Strain Name:
C57BL/6J-MtgxR5764Btlr/Mmmh
Stock Number:
043365-MU
Citation ID:
RRID:MMRRC_043365-MU
Other Names:
R5764 (G1)
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Khc, D10Bwg0738e, Kns, Kif5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Htr4
Name: 5 hydroxytryptamine (serotonin) receptor 4
Synonyms: 5-HT4L, 5-HT4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15562
VEGA: 18
HGNC: HGNC:5299
Homologene: 20243
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Med13l
Name: mediator complex subunit 13-like
Synonyms: 2210413I17Rik, Trap240L, 6330591G05Rik, 9030618F05Rik, Thrap2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Utp4
Name: UTP4 small subunit processome component
Synonyms: Cirh1a, TEG-292, Tex292
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21771
HGNC: HGNC:1983
Homologene: 40775
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24088
Homologene: 20695
Zfp180
Name: zinc finger protein 180
Synonyms: 2310040I01Rik, HHZ168, D130011P11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Sumf1
Name: sulfatase modifying factor 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58911
Homologene: 16268
Pgr
Name: progesterone receptor
Synonyms: 9930019P03Rik, PR-A, PR-B, ENSMUSG00000074510, NR3C3, PR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 2A-HUB, 6430549P11Rik, 2310047C04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: Tcfap2a, Ap-2 (a), Ap2, AP-2 alpha, Ap2tf, AP2alpha
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
Myadm
Name: myeloid-associated differentiation marker
Synonyms: D7Wsu62e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50918
HGNC: HGNC:7544
Homologene: 9668
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, Plc, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Tcp1
Name: t-complex protein 1
Synonyms: TRic, CCT, Tcp-1, Cct1, Tp63, p63, Ccta, c-cpn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21454
Homologene: 5656
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: LH2, D530025C14Rik, Plod-2, lysyl hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268741
Homologene: 8889
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Jag1
Name: jagged 1
Synonyms: Gsfabe2, Headturner, ABE2, Ozz, Serrate-1, Htu
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, 1500037O19Rik, Munc13-3, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ly75
Name: lymphocyte antigen 75
Synonyms: CD205, DEC-205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17076
Homologene: 31085
Trim10
Name: tripartite motif-containing 10
Synonyms: Rnf9, Herf1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19824
Homologene: 4932
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Serpinf2
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms: Pli, alpha 2 antiplasmin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18816
HGNC: HGNC:9075
Homologene: 719
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: Adrbk-2, 4833444A01Rik, beta ARK2, Adrbk2, Bark-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: Bai1, B830018M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Tmc4
Name: transmembrane channel-like gene family 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353499
Homologene: 16971
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, Pgm1a, 2610020G18Rik, Pgm2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Endou
Name: endonuclease, polyU-specific
Synonyms: Tcl-30, Pp11r
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19011
VEGA: 15
Homologene: 48394
Ngly1
Name: N-glycanase 1
Synonyms: 1110002C09Rik, PNGase, Png1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Entpd1
Name: ectonucleoside triphosphate diphosphohydrolase 1
Synonyms: Cd39, ectoapyrase, 2610206B08Rik, NTPDase-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12495
HGNC: HGNC:3363
Homologene: 20423
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49f, Ly49F
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16637
Homologene: 110821
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: D130016B08Rik, SIP1, Zfx1b, 9130203F04Rik, Zfhx1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Cope
Name: coatomer protein complex, subunit epsilon
Synonyms: 1110005D17Rik, Cope1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59042
HGNC: HGNC:2234
Homologene: 5254
Troap
Name: trophinin associated protein
Synonyms: tastin, E130301L11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78733
VEGA: 15
Homologene: 28697
Pigq
Name: phosphatidylinositol glycan anchor biosynthesis, class Q
Synonyms: Gpi1p, Gpi1, Gpi1h, Gpih
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14755
Homologene: 31228
Hba-a2
Name: hemoglobin alpha, adult chain 2
Synonyms: alpha 2 globin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110257
Homologene: 469
Iglv1
Name: immunoglobulin lambda variable 1
Synonyms: 1810027O01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16142
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,414,875 bp
  • T to C, chromosome 2 at 44,996,919 bp
  • C to T, chromosome 2 at 60,318,439 bp
  • C to T, chromosome 2 at 137,089,247 bp
  • A to C, chromosome 3 at 83,838,512 bp
  • A to G, chromosome 3 at 85,665,865 bp
  • A to G, chromosome 4 at 81,356,446 bp
  • C to T, chromosome 4 at 99,964,846 bp
  • C to A, chromosome 4 at 137,561,721 bp
  • T to C, chromosome 5 at 62,642,854 bp
  • A to G, chromosome 5 at 112,966,910 bp
  • T to A, chromosome 5 at 118,728,642 bp
  • C to T, chromosome 6 at 108,118,463 bp
  • T to A, chromosome 6 at 130,022,729 bp
  • G to A, chromosome 7 at 3,297,252 bp
  • A to T, chromosome 7 at 3,672,023 bp
  • A to G, chromosome 7 at 24,101,484 bp
  • T to C, chromosome 8 at 70,306,581 bp
  • T to G, chromosome 8 at 106,917,616 bp
  • A to T, chromosome 9 at 8,900,537 bp
  • C to T, chromosome 9 at 73,533,903 bp
  • A to G, chromosome 9 at 92,603,021 bp
  • A to T, chromosome 10 at 53,348,994 bp
  • T to A, chromosome 10 at 60,293,406 bp
  • C to T, chromosome 10 at 67,226,512 bp
  • GGGTTGGT to GGGT, chromosome 10 at 127,231,029 bp
  • T to C, chromosome 10 at 127,595,318 bp
  • G to A, chromosome 11 at 30,772,364 bp
  • T to A, chromosome 11 at 32,297,156 bp
  • A to G, chromosome 11 at 75,437,404 bp
  • T to A, chromosome 12 at 103,765,821 bp
  • C to T, chromosome 13 at 14,322,509 bp
  • A to C, chromosome 13 at 40,728,355 bp
  • A to G, chromosome 13 at 46,687,327 bp
  • T to A, chromosome 14 at 16,260,799 bp
  • T to C, chromosome 14 at 52,285,820 bp
  • G to A, chromosome 15 at 74,541,574 bp
  • G to A, chromosome 15 at 97,714,607 bp
  • T to A, chromosome 15 at 99,075,419 bp
  • T to C, chromosome 16 at 19,085,440 bp
  • T to G, chromosome 16 at 37,017,344 bp
  • A to G, chromosome 16 at 48,927,361 bp
  • A to G, chromosome 17 at 12,916,602 bp
  • A to T, chromosome 17 at 25,932,119 bp
  • A to T, chromosome 17 at 36,870,181 bp
  • G to A, chromosome 18 at 62,437,542 bp
  • A to T, chromosome 19 at 40,738,973 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5764 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043365-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.