Strain Name:
C57BL/6J-MtgxR5712Btlr
Stock Number:
043334-MU
Citation ID:
RRID:MMRRC_043334-MU
Other Names:
R5712 (G1)
Major Collection:

Gene Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Maco1
Name: macoilin 1
Synonyms: Tmem57, 9230118A01Rik, C61, 1110007C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66146
Homologene: 14449
Wnt7a
Name: wingless-type MMTV integration site family, member 7A
Synonyms: tw, Wnt-7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22421
Homologene: 20969
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2810454G14Rik, 2610102K23Rik, 2700025J07Rik, 5730534O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72567
Homologene: 8832
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18541
VEGA: 10
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: SAP25, LRN, 2810008P14Rik, LRRN4, 2900069C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70373
VEGA: 12
Homologene: 9942
Lck
Name: lymphocyte protein tyrosine kinase
Synonyms: Hck-3, p56lck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16818
HGNC: HGNC:6524
Homologene: 3911
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30054
VEGA: 14
Homologene: 23727
Gpr3
Name: G-protein coupled receptor 3
Synonyms: Gpcr3, Gpcr21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14748
HGNC: HGNC:4484
Homologene: 31303
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 4921513O20Rik, D630001M17Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66725
Homologene: 18982
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230895
Homologene: 15583
Aspn
Name: asporin
Synonyms: SLRR1C, 4631401G09Rik, PLAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66695
VEGA: 13
Homologene: 32357
Mknk1
Name: MAP kinase-interacting serine/threonine kinase 1
Synonyms: 2410048M24Rik, Mnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17346
HGNC: HGNC:7110
Homologene: 37838
Soga1
Name: suppressor of glucose, autophagy associated 1
Synonyms: 9830001H06Rik, D430036N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320706
Homologene: 52382
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16532
Homologene: 7392
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Rdh19
Name: retinol dehydrogenase 19
Synonyms: RDH-S, Rdhs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216453
Homologene: 129514
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: C79217, Cav1.3alpha1, 8430418G19Rik, Cchl1a2, Cacnl1a2, D-LTCC, Cchl1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 210510
Homologene: 19364
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Synpo2
Name: synaptopodin 2
Synonyms: 2310068J10Rik, 1110069I04Rik, Myo, myopodin, 9530006G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 118449
Homologene: 15400
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18080
Homologene: 40632
Fbxo17
Name: F-box protein 17
Synonyms: FBXO26, Fbx17, Fbg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 50760
Homologene: 17523
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: LOC384050, C130004B06Rik, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68625
Homologene: 51350
Vmn1r176
Name: vomeronasal 1 receptor 176
Synonyms: Gm5998
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 546943
Homologene: 128341
Tmigd1
Name: transmembrane and immunoglobulin domain containing 1
Synonyms: 2010002A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66601
Homologene: 41641
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, Hgfl, DNF15S2h, D3F15S2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
1700018F24Rik
Name: RIKEN cDNA 1700018F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69396
Homologene: 86127
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58909
Homologene: 135847
Uap1
Name: UDP-N-acetylglucosamine pyrophosphorylase 1
Synonyms: ESTM38, SPAG2, AgX, AGX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 107652
Homologene: 2342
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 236573
Homologene: 128731
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Exoc3l4
Name: exocyst complex component 3-like 4
Synonyms: 1600013K19Rik, 1200009I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74190
VEGA: 12
Homologene: 41760
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228482
Homologene: 8862
Phc2
Name: polyhomeotic 2
Synonyms: D4Ertd810e, D130050K19Rik, Edr2, Mph2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Med11
Name: mediator complex subunit 11
Synonyms: 1110030J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66172
Homologene: 32630
Erich6b
Name: glutamate rich 6B
Synonyms: Gm46471, 4930564B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 108168181
VEGA: 14
Homologene: 67175
Sirt7
Name: sirtuin 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 209011
Homologene: 56152
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 211255
VEGA: 14
Homologene: 41849
Trim3
Name: tripartite motif-containing 3
Synonyms: HAC1, BERP1, Rnf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 55992
Homologene: 21290
Alkbh1
Name: alkB homolog 1, histone H2A dioxygenase
Synonyms: Nrp, alkB, Alkbh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 211064
Homologene: 4393
Tmem190
Name: transmembrane protein 190
Synonyms: 4930572D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 78052
Homologene: 44548
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: FACVL3, FATP5, VLCSH2, VLCS-H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26459
Homologene: 7596
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: PLRLC-A, PLRLC-C, PLRLC, 1700027I08Rik, Mylc2pl, PLRLC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59310
Homologene: 69341
Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Synonyms: 2410008K03Rik, Gatsl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71962
Homologene: 81920
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 52,196,752 bp
  • A to C, chromosome 1 at 133,730,540 bp
  • A to G, chromosome 1 at 170,166,845 bp
  • T to C, chromosome 2 at 83,008,848 bp
  • T to C, chromosome 2 at 113,845,301 bp
  • T to A, chromosome 2 at 157,030,921 bp
  • C to T, chromosome 3 at 83,033,133 bp
  • T to A, chromosome 3 at 89,051,990 bp
  • T to A, chromosome 3 at 123,121,210 bp
  • A to G, chromosome 4 at 115,855,006 bp
  • G to T, chromosome 4 at 118,614,795 bp
  • A to G, chromosome 4 at 128,745,095 bp
  • G to T, chromosome 4 at 129,556,310 bp
  • A to G, chromosome 4 at 133,210,408 bp
  • A to T, chromosome 4 at 134,828,058 bp
  • A to C, chromosome 4 at 145,087,173 bp
  • T to A, chromosome 5 at 105,094,555 bp
  • T to C, chromosome 5 at 136,694,238 bp
  • A to G, chromosome 5 at 137,400,098 bp
  • A to C, chromosome 5 at 137,637,926 bp
  • A to G, chromosome 5 at 145,044,753 bp
  • T to A, chromosome 6 at 58,956,699 bp
  • T to C, chromosome 6 at 91,366,204 bp
  • G to A, chromosome 7 at 4,784,289 bp
  • T to C, chromosome 7 at 12,998,083 bp
  • A to T, chromosome 7 at 23,835,500 bp
  • G to A, chromosome 7 at 28,737,472 bp
  • T to A, chromosome 7 at 105,619,536 bp
  • T to A, chromosome 8 at 25,919,650 bp
  • A to G, chromosome 8 at 60,937,298 bp
  • C to T, chromosome 9 at 31,414,636 bp
  • T to C, chromosome 9 at 108,082,908 bp
  • T to G, chromosome 10 at 20,333,531 bp
  • T to C, chromosome 10 at 76,429,271 bp
  • T to A, chromosome 10 at 127,856,887 bp
  • T to C, chromosome 11 at 4,218,378 bp
  • A to G, chromosome 11 at 70,453,232 bp
  • T to C, chromosome 11 at 76,907,032 bp
  • A to T, chromosome 11 at 87,874,853 bp
  • A to T, chromosome 11 at 120,620,851 bp
  • T to C, chromosome 12 at 70,042,769 bp
  • A to G, chromosome 12 at 86,244,480 bp
  • A to G, chromosome 12 at 87,429,113 bp
  • T to A, chromosome 12 at 111,424,042 bp
  • A to T, chromosome 13 at 49,563,519 bp
  • A to G, chromosome 14 at 30,074,997 bp
  • G to A, chromosome 14 at 56,471,399 bp
  • T to A, chromosome 14 at 75,658,900 bp
  • T to C, chromosome 14 at 79,428,765 bp
  • C to T, chromosome 15 at 64,754,866 bp
  • A to T, chromosome 15 at 91,702,222 bp
  • C to A, chromosome 17 at 43,626,408 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5712 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043334-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.