Strain Name:
C57BL/6J-MtgxR5769Btlr
Stock Number:
043369-MU
Citation ID:
RRID:MMRRC_043369-MU
Other Names:
R5769 (G1)
Major Collection:

Gene Information

Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: 1110001J02Rik, p110beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227699
Homologene: 45683
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 52184
Homologene: 12011
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230661
Homologene: 5188
Jrk
Name: jerky
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16469
HGNC: HGNC:6199
Homologene: 2762
Fbxo38
Name: F-box protein 38
Synonyms: SP329, 6030410I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107035
VEGA: 18
Homologene: 34526
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: 2610042O15Rik, Mms19, C86341, Mms19l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72199
Homologene: 41480
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Gm14124
Name: predicted gene 14124
Synonyms: EG640962, Gm10749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100216455
Homologene: 134546
Dtna
Name: dystrobrevin alpha
Synonyms: alpha-dystrobrevin, A0, 87K protein, Dtn, adbn, a-DB-1, 2210407P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Gins1
Name: GINS complex subunit 1 (Psf1 homolog)
Synonyms: Psf1, 2810418N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69270
Homologene: 44516
Rxrb
Name: retinoid X receptor beta
Synonyms: RCoR-1, H-2RIIBP, Nr2b2, Rub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20182
Homologene: 7923
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Ppp2r5a
Name: protein phosphatase 2, regulatory subunit B', alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226849
HGNC: HGNC:9309
Homologene: 55961
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67095
Homologene: 25103
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217337
Homologene: 7056
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Magel2
Name: MAGE family member L2
Synonyms: NDNL1, Mage-l2, nM15, ns7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: ERp72, Erp72, Cai, U48620
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12304
Homologene: 21020
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Susd2
Name: sushi domain containing 2
Synonyms: 1200011D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71733
VEGA: 10
Homologene: 10481
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: F630004O05Rik, B930091H02Rik, D030022P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Vmn1r33
Name: vomeronasal 1 receptor 33
Synonyms: V1rc14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171187
Homologene: 110800
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67543
VEGA: 17
Homologene: 129776
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242594
Homologene: 52981
Rida
Name: reactive intermediate imine deaminase A homolog
Synonyms: HRP12, HR12, Hrsp12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15473
Homologene: 4261
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78771
Homologene: 75211
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243308
Homologene: 65621
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104015
Homologene: 48252
Acap3
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Synonyms: Kiaa1716-hp, Centb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140500
Homologene: 23708
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Hdac10
Name: histone deacetylase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170787
Homologene: 23749
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16950
Homologene: 56591
Hes6
Name: hairy and enhancer of split 6
Synonyms: bHLHb41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 55927
Homologene: 23111
Lyg1
Name: lysozyme G-like 1
Synonyms: 2300002O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69541
Homologene: 18376
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Tmem41b
Name: transmembrane protein 41B
Synonyms: 1500031M19Rik, D7Ertd70e, 1500015G02Rik, D7Ertd743e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233724
Homologene: 42740
Otud3
Name: OTU domain containing 3
Synonyms: 3110030K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73162
Homologene: 66103
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, glide, Gcm a, Gcm 1, Gcm1-rs1, GCMa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Coq8a
Name: coenzyme Q8A
Synonyms: 4632432J16Rik, Cabc1, Adck3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67426
Homologene: 11345
Syt12
Name: synaptotagmin XII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171180
Homologene: 15895
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 278279
Homologene: 25521
Rdh16f2
Name: RDH16 family member 2
Synonyms: BC089597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216454
Homologene: 129514
Preb
Name: prolactin regulatory element binding
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50907
HGNC: HGNC:9356
Homologene: 40877
Defb33
Name: defensin beta 33
Synonyms: EG654453
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 654453
Wash1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Gm12845
Name: predicted gene 12845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100416740
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,950,750 bp
  • G to T, chromosome 1 at 91,412,949 bp
  • A to G, chromosome 1 at 135,452,257 bp
  • A to G, chromosome 1 at 180,179,116 bp
  • T to C, chromosome 1 at 191,372,666 bp
  • A to G, chromosome 2 at 30,330,735 bp
  • G to A, chromosome 2 at 104,434,953 bp
  • A to G, chromosome 2 at 150,268,278 bp
  • A to T, chromosome 2 at 150,925,998 bp
  • T to A, chromosome 3 at 72,928,235 bp
  • A to G, chromosome 3 at 145,135,731 bp
  • G to T, chromosome 4 at 105,013,321 bp
  • T to A, chromosome 4 at 105,015,644 bp
  • A to G, chromosome 4 at 116,802,315 bp
  • A to C, chromosome 4 at 117,728,965 bp
  • T to A, chromosome 4 at 138,898,110 bp
  • A to T, chromosome 4 at 155,902,400 bp
  • A to C, chromosome 5 at 8,683,426 bp
  • G to T, chromosome 5 at 30,958,291 bp
  • G to A, chromosome 5 at 32,317,522 bp
  • T to C, chromosome 5 at 120,916,854 bp
  • T to A, chromosome 5 at 138,646,333 bp
  • A to G, chromosome 6 at 47,815,512 bp
  • T to A, chromosome 6 at 66,611,833 bp
  • A to G, chromosome 6 at 83,050,600 bp
  • A to C, chromosome 7 at 12,615,282 bp
  • T to A, chromosome 7 at 62,378,113 bp
  • G to A, chromosome 7 at 109,978,738 bp
  • G to A, chromosome 7 at 120,089,952 bp
  • T to A, chromosome 7 at 127,559,822 bp
  • T to A, chromosome 8 at 20,897,527 bp
  • A to T, chromosome 8 at 71,386,219 bp
  • A to G, chromosome 9 at 78,064,967 bp
  • G to A, chromosome 9 at 99,093,159 bp
  • A to T, chromosome 9 at 121,448,838 bp
  • T to C, chromosome 10 at 20,960,082 bp
  • C to T, chromosome 10 at 75,638,019 bp
  • T to C, chromosome 10 at 105,370,046 bp
  • A to T, chromosome 10 at 127,876,889 bp
  • A to T, chromosome 11 at 86,346,003 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • A to G, chromosome 11 at 116,246,669 bp
  • T to A, chromosome 12 at 98,790,619 bp
  • A to G, chromosome 13 at 76,759,808 bp
  • T to A, chromosome 13 at 112,953,717 bp
  • T to C, chromosome 15 at 34,484,558 bp
  • T to C, chromosome 15 at 74,706,068 bp
  • T to C, chromosome 15 at 89,123,616 bp
  • C to T, chromosome 16 at 9,761,526 bp
  • A to G, chromosome 16 at 90,938,253 bp
  • A to T, chromosome 17 at 9,667,843 bp
  • T to C, chromosome 17 at 34,032,847 bp
  • A to T, chromosome 17 at 66,118,116 bp
  • A to T, chromosome 18 at 23,651,554 bp
  • A to T, chromosome 18 at 58,105,199 bp
  • G to A, chromosome 18 at 62,514,965 bp
  • T to C, chromosome 19 at 4,451,044 bp
  • A to G, chromosome 19 at 41,964,386 bp
  • T to A, chromosome 19 at 47,102,637 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5769 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043369-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.