Strain Name:
C57BL/6J-MtgxR5687Btlr
Stock Number:
043320-MU
Citation ID:
RRID:MMRRC_043320-MU
Other Names:
R5687 (G1)
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223838
Homologene: 11808
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269473
Homologene: 8882
Nsmf
Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Synonyms: Jacob, Nelf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56876
Homologene: 10648
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224273
Homologene: 28544
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20116
Homologene: 133143
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270685
Homologene: 56706
Fam169a
Name: family with sequence similarity 169, member A
Synonyms: B230112C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320557
VEGA: 13
Homologene: 52656
Psmd3
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms: AntP91a, Psd3, Tstap91a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22123
HGNC: HGNC:9560
Homologene: 2102
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, Trap150, B230333E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230753
Homologene: 31289
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67302
VEGA: 14
Cct8
Name: chaperonin containing Tcp1, subunit 8 (theta)
Synonyms: Cctq, Tcpq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12469
HGNC: HGNC:1623
Homologene: 4802
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20924
Homologene: 2384
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Nasp
Name: nuclear autoantigenic sperm protein (histone-binding)
Synonyms: Epcs32, 5033430J04Rik, D4Ertd767e, Nasp-T
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50927
HGNC: HGNC:7644
Homologene: 133894
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: 2700050F09Rik, A430027N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72587
Homologene: 6372
Pard6b
Name: par-6 family cell polarity regulator beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58220
Homologene: 23302
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Dmp1
Name: dentin matrix protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13406
HGNC: HGNC:2932
Homologene: 68396
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72946
Homologene: 10795
Yeats4
Name: YEATS domain containing 4
Synonyms: NuBI-1, 4930573H17Rik, GAS41, B230215M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64050
VEGA: 10
Homologene: 4760
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230866
Homologene: 9002
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: PAF65A, C530024J06Rik, 2810417N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225895
Homologene: 4728
Sfrp2
Name: secreted frizzled-related protein 2
Synonyms: Sdf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20319
Homologene: 56438
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 1700020N17Rik, 5730402G09Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: 4933436G17Rik, 1700111L17Rik, 1700024G08Rik, Smaug, sunk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74480
Homologene: 19167
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Gm10800
Name: predicted gene 10800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Prph2
Name: peripherin 2
Synonyms: rds, Tspan22, Rd2, Nmf193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19133
HGNC: HGNC:9942
Homologene: 273
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Gcc1
Name: golgi coiled coil 1
Synonyms: 4932417P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74375
Homologene: 11567
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Olfr1285
Name: olfactory receptor 1285
Synonyms: GA_x6K02T2Q125-72459956-72460837, MOR248-25_p, MOR248-17P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545447
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 9430041O17Rik, 2010203O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234214
Homologene: 83295
Pdk2
Name: pyruvate dehydrogenase kinase, isoenzyme 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18604
HGNC: HGNC:8810
Homologene: 68265
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Gmpr
Name: guanosine monophosphate reductase
Synonyms: 2310004P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66355
HGNC: HGNC:4376
Homologene: 5009
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: stage specific embryonic cDNA-8, SSEC-8, Maid, DIP1, GCIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Slc6a13
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Synonyms: Gabt3, Gat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14412
Homologene: 9592
Parl
Name: presenilin associated, rhomboid-like
Synonyms: PSENIP2, PRO2207, PSARL1, D16Ertd607e, Psarl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 381038
Homologene: 10239
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Fbxo8
Name: F-box protein 8
Synonyms: Fbx8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50753
Homologene: 8137
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216613
Homologene: 65605
Nt5m
Name: 5',3'-nucleotidase, mitochondrial
Synonyms: dNT-2, 2010013E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103850
Homologene: 10622
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Olfr981
Name: olfactory receptor 981
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258283
VEGA: 9
Homologene: 64849
Olfr1198
Name: olfactory receptor 1198
Synonyms: GA_x6K02T2Q125-50221692-50220766, MOR225-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404330
Homologene: 138634
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56395
Homologene: 135207
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: KATIII, Kat3, Ccbl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229905
Homologene: 2994
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b, Gm10937
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77531
Homologene: 51570
Jrkl
Name: Jrk-like
Synonyms: C030035D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77532
VEGA: 9
HGNC: HGNC:6200
Homologene: 2797
Rhbdd3
Name: rhomboid domain containing 3
Synonyms: 5730411O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 279766
HGNC: HGNC:1308
Homologene: 8175
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24056
Homologene: 23450
Rps6-ps2
Name: ribosomal protein S6, pseudogene 2
Synonyms: Gm16406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 675985
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Zmynd12
Name: zinc finger, MYND domain containing 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 332934
Homologene: 12993
D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Bzrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Trgc1
Name: T cell receptor gamma, constant 1
Synonyms: Cgamma1, Gm17004, Tcrg-C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107573
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 8,463,443 bp
  • G to A, chromosome 1 at 14,183,252 bp
  • T to C, chromosome 1 at 75,419,129 bp
  • C to T, chromosome 2 at 25,056,067 bp
  • A to T, chromosome 2 at 88,746,750 bp
  • T to A, chromosome 2 at 98,666,620 bp
  • T to C, chromosome 2 at 111,408,688 bp
  • T to C, chromosome 2 at 121,014,702 bp
  • A to T, chromosome 2 at 168,098,626 bp
  • G to A, chromosome 3 at 83,766,839 bp
  • C to T, chromosome 3 at 104,464,072 bp
  • T to C, chromosome 3 at 114,217,103 bp
  • A to C, chromosome 3 at 125,438,609 bp
  • T to C, chromosome 3 at 129,299,094 bp
  • C to A, chromosome 3 at 142,734,582 bp
  • T to A, chromosome 4 at 116,605,805 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • T to A, chromosome 4 at 119,441,901 bp
  • G to A, chromosome 4 at 126,180,486 bp
  • G to T, chromosome 4 at 139,375,380 bp
  • A to G, chromosome 4 at 154,015,683 bp
  • C to T, chromosome 5 at 104,207,086 bp
  • G to T, chromosome 5 at 114,450,765 bp
  • T to A, chromosome 5 at 147,455,172 bp
  • T to G, chromosome 5 at 150,988,466 bp
  • T to A, chromosome 6 at 28,419,233 bp
  • A to G, chromosome 6 at 121,302,741 bp
  • T to A, chromosome 6 at 124,540,950 bp
  • C to A, chromosome 7 at 28,317,763 bp
  • A to G, chromosome 8 at 36,146,813 bp
  • T to C, chromosome 8 at 45,775,632 bp
  • A to G, chromosome 8 at 56,591,517 bp
  • A to T, chromosome 8 at 88,806,484 bp
  • C to T, chromosome 9 at 13,244,382 bp
  • T to G, chromosome 9 at 40,022,435 bp
  • A to G, chromosome 9 at 107,534,855 bp
  • G to A, chromosome 10 at 3,990,002 bp
  • A to C, chromosome 10 at 90,914,711 bp
  • G to A, chromosome 10 at 117,215,680 bp
  • T to C, chromosome 10 at 121,825,636 bp
  • A to G, chromosome 10 at 123,008,239 bp
  • T to A, chromosome 11 at 5,105,707 bp
  • A to T, chromosome 11 at 28,392,854 bp
  • T to G, chromosome 11 at 59,852,823 bp
  • T to A, chromosome 11 at 87,777,126 bp
  • A to G, chromosome 11 at 95,029,025 bp
  • T to C, chromosome 11 at 98,693,669 bp
  • A to T, chromosome 13 at 19,216,559 bp
  • T to A, chromosome 13 at 45,539,020 bp
  • T to C, chromosome 13 at 59,500,515 bp
  • A to T, chromosome 13 at 68,620,819 bp
  • A to T, chromosome 13 at 68,642,569 bp
  • T to C, chromosome 13 at 89,678,134 bp
  • T to C, chromosome 13 at 93,098,176 bp
  • T to C, chromosome 13 at 97,093,618 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • A to G, chromosome 14 at 47,016,565 bp
  • A to T, chromosome 14 at 75,331,960 bp
  • T to A, chromosome 15 at 94,325,971 bp
  • A to G, chromosome 16 at 20,287,978 bp
  • A to G, chromosome 16 at 59,559,166 bp
  • T to C, chromosome 16 at 87,488,821 bp
  • T to A, chromosome 17 at 46,923,465 bp
  • A to T, chromosome 18 at 24,272,750 bp
  • T to C, chromosome 19 at 6,345,642 bp
  • T to G, chromosome 19 at 8,773,312 bp
  • G to T, chromosome X at 170,678,016 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5687 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043320-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.