Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR5763Btlr/Mmmh
Stock Number:
043364-MU
Citation ID:
RRID:MMRRC_043364-MU
Other Names:
R5763 (G1)
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Tnpo1
Name: transportin 1
Synonyms: D13Ertd688e, Kpnb2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
Foxm1
Name: forkhead box M1
Synonyms: Mpm2, WIN, HFH-11B, Trident, Fkh16, Foxm1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14235
HGNC: HGNC:3818
Homologene: 7318
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 130,743,031 bp
  • A to G, chromosome 1 at 155,779,879 bp
  • T to A, chromosome 2 at 30,279,971 bp
  • T to C, chromosome 2 at 37,271,013 bp
  • T to A, chromosome 2 at 89,722,028 bp
  • G to T, chromosome 2 at 165,358,435 bp
  • TGGCCACGCGG to TGG, chromosome 2 at 173,578,089 bp
  • T to C, chromosome 3 at 114,094,596 bp
  • A to T, chromosome 3 at 116,753,360 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • T to C, chromosome 4 at 41,195,809 bp
  • T to A, chromosome 4 at 65,729,331 bp
  • C to T, chromosome 4 at 106,760,130 bp
  • A to T, chromosome 5 at 8,134,544 bp
  • A to G, chromosome 5 at 24,807,787 bp
  • T to C, chromosome 5 at 109,215,858 bp
  • T to A, chromosome 5 at 137,566,801 bp
  • T to C, chromosome 5 at 150,548,006 bp
  • T to A, chromosome 6 at 4,515,682 bp
  • T to C, chromosome 6 at 18,414,299 bp
  • T to G, chromosome 6 at 49,378,584 bp
  • T to A, chromosome 6 at 57,662,887 bp
  • T to C, chromosome 6 at 88,849,823 bp
  • T to A, chromosome 6 at 128,366,108 bp
  • T to A, chromosome 7 at 10,171,304 bp
  • G to T, chromosome 7 at 10,492,366 bp
  • T to A, chromosome 7 at 18,245,662 bp
  • T to A, chromosome 7 at 19,163,550 bp
  • A to T, chromosome 7 at 43,356,320 bp
  • G to A, chromosome 7 at 46,847,789 bp
  • A to T, chromosome 7 at 47,589,607 bp
  • G to A, chromosome 7 at 112,374,654 bp
  • T to A, chromosome 7 at 140,373,655 bp
  • A to G, chromosome 8 at 69,817,851 bp
  • C to T, chromosome 8 at 104,736,124 bp
  • T to A, chromosome 9 at 90,188,409 bp
  • A to G, chromosome 9 at 95,945,123 bp
  • G to T, chromosome 9 at 105,669,775 bp
  • T to G, chromosome 9 at 110,556,275 bp
  • A to T, chromosome 9 at 110,862,449 bp
  • A to T, chromosome 10 at 33,905,688 bp
  • T to A, chromosome 10 at 62,840,068 bp
  • C to A, chromosome 11 at 65,955,239 bp
  • T to A, chromosome 11 at 73,847,867 bp
  • C to A, chromosome 11 at 80,025,308 bp
  • C to T, chromosome 11 at 89,301,465 bp
  • G to A, chromosome 11 at 103,613,643 bp
  • A to G, chromosome 11 at 117,769,433 bp
  • A to G, chromosome 12 at 75,391,832 bp
  • A to G, chromosome 12 at 84,147,350 bp
  • A to G, chromosome 12 at 103,417,414 bp
  • A to C, chromosome 13 at 98,859,937 bp
  • A to T, chromosome 14 at 20,739,347 bp
  • T to C, chromosome 14 at 50,654,068 bp
  • G to T, chromosome 14 at 53,599,387 bp
  • T to C, chromosome 15 at 28,311,152 bp
  • T to C, chromosome 16 at 23,496,247 bp
  • A to G, chromosome 16 at 59,554,610 bp
  • C to A, chromosome 16 at 84,860,409 bp
  • C to T, chromosome 16 at 91,657,490 bp
  • A to T, chromosome 16 at 96,033,843 bp
  • G to A, chromosome 17 at 35,881,688 bp
  • T to C, chromosome 18 at 78,116,414 bp
  • T to C, chromosome 19 at 6,122,110 bp
  • T to C, chromosome 19 at 6,531,339 bp
  • G to T, chromosome 19 at 43,704,266 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5763 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043364-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.