Strain Name:
C57BL/6J-MtgxR5760Btlr
Stock Number:
043362-MU
Citation ID:
RRID:MMRRC_043362-MU
Other Names:
R5760 (G1)
Major Collection:

Strain Information

Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 171286
Homologene: 11628
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Abl2
Name: v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
Synonyms: Arg, Abll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
En2
Name: engrailed 2
Synonyms: En-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13799
HGNC: HGNC:3343
Homologene: 55579
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 58198
Homologene: 2230
Lix1
Name: limb and CNS expressed 1
Synonyms: 5730466L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66643
Homologene: 12004
Tgif1
Name: TGFB-induced factor homeobox 1
Synonyms: Tgif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21815
Homologene: 7574
Drap1
Name: Dr1 associated protein 1 (negative cofactor 2 alpha)
Synonyms: 2310074H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66556
HGNC: HGNC:3019
Homologene: 4703
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Dennd6a
Name: DENN/MADD domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211922
Homologene: 13503
Zfp808
Name: zinc finger protein 808
Synonyms: Gm7036
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 630579
Homologene: 134631
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72685
Homologene: 8865
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56523
Homologene: 23182
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (non-functional)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329470
Homologene: 75335
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: A630038G13Rik, Zfp537, teashirt3, Tsh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Or10j7
Name: olfactory receptor family 10 subfamily J member 7
Synonyms: GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258758
Homologene: 133644
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268816
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Gm7535
Name: predicted gene 7535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665187
VEGA: 17
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, 2900056N03Rik, E030045D18Rik, Shn3, Schnurri-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71325
Homologene: 84625
Npm2
Name: nucleophosmin/nucleoplasmin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328440
VEGA: 14
HGNC: HGNC:7930
Homologene: 15349
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: 2810457I06Rik, TULA-2, Sts-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72828
Homologene: 13152
Or6b2b
Name: olfactory receptor family 6 subfamily B member 2B
Synonyms: GA_x6K02T2R7CC-81266841-81267776, MOR103-12, Olfr1415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258228
Homologene: 79367
4930447A16Rik
Name: RIKEN cDNA 4930447A16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74892
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Or7d10
Name: olfactory receptor family 7 subfamily D member 10
Synonyms: 18A, MOR143-1, GA_x6K02T2PVTD-13660026-13660964, Olfr77
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258336
HGNC: HGNC:8380
Homologene: 133688
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Igkv6-15
Name: immunoglobulin kappa variable 6-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108022
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Amica1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,073,554 bp
  • CT to CTT, chromosome 1 at 20,808,748 bp
  • A to G, chromosome 1 at 92,491,200 bp
  • C to T, chromosome 1 at 93,440,777 bp
  • C to T, chromosome 1 at 156,641,857 bp
  • C to A, chromosome 1 at 173,183,751 bp
  • G to A, chromosome 2 at 31,414,568 bp
  • A to C, chromosome 2 at 52,183,818 bp
  • A to C, chromosome 2 at 93,845,760 bp
  • C to T, chromosome 2 at 125,361,247 bp
  • C to G, chromosome 3 at 93,471,556 bp
  • A to T, chromosome 3 at 98,880,432 bp
  • G to A, chromosome 4 at 101,618,642 bp
  • A to G, chromosome 4 at 120,095,011 bp
  • A to G, chromosome 4 at 123,513,884 bp
  • C to A, chromosome 5 at 28,166,999 bp
  • A to G, chromosome 5 at 66,362,757 bp
  • T to A, chromosome 5 at 72,260,937 bp
  • G to A, chromosome 6 at 35,247,343 bp
  • A to T, chromosome 6 at 70,406,532 bp
  • C to A, chromosome 7 at 36,771,569 bp
  • A to T, chromosome 7 at 128,203,365 bp
  • A to T, chromosome 8 at 25,659,756 bp
  • G to T, chromosome 8 at 71,387,368 bp
  • T to C, chromosome 8 at 89,028,650 bp
  • A to T, chromosome 8 at 109,521,023 bp
  • A to C, chromosome 9 at 19,920,754 bp
  • T to G, chromosome 9 at 41,077,423 bp
  • T to A, chromosome 9 at 45,097,754 bp
  • C to T, chromosome 10 at 60,406,392 bp
  • A to T, chromosome 11 at 6,229,031 bp
  • A to T, chromosome 13 at 62,171,926 bp
  • A to C, chromosome 13 at 67,257,789 bp
  • T to A, chromosome 13 at 73,813,622 bp
  • T to G, chromosome 13 at 100,242,838 bp
  • A to T, chromosome 14 at 26,612,040 bp
  • A to G, chromosome 14 at 70,649,495 bp
  • T to A, chromosome 15 at 34,355,607 bp
  • T to C, chromosome 15 at 37,439,591 bp
  • A to C, chromosome 15 at 73,821,507 bp
  • G to T, chromosome 16 at 33,624,785 bp
  • T to A, chromosome 17 at 17,427,237 bp
  • C to T, chromosome 17 at 17,911,818 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to G, chromosome 17 at 70,845,001 bp
  • G to A, chromosome 18 at 37,146,400 bp
  • A to G, chromosome 19 at 5,424,363 bp
  • A to T, chromosome 19 at 9,013,562 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5760 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043362-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.