Strain Name:
C57BL/6J-MtgxR5757Btlr
Stock Number:
043360-MU
Citation ID:
RRID:MMRRC_043360-MU
Other Names:
R5757 (G1)
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57810
Homologene: 22996
Arid5b
Name: AT rich interactive domain 5B (MRF1-like)
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Spop
Name: speckle-type BTB/POZ protein
Synonyms: TEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20747
Homologene: 68354
Brd4
Name: bromodomain containing 4
Synonyms: MCAP, HUNK1, WI-11513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57261
Homologene: 136213
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, DIL2, p100, 2610005B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, F730017H24Rik, D14Ertd453e, Fndc3, sys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319448
Homologene: 8952
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: Npac, 2810419J22Rik, 3930401K13Rik, NDF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Wdr4
Name: WD repeat domain 4
Synonyms: D530049K22Rik, Wh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57773
Homologene: 32422
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271377
Homologene: 8678
Sfrp2
Name: secreted frizzled-related protein 2
Synonyms: Sdf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20319
Homologene: 56438
Clec4b1
Name: C-type lectin domain family 4, member b1
Synonyms: 1810046I24Rik, 1810046I24Rik, DCARbeta, DCAR, mDcar2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69810
Homologene: 130350
Scnn1g
Name: sodium channel, nonvoltage-gated 1 gamma
Synonyms: ENaC gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20278
Homologene: 20280
Klhl14
Name: kelch-like 14
Synonyms: 6330403N15Rik, printor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225266
Homologene: 28121
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Fbxo30
Name: F-box protein 30
Synonyms: 1700026A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71865
Homologene: 12959
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78016
Homologene: 15814
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381489
Homologene: 11007
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76850
Homologene: 41184
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230872
Homologene: 16811
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Clip50, CLIP-170, 1110007I12Rik, 4631429H07Rik, Rsn, Clip 170, restin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Or8k27
Name: olfactory receptor family 8 subfamily K member 27
Synonyms: GA_x6K02T2Q125-47915274-47914333, MOR190-1, Olfr1065
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258403
Homologene: 74195
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98733
Prr14
Name: proline rich 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233895
Homologene: 11424
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Or5m9
Name: olfactory receptor family 5 subfamily M member 9
Synonyms: GA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR227-8P, MOR245-14P, Olfr1533-ps1, Olfr1034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258216
Homologene: 51741
Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Synonyms: Gnas1, Gs-alpha, Gs alpha, G alpha s, Nesp55, neuroendocrine-specific Golgi protein p55 isoform 1, XLalphas, P2, P3, P1, Gsa, Nesp, Gnasxl, Nespl, Oedsml, Galphas, SCG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: E330010H22Rik, uPFK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Gm525
Name: predicted gene 525
Synonyms: LOC217071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217071
Homologene: 129636
Asgr1
Name: asialoglycoprotein receptor 1
Synonyms: Asgr-1, Asgr, ASGPR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11889
HGNC: HGNC:742
Homologene: 1263
Zfp703
Name: zinc finger protein 703
Synonyms: 1110032O19Rik, Csmn1, End2, Zeppo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353310
Homologene: 81391
Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Asun
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Fam101b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 54,263,620 bp
  • G to T, chromosome 1 at 75,493,055 bp
  • A to T, chromosome 2 at 11,480,330 bp
  • T to A, chromosome 2 at 86,046,566 bp
  • T to C, chromosome 2 at 86,445,578 bp
  • G to A, chromosome 2 at 112,841,975 bp
  • A to G, chromosome 2 at 152,885,231 bp
  • T to C, chromosome 2 at 155,411,608 bp
  • T to A, chromosome 2 at 174,345,247 bp
  • T to G, chromosome 3 at 79,661,320 bp
  • G to C, chromosome 3 at 83,766,626 bp
  • A to C, chromosome 4 at 9,637,722 bp
  • A to T, chromosome 4 at 63,170,518 bp
  • A to T, chromosome 4 at 126,526,084 bp
  • A to T, chromosome 4 at 141,043,564 bp
  • G to C, chromosome 5 at 121,348,619 bp
  • G to A, chromosome 5 at 123,627,397 bp
  • T to C, chromosome 5 at 123,807,309 bp
  • A to T, chromosome 6 at 112,477,261 bp
  • T to A, chromosome 6 at 123,069,754 bp
  • G to A, chromosome 6 at 146,550,106 bp
  • T to A, chromosome 7 at 46,241,121 bp
  • T to A, chromosome 7 at 121,738,215 bp
  • T to A, chromosome 7 at 127,475,553 bp
  • C to T, chromosome 8 at 26,979,205 bp
  • A to C, chromosome 9 at 35,452,772 bp
  • T to A, chromosome 10 at 11,290,421 bp
  • T to C, chromosome 10 at 68,102,079 bp
  • C to T, chromosome 11 at 55,252,346 bp
  • A to C, chromosome 11 at 70,054,952 bp
  • A to G, chromosome 11 at 76,022,166 bp
  • A to T, chromosome 11 at 89,075,046 bp
  • A to G, chromosome 11 at 95,490,382 bp
  • C to T, chromosome 11 at 110,042,968 bp
  • A to T, chromosome 12 at 69,824,655 bp
  • A to C, chromosome 13 at 96,484,252 bp
  • T to C, chromosome 14 at 72,556,585 bp
  • A to T, chromosome 15 at 77,771,162 bp
  • A to G, chromosome 15 at 90,951,345 bp
  • A to T, chromosome 16 at 5,018,992 bp
  • G to T, chromosome 16 at 35,272,081 bp
  • C to T, chromosome 16 at 37,086,681 bp
  • A to G, chromosome 16 at 56,007,029 bp
  • A to T, chromosome 17 at 31,499,089 bp
  • G to A, chromosome 17 at 32,201,298 bp
  • G to A, chromosome 17 at 67,738,787 bp
  • T to A, chromosome 17 at 75,273,949 bp
  • A to C, chromosome 18 at 21,554,734 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5757 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043360-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.