Strain Name:
C57BL/6J-MtgxR6037Btlr/Mmmh
Stock Number:
043258-MU
Citation ID:
RRID:MMRRC_043258-MU
Other Names:
R6037 (G1), C57BL/6J-MtgxR6037Btlr
Major Collection:

Gene Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, nmf261, neuroaxonal dystrophy, ROSA62, SpbIV, 1700022P15Rik, 5830426A08Rik, Spnb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80297
Homologene: 11879
Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: Scare1, LOX-1, SR-EI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 3010002K18Rik, Qprs, 2410081F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Fry
Name: FRY microtubule binding protein
Synonyms: 9330186A19Rik, cg003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Nomo1
Name: nodal modulator 1
Synonyms: Nomo, D7Ertd156e, PM5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 211548
Homologene: 13810
Dcun1d3
Name: DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Synonyms: 1700020A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233805
Homologene: 16155
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, C030033M12Rik, 4832420A03Rik, XAP8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Abi2
Name: abl-interactor 2
Synonyms: 8430425M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329165
Homologene: 4209
Polr3f
Name: polymerase (RNA) III (DNA directed) polypeptide F
Synonyms: RPC6, 3110032A07Rik, 3010019O03Rik, RPC39, 2810411G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70408
Homologene: 4722
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, G630013P12Rik, TFIIIB90, TAF3B1, TFC5, Tfnr, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Klf12
Name: Kruppel-like factor 12
Synonyms: D530033K05Rik, AP-2rep, 2700063E05Rik, B130052C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16597
VEGA: 14
HGNC: HGNC:6346
Homologene: 21417
Wipf2
Name: WAS/WASL interacting protein family, member 2
Synonyms: 5730509C05Rik, 1110014J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68524
Homologene: 15777
Thrsp
Name: thyroid hormone responsive
Synonyms: S14, Spot 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21835
Homologene: 2441
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Hyls1
Name: HYLS1, centriolar and ciliogenesis associated
Synonyms: hydrolethalus syndrome 1, 3010015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76832
Homologene: 82283
Lifr
Name: LIF receptor alpha
Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Ano4
Name: anoctamin 4
Synonyms: Tmem16d, A330096O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320091
Homologene: 66599
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Fbn2
Name: fibrillin 2
Synonyms: sy, Fib-2, Sne
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, sj, muscle dysgenesis, fmd, mdg, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: V2r83, EG56544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56544
Homologene: 84832
Ece2
Name: endothelin converting enzyme 2
Synonyms: 6330509A19Rik, 1810009K13Rik, 9630025D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107522
Homologene: 56679
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: Oasl10, 2'-5' oligoadenylate synthetase-like 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210853
Homologene: 133253
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, Egfl4, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
St6galnac6
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Synonyms: ST6GalNAcVI, Siat7f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50935
Homologene: 8390
Cfap52
Name: cilia and flagella associated protein 52
Synonyms: 1700019F09Rik, Wdr16, 4933417B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71860
Homologene: 12416
Gm281
Name: predicted gene 281
Synonyms: LOC238939
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238939
Homologene: 141164
Mus81
Name: MUS81 structure-specific endonuclease subunit
Synonyms: 1200008A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71711
Homologene: 5725
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: Flt-4, VEGFR3, VEGFR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Olfr1066
Name: olfactory receptor 1066
Synonyms: GA_x6K02T2Q125-47925557-47924616, MOR256-52P, MOR188-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257880
Homologene: 79468
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75087
Homologene: 18988
Olfr1034
Name: olfactory receptor 1034
Synonyms: MOR227-8P, MOR245-14P, GA_x6K02T2Q125-47521463-47522395, MOR227-8P, Olfr1533-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258216
Homologene: 51741
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, D130016B08Rik, Zfx1b, Zfhx1b, SIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24136
Homologene: 8868
Art5
Name: ADP-ribosyltransferase 5
Synonyms: Yac-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11875
Homologene: 7231
Pih1d1
Name: PIH1 domain containing 1
Synonyms: 1110061L23Rik, 4933413A04Rik, Nop17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68845
Homologene: 9914
Olfr301
Name: olfactory receptor 301
Synonyms: Olfr1531-ps1, MOR221-1P, MOR221-4, GA_x6K02T2NHDJ-9693313-9692378, MOR221-1P, MOR211-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257958
Homologene: 128067
Olfr147
Name: olfactory receptor 147
Synonyms: M3, MOR164-1, GA_x6K02T2PVTD-32098059-32099003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258869
VEGA: 9
Homologene: 128279
Asgr1
Name: asialoglycoprotein receptor 1
Synonyms: Asgr, ASGPR1, Asgr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11889
HGNC: HGNC:742
Homologene: 1263
Gm10684
Name: predicted gene 10684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100038468
VEGA: 9
Vmn2r125
Name: vomeronasal 2, receptor 125
Synonyms: Gm20782
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 670059
VEGA: 4
Olfr936
Name: olfactory receptor 936
Synonyms: MOR171-37, EG628171, GA_x6K02T2PVTD-32743332-32742397
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100503486
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 60,464,579 bp
  • C to T, chromosome 1 at 136,070,967 bp
  • A to G, chromosome 1 at 185,396,109 bp
  • A to G, chromosome 2 at 32,612,228 bp
  • G to T, chromosome 2 at 44,988,640 bp
  • T to C, chromosome 2 at 86,046,584 bp
  • T to A, chromosome 2 at 86,455,789 bp
  • A to G, chromosome 2 at 144,536,023 bp
  • G to A, chromosome 2 at 180,207,013 bp
  • C to A, chromosome 3 at 64,081,729 bp
  • C to A, chromosome 4 at 156,351,101 bp
  • T to C, chromosome 5 at 120,649,501 bp
  • T to C, chromosome 5 at 120,769,319 bp
  • T to A, chromosome 5 at 150,428,179 bp
  • C to T, chromosome 6 at 67,478,954 bp
  • A to G, chromosome 6 at 129,493,541 bp
  • T to C, chromosome 7 at 25,364,406 bp
  • T to A, chromosome 7 at 27,364,170 bp
  • C to T, chromosome 7 at 45,156,314 bp
  • T to A, chromosome 7 at 46,062,999 bp
  • C to T, chromosome 7 at 86,413,270 bp
  • T to G, chromosome 7 at 97,417,292 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • C to A, chromosome 7 at 102,098,384 bp
  • A to G, chromosome 7 at 119,857,742 bp
  • A to C, chromosome 7 at 135,696,803 bp
  • G to A, chromosome 9 at 35,561,184 bp
  • T to A, chromosome 9 at 38,403,305 bp
  • A to G, chromosome 9 at 39,047,107 bp
  • T to A, chromosome 9 at 45,107,741 bp
  • A to G, chromosome 9 at 107,513,539 bp
  • A to G, chromosome 10 at 89,317,246 bp
  • C to T, chromosome 11 at 28,921,760 bp
  • C to T, chromosome 11 at 30,426,349 bp
  • G to A, chromosome 11 at 49,637,040 bp
  • C to T, chromosome 11 at 67,946,300 bp
  • T to A, chromosome 11 at 70,056,421 bp
  • C to T, chromosome 11 at 98,896,179 bp
  • G to A, chromosome 13 at 42,157,940 bp
  • A to T, chromosome 13 at 100,027,449 bp
  • T to C, chromosome 14 at 13,864,282 bp
  • T to C, chromosome 14 at 99,900,214 bp
  • A to G, chromosome 15 at 7,186,943 bp
  • A to C, chromosome 15 at 85,819,766 bp
  • A to G, chromosome 16 at 20,630,362 bp
  • A to G, chromosome 17 at 22,147,434 bp
  • T to C, chromosome 18 at 58,044,223 bp
  • T to C, chromosome 19 at 5,484,004 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6037 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043258-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.