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Strain Name:
C57BL/6J-MtgxR5669Btlr/Mmmh
Stock Number:
043312-MU
Citation ID:
RRID:MMRRC_043312-MU
Other Names:
R5669 (G1)
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Foxa3
Name: forkhead box A3
Synonyms: Tcf-3g, Hnf3g, Hnf-3g, Tcf3g
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15377
HGNC: HGNC:5023
Homologene: 3308
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,924,968 bp
  • A to T, chromosome 1 at 78,497,913 bp
  • A to G, chromosome 1 at 90,953,120 bp
  • T to C, chromosome 2 at 41,111,038 bp
  • T to C, chromosome 2 at 87,252,441 bp
  • A to G, chromosome 2 at 119,903,426 bp
  • G to T, chromosome 2 at 127,347,279 bp
  • G to A, chromosome 2 at 136,116,284 bp
  • A to G, chromosome 2 at 150,192,178 bp
  • C to T, chromosome 3 at 96,808,898 bp
  • T to A, chromosome 3 at 100,951,117 bp
  • T to A, chromosome 4 at 123,476,225 bp
  • T to C, chromosome 4 at 144,395,843 bp
  • T to A, chromosome 5 at 4,050,540 bp
  • A to G, chromosome 5 at 30,622,349 bp
  • A to G, chromosome 5 at 44,012,943 bp
  • A to G, chromosome 5 at 125,300,387 bp
  • A to T, chromosome 6 at 25,669,352 bp
  • A to G, chromosome 6 at 69,631,848 bp
  • A to G, chromosome 6 at 72,606,010 bp
  • T to C, chromosome 6 at 118,184,243 bp
  • T to A, chromosome 7 at 5,675,737 bp
  • T to C, chromosome 7 at 19,014,251 bp
  • A to C, chromosome 7 at 19,373,022 bp
  • T to C, chromosome 7 at 35,040,674 bp
  • G to T, chromosome 7 at 79,117,496 bp
  • C to T, chromosome 7 at 109,825,439 bp
  • A to G, chromosome 7 at 114,237,585 bp
  • C to T, chromosome 7 at 143,807,431 bp
  • T to C, chromosome 9 at 19,783,757 bp
  • C to T, chromosome 9 at 58,247,063 bp
  • A to G, chromosome 9 at 105,925,998 bp
  • A to T, chromosome 9 at 109,145,510 bp
  • T to A, chromosome 10 at 45,316,433 bp
  • C to A, chromosome 10 at 121,804,850 bp
  • T to C, chromosome 11 at 35,797,584 bp
  • T to A, chromosome 11 at 75,504,738 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • A to T, chromosome 11 at 106,241,819 bp
  • T to C, chromosome 11 at 119,458,785 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to C, chromosome 12 at 85,147,867 bp
  • T to C, chromosome 12 at 109,460,038 bp
  • C to T, chromosome 12 at 111,302,013 bp
  • T to A, chromosome 12 at 119,190,628 bp
  • A to G, chromosome 13 at 32,845,316 bp
  • T to A, chromosome 13 at 75,130,102 bp
  • C to T, chromosome 14 at 55,596,704 bp
  • A to G, chromosome 14 at 111,681,623 bp
  • T to C, chromosome 15 at 45,114,252 bp
  • A to C, chromosome 15 at 76,614,163 bp
  • A to T, chromosome 15 at 78,454,956 bp
  • T to A, chromosome 16 at 4,768,815 bp
  • T to C, chromosome 19 at 20,610,920 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5669 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043312-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.