Strain Name:
C57BL/6J-MtgxR5694Btlr/Mmmh
Stock Number:
043325-MU
Citation ID:
RRID:MMRRC_043325-MU
Other Names:
R5694 (G1)
Major Collection:

Strain Information

Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: p42mapk, MAPK2, 9030612K14Rik, Prkm1, Erk2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Phf14
Name: PHD finger protein 14
Synonyms: 5730446A07Rik, 1110001C23Rik, 4932409F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22643
Homologene: 137226
Stk4
Name: serine/threonine kinase 4
Synonyms: Kas-2, sterile 20-like kinase 1, Ysk3, Mst1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58231
Homologene: 55965
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Armc8
Name: armadillo repeat containing 8
Synonyms: 1200015K23Rik, Gid5, HSPC056
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74125
Homologene: 9121
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Actr1a
Name: ARP1 actin-related protein 1A, centractin alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54130
VEGA: 19
HGNC: HGNC:167
Homologene: 21173
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, crf11, eyes2, QBRICK
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Unc5b
Name: unc-5 netrin receptor B
Synonyms: Unc5h2, 6330415E02Rik, D10Bwg0792e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Serinc5
Name: serine incorporator 5
Synonyms: TPO1, AIGP3, A130038L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218442
VEGA: 13
Homologene: 65246
Angptl2
Name: angiopoietin-like 2
Synonyms: Arp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26360
HGNC: HGNC:490
Homologene: 22695
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: Ugcgl1, A930007H10Rik, C820010P03Rik, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Siglech
Name: sialic acid binding Ig-like lectin H
Synonyms: Siglec-H, 6430529G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233274
Homologene: 48041
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Nphs2
Name: nephrosis 2, podocin
Synonyms: podocin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170484
Homologene: 22826
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Cat
Name: catalase
Synonyms: Cs-1, Cas-1, Cas1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Myo16
Name: myosin XVI
Synonyms: Nyap3, C230040D10Rik, BM140241
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56079
Homologene: 77850
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 442827
Homologene: 53300
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: Sur2, SUR2A, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108657
Homologene: 36367
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Erg
Name: ETS transcription factor
Synonyms: D030036I24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13876
HGNC: HGNC:3446
Homologene: 15848
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Adamtsl2
Name: ADAMTS-like 2
Synonyms: stb, A930008K15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77794
Homologene: 8798
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Or12j4
Name: olfactory receptor family 12 subfamily J member 4
Synonyms: MOR252-3P, GA_x6K02T2PBJ9-42615403-42616365, Olfr533
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258056
Homologene: 128384
Or8b1
Name: olfactory receptor family 8 subfamily B member 1
Synonyms: GA_x6K02T2PVTD-32194085-32195020, MOR167-2, Olfr906
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Meig1
Name: meiosis expressed gene 1
Synonyms: Meg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104362
Homologene: 56414
Epha10
Name: Eph receptor A10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230735
Homologene: 67804
Tor4a
Name: torsin family 4, member A
Synonyms: A830007P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227612
Homologene: 17140
Trim12a
Name: tripartite motif-containing 12A
Synonyms: 2310043C01Rik, Trim12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76681
Tbc1d10c
Name: TBC1 domain family, member 10c
Synonyms: 1810062O14Rik, Carabin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108995
VEGA: 19
Homologene: 77854
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Rnf222
Name: ring finger protein 222
Synonyms: 9930039A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320040
Homologene: 18544
Plscr5
Name: phospholipid scramblase family, member 5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504689
Homologene: 28688
BC021891
Name:
Type: Gene
Species: Mouse
Chromosome: 8
Igkv4-51
Name: immunoglobulin kappa chain variable 4-51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 619806
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,179,656 bp
  • T to C, chromosome 1 at 92,918,941 bp
  • A to T, chromosome 1 at 107,535,457 bp
  • T to C, chromosome 1 at 156,326,037 bp
  • G to A, chromosome 1 at 191,586,618 bp
  • T to A, chromosome 2 at 3,411,962 bp
  • T to C, chromosome 2 at 25,194,920 bp
  • A to G, chromosome 2 at 27,081,724 bp
  • T to C, chromosome 2 at 33,228,616 bp
  • A to T, chromosome 2 at 103,472,994 bp
  • C to T, chromosome 2 at 164,100,564 bp
  • A to C, chromosome 3 at 159,839,987 bp
  • T to A, chromosome 4 at 45,035,970 bp
  • T to C, chromosome 4 at 65,950,138 bp
  • A to G, chromosome 4 at 82,994,116 bp
  • C to T, chromosome 4 at 124,902,653 bp
  • C to A, chromosome 5 at 23,991,796 bp
  • C to A, chromosome 6 at 11,990,125 bp
  • C to T, chromosome 6 at 69,681,927 bp
  • G to A, chromosome 6 at 113,399,708 bp
  • T to A, chromosome 6 at 141,250,502 bp
  • A to T, chromosome 6 at 142,600,947 bp
  • T to A, chromosome 7 at 55,768,656 bp
  • C to A, chromosome 7 at 104,307,243 bp
  • TCCCC to TCCC, chromosome 7 at 110,124,569 bp
  • T to C, chromosome 7 at 140,466,731 bp
  • A to G, chromosome 8 at 10,569,606 bp
  • A to G, chromosome 8 at 125,944,768 bp
  • T to A, chromosome 9 at 38,488,236 bp
  • A to T, chromosome 9 at 92,205,511 bp
  • A to G, chromosome 9 at 99,496,149 bp
  • T to A, chromosome 10 at 4,035,239 bp
  • A to C, chromosome 10 at 18,784,287 bp
  • G to A, chromosome 10 at 60,773,747 bp
  • A to T, chromosome 10 at 61,229,652 bp
  • T to A, chromosome 10 at 88,414,486 bp
  • A to T, chromosome 10 at 128,484,127 bp
  • A to G, chromosome 11 at 68,892,897 bp
  • T to G, chromosome 11 at 77,188,875 bp
  • C to A, chromosome 12 at 69,590,915 bp
  • A to G, chromosome 13 at 92,688,794 bp
  • A to T, chromosome 13 at 102,774,193 bp
  • T to G, chromosome 16 at 17,018,469 bp
  • C to A, chromosome 16 at 95,361,031 bp
  • C to A, chromosome 17 at 21,397,759 bp
  • T to C, chromosome 17 at 29,140,500 bp
  • T to A, chromosome 17 at 29,145,966 bp
  • T to C, chromosome 17 at 33,380,945 bp
  • G to T, chromosome 18 at 36,998,372 bp
  • T to C, chromosome 18 at 49,894,257 bp
  • A to T, chromosome 19 at 4,184,964 bp
  • T to C, chromosome 19 at 36,057,121 bp
  • C to A, chromosome 19 at 46,395,718 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5694 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043325-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.