Strain Name:
C57BL/6J-MtgxR5572Btlr/Mmmh
Stock Number:
043266-MU
Citation ID:
RRID:MMRRC_043266-MU
Other Names:
R5572 (G1)
Major Collection:

Gene Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74123
Homologene: 12536
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81897
Homologene: 68126
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21899
Homologene: 21223
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20981
Homologene: 9617
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, E6-AP ubiquitin protein ligase, A130086L21Rik, 5830462N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22215
Homologene: 7988
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70227
Homologene: 133818
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Ntm
Name: neurotrimin
Synonyms: 6230410L23Rik, B230210G24Rik, Hnt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235106
Homologene: 41139
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117146
Homologene: 13775
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Kirrel3
Name: kirre like nephrin family adhesion molecule 3
Synonyms: Neph2, 1500010O20Rik, 2900036G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67703
Homologene: 57050
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: Hif1b, ESTM42, D3Ertd557e, bHLHe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Ret
Name: ret proto-oncogene
Synonyms: RET51, RET9, c-Ret
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19713
HGNC: HGNC:9967
Homologene: 7517
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: Epac2, cAMP-GEFII, 1300003D15Rik, 5730402K07Rik, 6330581N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56508
Homologene: 4451
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
2610507B11Rik
Name: RIKEN cDNA 2610507B11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72503
Homologene: 34730
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49A, Ly49o129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16627
Homologene: 110821
Il1a
Name: interleukin 1 alpha
Synonyms: Il-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16175
HGNC: HGNC:5991
Homologene: 480
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57775
Homologene: 49641
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637896
Homologene: 115466
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Il6ra
Name: interleukin 6 receptor, alpha
Synonyms: IL-6 receptor alpha chain, CD126, Il6r, IL-6R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16194
HGNC: HGNC:6019
Homologene: 474
Abcd4
Name: ATP-binding cassette, sub-family D (ALD), member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72137
Homologene: 17609
Olfr652
Name: olfactory receptor 652
Synonyms: GA_x6K02T2PBJ9-7191524-7192471, MOR31-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259050
Homologene: 17477
Igsf11
Name: immunoglobulin superfamily, member 11
Synonyms: BT-IgSF, 1700025L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207683
Homologene: 17613
Rhbdd1
Name: rhomboid domain containing 1
Synonyms: 4930418P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76867
Homologene: 12659
Rasip1
Name: Ras interacting protein 1
Synonyms: 2610025P08Rik, Rain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69903
Homologene: 9847
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: BPAg2, BP180, Bpag, Bpag2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63913
Homologene: 62170
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229927
Homologene: 135610
Nnmt
Name: nicotinamide N-methyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18113
HGNC: HGNC:7861
Homologene: 4496
Apol10a
Name: apolipoprotein L 10A
Synonyms: 9030421J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 245282
Homologene: 129975
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231396
Homologene: 128251
Zbtb8b
Name: zinc finger and BTB domain containing 8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 215627
Homologene: 65127
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242894
Homologene: 4180
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 117066
VEGA: 13
Egfl7
Name: EGF-like domain 7
Synonyms: Zneu1, VE-statin, vascular endothelial-statin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353156
Homologene: 9427
Olfr318
Name: olfactory receptor 318
Synonyms: GA_x6K02T2NKPP-692816-693736, MOR285-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258494
Homologene: 133825
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50702
HGNC: HGNC:4888
Homologene: 55632
N4bp2l2
Name: NEDD4 binding protein 2-like 2
Synonyms: 2700092H06Rik, zag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381695
Homologene: 115380
C1qc
Name: complement component 1, q subcomponent, C chain
Synonyms: C1qg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12262
HGNC: HGNC:1245
Homologene: 32020
Pomk
Name: protein-O-mannose kinase
Synonyms: Sgk196, 4930444A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74653
Homologene: 12580
Eif2s3y
Name: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
Synonyms: Tfy, Eif-2gy, Spy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 26908
Homologene: 99414
Gm15121
Name: predicted gene 15121
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
C1rb
Name: complement component 1, r subcomponent B
Synonyms: mC1rB, Gm8551
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667277
HGNC: HGNC:1246
Homologene: 1313
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 82,340,810 bp
  • A to C, chromosome 1 at 97,854,744 bp
  • A to G, chromosome 1 at 139,556,427 bp
  • T to C, chromosome 1 at 151,709,190 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • T to C, chromosome 2 at 26,591,691 bp
  • A to T, chromosome 2 at 31,414,525 bp
  • G to A, chromosome 2 at 31,414,526 bp
  • A to G, chromosome 2 at 59,862,707 bp
  • G to A, chromosome 2 at 72,034,120 bp
  • A to T, chromosome 2 at 76,853,628 bp
  • A to G, chromosome 2 at 129,307,918 bp
  • A to T, chromosome 3 at 89,871,282 bp
  • G to T, chromosome 3 at 95,474,704 bp
  • T to C, chromosome 3 at 144,827,309 bp
  • T to C, chromosome 4 at 129,428,541 bp
  • T to C, chromosome 4 at 136,892,462 bp
  • C to T, chromosome 5 at 8,715,108 bp
  • T to A, chromosome 5 at 25,809,888 bp
  • A to T, chromosome 5 at 64,955,018 bp
  • A to G, chromosome 5 at 87,089,482 bp
  • G to A, chromosome 5 at 114,406,179 bp
  • C to T, chromosome 5 at 137,394,431 bp
  • G to A, chromosome 5 at 150,662,290 bp
  • T to C, chromosome 6 at 118,155,431 bp
  • T to C, chromosome 6 at 120,412,375 bp
  • T to C, chromosome 6 at 124,580,799 bp
  • T to A, chromosome 6 at 130,372,839 bp
  • A to G, chromosome 7 at 6,962,192 bp
  • A to T, chromosome 7 at 39,535,239 bp
  • A to G, chromosome 7 at 44,390,718 bp
  • G to T, chromosome 7 at 45,636,729 bp
  • T to C, chromosome 7 at 59,288,777 bp
  • A to G, chromosome 7 at 86,915,512 bp
  • A to C, chromosome 7 at 103,460,698 bp
  • A to T, chromosome 7 at 104,564,994 bp
  • T to A, chromosome 8 at 25,983,190 bp
  • A to G, chromosome 9 at 29,014,216 bp
  • G to A, chromosome 9 at 35,000,948 bp
  • G to T, chromosome 9 at 44,500,798 bp
  • A to G, chromosome 9 at 48,592,147 bp
  • T to C, chromosome 9 at 106,225,637 bp
  • A to G, chromosome 11 at 58,720,229 bp
  • A to T, chromosome 11 at 78,264,567 bp
  • T to G, chromosome 12 at 35,103,120 bp
  • T to C, chromosome 12 at 84,606,276 bp
  • T to A, chromosome 13 at 61,564,968 bp
  • T to C, chromosome 15 at 77,488,634 bp
  • T to C, chromosome 15 at 78,442,422 bp
  • C to T, chromosome 16 at 39,024,932 bp
  • T to G, chromosome 16 at 44,481,305 bp
  • T to A, chromosome 17 at 25,251,475 bp
  • A to G, chromosome 17 at 47,880,879 bp
  • A to G, chromosome 17 at 57,224,673 bp
  • A to T, chromosome 18 at 37,991,066 bp
  • A to T, chromosome 19 at 47,650,729 bp
  • G to A, chromosome Y at 1,016,631 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5572 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043266-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.