: ESTM19, 2410014A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109154
Homologene: 8823
Ostm1
Name: osteopetrosis associated transmembrane protein 1
Synonyms: gl, 1200002H13Rik, HSPC019
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14628
Homologene: 32203
Rbis
Name: ribosomal biogenesis factor
Synonyms: 1810022K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69126
Homologene: 47794
Klhl2
Name: kelch-like 2, Mayven
Synonyms: ABP-KELCH, 6030411N21Rik, Mav, 8530402H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77113
HGNC: HGNC:6353
Homologene: 21416
Caprin2
Name: caprin family member 2
Synonyms: Eeg1, C1qdc1, RNG140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232560
Homologene: 11393
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv-2, Ron, CDw136, friend virus susceptibility 2, PTK8, Fv2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ackr4
Name: atypical chemokine receptor 4
Synonyms: VSHK1, CCR11, CCBP2, PPR1, CCX-CKR, A630091E18Rik, Ccrl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Exph5
Name: exophilin 5
Synonyms: slac2-b, B130009M24Rik, AC079869.22gm5, Slac2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320051
Homologene: 9007
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20849
Homologene: 20679
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist1, Egfr-rs, Dist
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13650
Homologene: 32085
Or6c209
Name: olfactory receptor family 6 subfamily C member 209
Synonyms: GA_x6K02T2PULF-11325750-11326685, MOR114-2, Olfr799
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258929
Homologene: 37000
Mfsd6l
Name: major facilitator superfamily domain containing 6-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215723
Homologene: 17128
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Fam83a
Name: family with sequence similarity 83, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239463
Homologene: 13158
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, 1700062G21Rik, A230068P09Rik, 9330127H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Alkbh6
Name: alkB homolog 6
Synonyms: Abh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233065
Homologene: 15555
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77593
Homologene: 17674
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231396
Homologene: 128251
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: GGT, CD224, Ggtp, dwg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14598
Homologene: 68450
Ido2
Name: indoleamine 2,3-dioxygenase 2
Synonyms: C230043N17Rik, Ido2, Indol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209176
Homologene: 48830
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101502
Homologene: 41617
Atxn7l2
Name: ataxin 7-like 2
Synonyms: 2610528J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72522
Homologene: 17728
Mlx
Name: MAX-like protein X
Synonyms: BigMax alpha, Tcfl4, bHLHd13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21428
Homologene: 7969
Maf1
Name: MAF1 homolog, negative regulator of RNA polymerase III
Synonyms: 1110068E11Rik, Maf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68877
Homologene: 49867
Pycr2
Name: pyrroline-5-carboxylate reductase family, member 2
Synonyms: 1810018M05Rik, P5cr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69051
Homologene: 8343
Mroh6
Name: maestro heat-like repeat family member 6
Synonyms: Gm19570
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223645
Homologene: 90414
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,065,384 bp
  • C to G, chromosome 1 at 180,907,621 bp
  • T to C, chromosome 2 at 50,291,409 bp
  • A to G, chromosome 2 at 82,258,002 bp
  • T to C, chromosome 2 at 119,186,046 bp
  • A to G, chromosome 2 at 132,373,675 bp
  • T to A, chromosome 2 at 156,521,786 bp
  • T to C, chromosome 3 at 14,611,064 bp
  • C to T, chromosome 3 at 108,208,538 bp
  • T to C, chromosome 4 at 17,853,842 bp
  • A to C, chromosome 4 at 21,810,797 bp
  • T to C, chromosome 4 at 118,571,745 bp
  • C to T, chromosome 5 at 87,080,865 bp
  • A to T, chromosome 5 at 115,150,100 bp
  • A to G, chromosome 5 at 122,932,661 bp
  • A to G, chromosome 5 at 124,811,482 bp
  • A to C, chromosome 6 at 148,863,540 bp
  • T to A, chromosome 7 at 30,314,192 bp
  • T to A, chromosome 7 at 44,623,094 bp
  • C to G, chromosome 7 at 78,907,159 bp
  • T to C, chromosome 7 at 112,053,316 bp
  • T to C, chromosome 7 at 127,801,288 bp
  • A to G, chromosome 8 at 16,070,352 bp
  • C to T, chromosome 8 at 24,533,770 bp
  • C to T, chromosome 8 at 64,749,784 bp
  • T to C, chromosome 9 at 53,377,255 bp
  • T to C, chromosome 9 at 72,856,946 bp
  • A to G, chromosome 9 at 104,099,139 bp
  • T to A, chromosome 9 at 107,916,297 bp
  • T to C, chromosome 9 at 108,831,794 bp
  • T to C, chromosome 10 at 42,696,470 bp
  • A to G, chromosome 10 at 75,585,902 bp
  • T to C, chromosome 10 at 129,647,854 bp
  • A to G, chromosome 11 at 32,213,115 bp
  • A to G, chromosome 11 at 68,556,542 bp
  • A to G, chromosome 11 at 69,431,148 bp
  • C to T, chromosome 11 at 69,458,920 bp
  • A to G, chromosome 11 at 76,048,490 bp
  • T to C, chromosome 11 at 101,089,227 bp
  • A to C, chromosome 15 at 44,459,463 bp
  • T to A, chromosome 15 at 58,009,596 bp
  • G to A, chromosome 15 at 75,887,768 bp
  • T to C, chromosome 15 at 76,353,885 bp
  • T to G, chromosome 16 at 20,530,979 bp
  • G to A, chromosome 17 at 23,820,109 bp
  • A to G, chromosome 17 at 25,377,272 bp
  • T to C, chromosome 17 at 74,646,601 bp
  • A to C, chromosome 17 at 90,454,943 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043247-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.