Strain Name:
C57BL/6J-MtgxR5613Btlr
Stock Number:
043274-MU
Citation ID:
RRID:MMRRC_043274-MU
Other Names:
R5613 (G1)
Major Collection:

Gene Information

Dnm2
Name: dynamin 2
Synonyms: b2b2159Clo, Dyn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Mapt
Name: microtubule-associated protein tau
Synonyms: Tau, Mtapt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Srfbp1
Name: serum response factor binding protein 1
Synonyms: 2810036K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67222
VEGA: 18
Homologene: 12101
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnchc1, Dnec1, MAP1C, dynein heavy chain, retrograde transport, Swl, Loa, 9930018I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Tlr4
Name: toll-like receptor 4
Synonyms: Lps, Rasl2-8, lipopolysaccharide response
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21898
Homologene: 41317
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 6330512O03Rik, 2310038O07Rik, D10Ertd516e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71902
Homologene: 10202
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240064
Homologene: 107106
Nefm
Name: neurofilament, medium polypeptide
Synonyms: NF165, neurofilament-M, Nfm, NF160, NF-M, Nef3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18040
HGNC: HGNC:7734
Homologene: 137211
Ppp1r11
Name: protein phosphatase 1, regulatory inhibitor subunit 11
Synonyms: Tctex5, Tctex-5, HCG-V, HCGV, Tcte5, 1500041B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76497
HGNC: HGNC:9285
Homologene: 32520
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Susd6
Name: sushi domain containing 6
Synonyms: 4933426M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217684
VEGA: 12
Homologene: 40980
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208263
Homologene: 9208
Haus3
Name: HAUS augmin-like complex, subunit 3
Synonyms: D5H4S43, D5H4S43E, D4S43h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231123
Homologene: 75209
Ptger2
Name: prostaglandin E receptor 2 (subtype EP2)
Synonyms: EP2 receptor, EP2, Ptgerep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19217
HGNC: HGNC:9594
Homologene: 739
Klf7
Name: Kruppel-like factor 7 (ubiquitous)
Synonyms: 9830124P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93691
HGNC: HGNC:6350
Homologene: 2751
Ttn
Name: titin
Synonyms: shru, L56, mdm, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, D330041I19Rik, D830007G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Creb3
Name: cAMP responsive element binding protein 3
Synonyms: LZIP-1, LZIP, LZIP-2, Luman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12913
HGNC: HGNC:2347
Homologene: 31375
Gm5901
Name: predicted gene 5901
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100503879
Homologene: 18311
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381693
Homologene: 124480
Eral1
Name: Era (G-protein)-like 1 (E. coli)
Synonyms: 9130407C09Rik, 2610524P08Rik, MERA-S, MERA-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213121
Homologene: 16977
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Schnurri-2, Gm20114, Shn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Gm5600
Name: predicted gene 5600
Synonyms: ENSMUSG00000073862
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108167501
Olfr1251
Name: olfactory receptor 1251
Synonyms: MOR231-15P, GA_x6K02T2Q125-51109312-51108356, MOR231-24_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259145
Homologene: 74065
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, melastatin, 4732499L03Rik, LTRPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Slc16a12
Name: solute carrier family 16 (monocarboxylic acid transporters), member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240638
Homologene: 130007
Prss52
Name: protease, serine 52
Synonyms: 1700049K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73382
Homologene: 105740
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 668758
Homologene: 110776
Dclk1
Name: doublecortin-like kinase 1
Synonyms: DCLK, Dcl, 2810480F11Rik, Dcamkl1, 1700113D08Rik, CPG16, Click-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Arhgef5
Name: Rho guanine nucleotide exchange factor (GEF) 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54324
Homologene: 66300
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: Camkg, CaMK II, Ca2+/calmodulin-dependent protein kinase II, 5930429P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt1, Trim30, Rpt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20128
Homologene: 114426
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Pkn1
Name: protein kinase N1
Synonyms: Stk3, Prkcl1, PRK1, PAK1, F730027O18Rik, Pkn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: AT1B, Agtr-1b, Angtr-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Tnfsf18
Name: tumor necrosis factor (ligand) superfamily, member 18
Synonyms: GITR ligand, Gitrl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240873
Homologene: 3732
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270210
VEGA: 9
Homologene: 136302
Olfr155
Name: olfactory receptor 155
Synonyms: OR37A, mOR37a, Olfr37a, GA_x6K02T2N78B-16092200-16091241, MOR262-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29845
HGNC: HGNC:8276
Homologene: 84331
9430097D07Rik
Name: RIKEN cDNA 9430097D07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319245
VEGA: 2
Dus3l
Name: dihydrouridine synthase 3-like (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224907
VEGA: 17
Homologene: 6533
Mypop
Name: Myb-related transcription factor, partner of profilin
Synonyms: Myodysa, P42pop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232934
Homologene: 17083
Rfpl4b
Name: ret finger protein-like 4B
Synonyms: Gm62, LOC215919, Gm3037
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215919
Homologene: 130122
Rep15
Name: RAB15 effector protein
Synonyms: 2210417D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66532
Homologene: 11985
Tnfsf13
Name: tumor necrosis factor (ligand) superfamily, member 13
Synonyms: TALL2, 2310026N09Rik, TRDL1, APRIL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69583
Homologene: 56971
Spdye4c
Name: speedy/RINGO cell cycle regulator family, member E4C
Synonyms: Gm355, LOC241634
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241634
Homologene: 78093
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Ity, Nramp1, host resistance locus Bcg/Ity/Lsh, ity, Ity1, Lsh, Bcg, Nramp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18173
Homologene: 73884
Trav10
Name: T cell receptor alpha variable 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 667765
Tssk1
Name: testis-specific serine kinase 1
Synonyms: Tsk1, Tssk, TSK-1, Stk22a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22114
Homologene: 56448
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 14,302,929 bp
  • G to A, chromosome 1 at 64,042,396 bp
  • G to A, chromosome 1 at 74,380,906 bp
  • T to C, chromosome 1 at 156,033,753 bp
  • A to G, chromosome 1 at 161,503,728 bp
  • T to C, chromosome 2 at 32,575,334 bp
  • A to T, chromosome 2 at 76,909,652 bp
  • T to C, chromosome 2 at 89,667,044 bp
  • A to T, chromosome 2 at 128,592,969 bp
  • CAAA to CAA, chromosome 2 at 152,973,601 bp
  • T to C, chromosome 3 at 20,316,260 bp
  • A to G, chromosome 3 at 55,516,939 bp
  • A to G, chromosome 3 at 96,683,018 bp
  • A to T, chromosome 4 at 6,272,799 bp
  • T to C, chromosome 4 at 43,566,196 bp
  • G to A, chromosome 4 at 43,854,528 bp
  • T to A, chromosome 4 at 66,840,885 bp
  • A to G, chromosome 5 at 34,167,829 bp
  • A to T, chromosome 5 at 149,584,470 bp
  • A to G, chromosome 6 at 43,274,063 bp
  • G to A, chromosome 6 at 48,455,044 bp
  • A to C, chromosome 6 at 125,120,546 bp
  • G to T, chromosome 6 at 147,032,854 bp
  • G to A, chromosome 7 at 18,991,976 bp
  • A to T, chromosome 7 at 28,142,878 bp
  • A to G, chromosome 7 at 64,208,411 bp
  • T to A, chromosome 7 at 104,430,182 bp
  • A to G, chromosome 7 at 105,377,325 bp
  • A to G, chromosome 7 at 113,708,056 bp
  • C to T, chromosome 8 at 83,677,761 bp
  • T to A, chromosome 9 at 21,472,667 bp
  • T to A, chromosome 9 at 109,338,533 bp
  • T to A, chromosome 9 at 121,767,519 bp
  • T to C, chromosome 10 at 14,139,495 bp
  • T to A, chromosome 10 at 38,821,377 bp
  • A to T, chromosome 10 at 119,215,323 bp
  • G to T, chromosome 11 at 69,683,995 bp
  • G to A, chromosome 11 at 78,074,404 bp
  • A to G, chromosome 11 at 104,302,390 bp
  • G to T, chromosome 12 at 80,868,534 bp
  • T to C, chromosome 12 at 110,632,820 bp
  • A to C, chromosome 13 at 46,687,271 bp
  • A to C, chromosome 13 at 70,730,134 bp
  • T to C, chromosome 14 at 20,737,491 bp
  • T to G, chromosome 14 at 44,989,503 bp
  • A to T, chromosome 14 at 53,506,026 bp
  • A to T, chromosome 14 at 64,109,502 bp
  • T to A, chromosome 14 at 68,121,134 bp
  • T to C, chromosome 16 at 17,894,500 bp
  • A to T, chromosome 17 at 23,345,333 bp
  • T to C, chromosome 17 at 32,819,990 bp
  • C to A, chromosome 17 at 36,951,488 bp
  • T to C, chromosome 17 at 46,503,844 bp
  • T to C, chromosome 17 at 56,767,882 bp
  • G to A, chromosome 18 at 52,483,645 bp
  • A to T, chromosome 19 at 12,485,403 bp
  • T to C, chromosome 19 at 34,674,958 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5613 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043274-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.