Strain Name:
C57BL/6J-MtgxR5663Btlr
Stock Number:
043306-MU
Citation ID:
RRID:MMRRC_043306-MU
Other Names:
R5663 (G1)
Major Collection:

Gene Information

Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGFbeta1, TGF-beta 1, Tgfb-1, Tgfb, TGF-beta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 21803
Homologene: 540
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: Rptpbeta, PTPbeta, Ptpz, PTPzeta, Ptprz, RPTPz, phosphacan, DSD-1-PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: FATP4, fatty acid transport protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26569
Homologene: 68437
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: 2010009J12Rik, 2210016I17Rik, D1Ertd202e, Plu1, PLU-1, Rb-Bp2, Jarid1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 75605
Homologene: 48448
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76804
Homologene: 41004
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Cdh1, Fyr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56371
Homologene: 9444
Smyd1
Name: SET and MYND domain containing 1
Synonyms: Bop, 4632404M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12180
Homologene: 7645
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF-kappaB p50, p50/p105, NF-kappaB, p50, NF kappaB1, p50 subunit of NF kappaB, nuclear factor kappaB p50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 117599
Homologene: 50463
Kif15
Name: kinesin family member 15
Synonyms: 3930402I10Rik, Knsl7, 3110023M17Rik, N-10 kinesin, HKLP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 209737
VEGA: 9
Homologene: 23210
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 5830411K19Rik, 4933425I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 71148
Homologene: 136176
Agfg1
Name: ArfGAP with FG repeats 1
Synonyms: C130049H11Rik, Hrb, Rip, D730048C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15463
HGNC: HGNC:5175
Homologene: 37929
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, PipkIII, 5230400C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12032
Homologene: 7244
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: 1810009A16Rik, Zubr1, A930005E13Rik, D930005K06Rik, LOC381562, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69116
Homologene: 10804
5330417C22Rik
Name: RIKEN cDNA 5330417C22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229722
Homologene: 23249
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70693
Homologene: 19235
Nelfb
Name: negative elongation factor complex member B
Synonyms: A730008L03Rik, Cobra1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 58202
Homologene: 121600
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216831
Homologene: 65284
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: MINOR, NOR-1, TEC, Nor1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Fam160a1
Name: family with sequence similarity 160, member A1
Synonyms: 9930021J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229488
Homologene: 85149
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20679
Homologene: 22631
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a, C79217, Cav1.3alpha1, D-LTCC, Cacnl1a2, Cchl1a2, 8430418G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
1700016K19Rik
Name: RIKEN cDNA 1700016K19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74230
Homologene: 52371
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: D030026M03Rik, Fir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227377
Homologene: 8877
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380730
Homologene: 134511
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231646
Homologene: 82639
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: B930011P16Rik, In(5)6H-p, Rw, Peplb, LOC384168, Dpp-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, caPI3K, 6330412C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Ndufb5
Name: NADH:ubiquinone oxidoreductase subunit B5
Synonyms: 0610007D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 66046
HGNC: HGNC:7700
Homologene: 31093
Whrn
Name: whirlin
Synonyms: wi, Dfnb31, C430046P22Rik, 1110035G07Rik, Ush2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73750
Homologene: 18739
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: NHE-3, 9030624O13Rik, NHE3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105243
VEGA: 13
Homologene: 55804
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244650
Homologene: 71015
Masp1
Name: mannan-binding lectin serine peptidase 1
Synonyms: Crarf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Olfr1508
Name: olfactory receptor 1508
Synonyms: GA_x6K02T2RJGY-520647-521579, MOR244-4, MOR10, MOR244-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 57270
HGNC: HGNC:8296
Homologene: 10737
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, entactin-1, nidogen-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Xrra1
Name: X-ray radiation resistance associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 446101
Homologene: 19547
Ccn5
Name: cellular communication network factor 5
Synonyms: rCop1, Wisp2, Crgr4, CCN5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22403
Homologene: 2882
1700021F07Rik
Name: RIKEN cDNA 1700021F07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 72221
Homologene: 82371
Edil3
Name: EGF-like repeats and discoidin I-like domains 3
Synonyms: Del1, developmental endothelial locus-1, Del-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13612
HGNC: HGNC:3173
Homologene: 21166
H2-Eb2
Name: histocompatibility 2, class II antigen E beta2
Synonyms: A130038H09Rik, Ia5, H-2Eb2, Ia-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381091
Homologene: 128636
Olfr695
Name: olfactory receptor 695
Synonyms: MOR283-6, GA_x6K02T2PBJ9-9092181-9091234
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258591
Homologene: 133597
Olfr523
Name: olfactory receptor 523
Synonyms: MOR104-4, GA_x6K02T2PBJ9-42327937-42328872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258511
Homologene: 27191
Paqr5
Name: progestin and adipoQ receptor family member V
Synonyms: 0610010I15Rik, mPRg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74090
Homologene: 9788
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 54667
Homologene: 23226
Zfp94
Name: zinc finger protein 94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22756
Homologene: 86846
Tas2r121
Name: taste receptor, type 2, member 121
Synonyms: Tas2r21, T2R21, mT2r48, mGR21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387349
Homologene: 41542
Rassf7
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms: 2400009B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66985
HGNC: HGNC:1166
Homologene: 2595
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100101919
Homologene: 41287
Mroh6
Name: maestro heat-like repeat family member 6
Synonyms: Gm19570
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223645
Homologene: 90414
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,531,557 bp
  • C to A, chromosome 1 at 46,535,148 bp
  • T to C, chromosome 1 at 65,216,028 bp
  • T to A, chromosome 1 at 82,893,452 bp
  • T to C, chromosome 1 at 93,570,013 bp
  • T to C, chromosome 1 at 134,630,635 bp
  • T to A, chromosome 2 at 25,203,489 bp
  • T to A, chromosome 2 at 29,812,370 bp
  • G to A, chromosome 2 at 163,825,253 bp
  • C to T, chromosome 2 at 173,527,897 bp
  • C to T, chromosome 3 at 32,462,779 bp
  • T to C, chromosome 3 at 32,747,749 bp
  • T to C, chromosome 3 at 85,672,433 bp
  • G to A, chromosome 3 at 87,995,613 bp
  • T to C, chromosome 3 at 89,941,794 bp
  • T to C, chromosome 3 at 108,492,083 bp
  • T to G, chromosome 3 at 135,603,851 bp
  • G to T, chromosome 4 at 48,055,931 bp
  • T to A, chromosome 4 at 63,418,448 bp
  • T to C, chromosome 4 at 74,399,348 bp
  • T to A, chromosome 4 at 103,150,542 bp
  • T to C, chromosome 4 at 139,428,583 bp
  • A to G, chromosome 5 at 27,049,622 bp
  • T to C, chromosome 5 at 49,999,285 bp
  • A to T, chromosome 5 at 114,334,094 bp
  • A to G, chromosome 6 at 23,035,143 bp
  • A to G, chromosome 6 at 71,239,721 bp
  • G to A, chromosome 6 at 132,700,557 bp
  • G to A, chromosome 7 at 24,302,827 bp
  • C to T, chromosome 7 at 25,694,281 bp
  • T to A, chromosome 7 at 99,886,043 bp
  • T to A, chromosome 7 at 106,873,670 bp
  • T to A, chromosome 7 at 115,550,054 bp
  • G to A, chromosome 7 at 140,176,321 bp
  • C to T, chromosome 7 at 141,217,090 bp
  • G to A, chromosome 8 at 109,904,344 bp
  • A to G, chromosome 9 at 61,968,862 bp
  • T to A, chromosome 9 at 122,991,851 bp
  • A to G, chromosome 10 at 81,370,526 bp
  • A to G, chromosome 10 at 120,105,793 bp
  • A to T, chromosome 11 at 65,024,291 bp
  • A to G, chromosome 11 at 76,000,221 bp
  • A to G, chromosome 11 at 103,613,123 bp
  • G to A, chromosome 13 at 13,472,834 bp
  • A to C, chromosome 13 at 74,163,712 bp
  • A to G, chromosome 13 at 89,042,508 bp
  • A to G, chromosome 14 at 30,123,340 bp
  • A to T, chromosome 14 at 52,463,595 bp
  • A to G, chromosome 15 at 75,888,588 bp
  • T to C, chromosome 16 at 23,452,938 bp
  • T to C, chromosome 17 at 34,333,408 bp
  • A to G, chromosome 19 at 27,793,617 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5663 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043306-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.