Strain Name:
C57BL/6J-MtgxR5618Btlr/Mmmh
Stock Number:
043277-MU
Citation ID:
RRID:MMRRC_043277-MU
Other Names:
R5618 (G1)
Major Collection:

Strain Information

Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74244
Homologene: 4662
Sema7a
Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Synonyms: Semaphorin K1, CDw108, Semal, 2900057C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20361
VEGA: 9
Homologene: 2678
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81897
Homologene: 68126
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: Riz, Riz1, LOC381568, E330024L24Rik, 4833427P12Rik, KMT8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Exog
Name: endo/exonuclease (5'-3'), endonuclease G-like
Synonyms: ENGL-a, ENDOGL2, ENGL-B, Endogl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208194
VEGA: 9
HGNC: HGNC:3347
Homologene: 3745
Vmp1
Name: vacuole membrane protein 1
Synonyms: 4930579A11Rik, 3110098I04Rik, Tmem49, Tango5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75909
Homologene: 23686
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16561
Homologene: 99835
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: SFA66, PRP11, Sap62, 66kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20222
Homologene: 133823
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74355
Homologene: 23665
Wapl
Name: WAPL cohesin release factor
Synonyms: A530089A20Rik, Wapal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218914
Homologene: 41002
Tmem87a
Name: transmembrane protein 87A
Synonyms: A930025J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211499
Homologene: 9165
Bcl7a
Name: B cell CLL/lymphoma 7A
Synonyms: 4432415N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77045
HGNC: HGNC:1004
Homologene: 10869
Fam222b
Name: family with sequence similarity 222, member B
Synonyms: BC017647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216971
Homologene: 10054
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
Pard6a
Name: par-6 family cell polarity regulator alpha
Synonyms: Par6c, PAR6alpha, TAX40, Tip-40, 0710008C04Rik, 2610010A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56513
Homologene: 9661
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, Astrin, s17, S17, Mastrin, Deepest, D11Bhm180e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54141
Homologene: 4718
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: VIa, sema, Sema6A-1, Semaq, A730020P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: DNA ligase IV, 5830471N16Rik, tiny
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Gnb4
Name: guanine nucleotide binding protein (G protein), beta 4
Synonyms: 6720453A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14696
Homologene: 69140
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Fbl
Name: fibrillarin
Synonyms: RNU3IP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14113
HGNC: HGNC:3599
Homologene: 1099
Cct5
Name: chaperonin containing Tcp1, subunit 5 (epsilon)
Synonyms: Ccte, TCPE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12465
HGNC: HGNC:1618
Homologene: 6287
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243963
Homologene: 18698
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11567
Homologene: 38200
Pmpcb
Name: peptidase (mitochondrial processing) beta
Synonyms: MPPP52, MPP11, 3110004O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73078
HGNC: HGNC:9119
Homologene: 3160
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Uqcc4
Name: ubiquinol-cytochrome c reductase complex assembly factor 4
Synonyms: BC003965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214489
VEGA: 17
Homologene: 52829
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71310
Homologene: 57079
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624765
Homologene: 83483
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Csgalnact2
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 2
Synonyms: 4632415D10Rik, Galnact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78752
Homologene: 23109
Defb12
Name: defensin beta 12
Synonyms: 9230103N16Rik, mBD-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77674
Homologene: 17531
Serpinf1
Name: serine (or cysteine) peptidase inhibitor, clade F, member 1
Synonyms: EPC-1, Pedf, Sdf3, pigment epithelium derived factor, Pedfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20317
HGNC: HGNC:8824
Homologene: 1965
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625131
Homologene: 129606
Or8b44
Name: olfactory receptor family 8 subfamily B member 44
Synonyms: GA_x6K02T2PVTD-32204729-32205661, MOR165-5, Olfr907
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258801
VEGA: 9
Homologene: 27268
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, polaris, Oak Ridge polycystic kidneys, orpk, IFT88, fxo, TgN737Rpw, Tg737Rpw, Ttc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC-76, UNC76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Tmprss11d
Name: transmembrane protease, serine 11d
Synonyms: AsP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231382
Homologene: 74519
Or6ae1
Name: olfactory receptor family 6 subfamily AE member 1
Synonyms: GA_x6K02T2PBJ9-42315125-42314187, MOR103-5, Olfr522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258954
Homologene: 62435
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
1700028K03Rik
Name: RIKEN cDNA 1700028K03 gene
Synonyms: SCRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76421
Homologene: 18810
Dipk1b
Name: divergent protein kinase domain 1B
Synonyms: PIP49, B230317C12Rik, Fam69b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56279
Homologene: 10516
Mlc1
Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
Synonyms: Kiaa0027-hp, WKL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170790
Homologene: 15775
H2-Q4
Name: histocompatibility 2, Q region locus 4
Synonyms: Qb-1, Qat-4, Qb1, Qa4, Qa-4, H-2Q4, H2-Gs10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15015
Homologene: 128352
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: 4932411G14Rik, Fam75d1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238663
Homologene: 129932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 26,634,875 bp
  • C to T, chromosome 2 at 58,462,943 bp
  • C to A, chromosome 2 at 120,369,306 bp
  • A to T, chromosome 2 at 155,437,897 bp
  • C to T, chromosome 3 at 32,591,207 bp
  • C to T, chromosome 3 at 145,004,977 bp
  • A to C, chromosome 4 at 58,070,537 bp
  • C to T, chromosome 4 at 143,133,537 bp
  • A to T, chromosome 4 at 143,850,693 bp
  • A to T, chromosome 4 at 149,269,889 bp
  • A to G, chromosome 5 at 21,742,788 bp
  • A to T, chromosome 5 at 43,729,907 bp
  • A to T, chromosome 5 at 86,306,295 bp
  • G to A, chromosome 5 at 107,548,199 bp
  • A to T, chromosome 5 at 123,361,202 bp
  • A to G, chromosome 6 at 84,106,824 bp
  • A to G, chromosome 6 at 114,673,699 bp
  • A to T, chromosome 6 at 118,126,316 bp
  • A to G, chromosome 7 at 28,178,986 bp
  • T to A, chromosome 7 at 44,741,732 bp
  • A to G, chromosome 7 at 140,162,272 bp
  • A to T, chromosome 8 at 9,972,021 bp
  • A to T, chromosome 8 at 19,114,798 bp
  • A to G, chromosome 8 at 83,242,592 bp
  • T to C, chromosome 8 at 105,702,914 bp
  • A to T, chromosome 9 at 36,843,932 bp
  • C to T, chromosome 9 at 38,498,740 bp
  • A to T, chromosome 9 at 39,590,704 bp
  • A to T, chromosome 9 at 57,960,283 bp
  • A to T, chromosome 9 at 106,224,739 bp
  • G to T, chromosome 9 at 119,462,751 bp
  • T to C, chromosome 10 at 79,148,921 bp
  • T to C, chromosome 10 at 80,804,576 bp
  • T to C, chromosome 10 at 127,010,577 bp
  • A to T, chromosome 10 at 130,479,948 bp
  • T to A, chromosome 11 at 75,410,184 bp
  • T to G, chromosome 11 at 78,154,240 bp
  • T to G, chromosome 11 at 78,304,080 bp
  • C to T, chromosome 11 at 86,663,562 bp
  • G to A, chromosome 13 at 59,726,400 bp
  • T to A, chromosome 13 at 76,173,426 bp
  • T to A, chromosome 14 at 34,691,906 bp
  • T to C, chromosome 14 at 57,481,508 bp
  • A to G, chromosome 15 at 31,598,015 bp
  • C to A, chromosome 15 at 88,974,566 bp
  • A to G, chromosome 16 at 15,809,612 bp
  • A to G, chromosome 16 at 32,754,253 bp
  • A to G, chromosome 16 at 52,152,668 bp
  • G to A, chromosome 17 at 25,184,989 bp
  • T to A, chromosome 17 at 35,379,925 bp
  • A to T, chromosome 17 at 71,455,727 bp
  • A to T, chromosome 18 at 47,281,948 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5618 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043277-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.