Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR5771Btlr/Mmmh
Stock Number:
043371-MU
Citation ID:
RRID:MMRRC_043371-MU
Other Names:
R5771 (G1)
Major Collection:

Strain Information

Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: Kv9.2, E130006J24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Slamf6
Name: SLAM family member 6
Synonyms: SF2000, NTB-A, KAL1b, KAL1, Ly108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30925
Homologene: 49945
Gcm2
Name: glial cells missing homolog 2
Synonyms: Gcm1-rs2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107889
VEGA: 13
HGNC: HGNC:4198
Homologene: 3490
Ctnnal1
Name: catenin alpha like 1
Synonyms: ACRP, Catnal1, catenin (cadherin associated protein), alpha-like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54366
HGNC: HGNC:2512
Homologene: 2815
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,369,042 bp
  • A to G, chromosome 1 at 33,454,151 bp
  • G to A, chromosome 1 at 46,639,665 bp
  • T to C, chromosome 1 at 87,446,328 bp
  • A to T, chromosome 1 at 134,773,424 bp
  • T to G, chromosome 1 at 153,141,594 bp
  • G to A, chromosome 1 at 171,917,774 bp
  • A to T, chromosome 2 at 88,446,308 bp
  • C to T, chromosome 2 at 90,723,396 bp
  • T to A, chromosome 2 at 111,450,061 bp
  • A to C, chromosome 2 at 121,021,820 bp
  • T to C, chromosome 2 at 126,378,744 bp
  • T to A, chromosome 2 at 164,973,768 bp
  • T to A, chromosome 3 at 31,238,707 bp
  • T to C, chromosome 3 at 67,435,562 bp
  • A to T, chromosome 3 at 87,263,468 bp
  • G to A, chromosome 3 at 107,048,983 bp
  • T to C, chromosome 4 at 56,826,328 bp
  • T to A, chromosome 4 at 116,333,425 bp
  • A to T, chromosome 5 at 136,123,662 bp
  • C to A, chromosome 5 at 151,190,011 bp
  • G to A, chromosome 6 at 69,815,091 bp
  • C to T, chromosome 6 at 70,011,247 bp
  • T to A, chromosome 6 at 83,035,799 bp
  • T to A, chromosome 6 at 91,169,382 bp
  • T to C, chromosome 6 at 131,678,123 bp
  • A to T, chromosome 7 at 11,009,647 bp
  • T to C, chromosome 7 at 12,671,032 bp
  • T to C, chromosome 7 at 24,640,362 bp
  • G to A, chromosome 7 at 26,453,389 bp
  • A to G, chromosome 7 at 82,692,524 bp
  • A to G, chromosome 7 at 86,812,027 bp
  • T to C, chromosome 7 at 119,494,994 bp
  • C to T, chromosome 8 at 24,707,411 bp
  • T to A, chromosome 8 at 85,064,572 bp
  • A to T, chromosome 9 at 39,910,250 bp
  • A to T, chromosome 9 at 50,866,832 bp
  • T to A, chromosome 9 at 55,816,791 bp
  • C to T, chromosome 9 at 71,122,864 bp
  • A to G, chromosome 9 at 118,558,283 bp
  • A to G, chromosome 10 at 39,892,639 bp
  • C to T, chromosome 10 at 75,638,019 bp
  • A to G, chromosome 10 at 80,421,616 bp
  • T to A, chromosome 10 at 81,332,941 bp
  • T to A, chromosome 11 at 9,291,411 bp
  • A to G, chromosome 11 at 17,224,638 bp
  • A to T, chromosome 11 at 29,563,854 bp
  • T to A, chromosome 11 at 59,000,707 bp
  • C to T, chromosome 11 at 63,889,272 bp
  • A to C, chromosome 11 at 70,646,190 bp
  • C to T, chromosome 11 at 86,493,206 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • T to A, chromosome 11 at 101,559,538 bp
  • G to A, chromosome 11 at 101,771,456 bp
  • T to A, chromosome 12 at 101,149,285 bp
  • C to A, chromosome 12 at 104,314,926 bp
  • T to A, chromosome 12 at 117,721,326 bp
  • C to T, chromosome 13 at 41,103,515 bp
  • T to C, chromosome 13 at 49,102,800 bp
  • T to A, chromosome 13 at 54,726,695 bp
  • T to A, chromosome 13 at 56,548,341 bp
  • A to T, chromosome 14 at 32,904,569 bp
  • C to T, chromosome 14 at 89,897,239 bp
  • A to T, chromosome 15 at 34,838,922 bp
  • A to G, chromosome 15 at 55,059,939 bp
  • T to C, chromosome 15 at 99,470,836 bp
  • A to G, chromosome 15 at 102,116,907 bp
  • T to C, chromosome 16 at 4,119,772 bp
  • A to G, chromosome 16 at 15,664,233 bp
  • C to T, chromosome 16 at 18,272,768 bp
  • T to A, chromosome 16 at 49,296,866 bp
  • TGAAGAAGAA to TGAAGAA, chromosome 16 at 59,119,972 bp
  • A to G, chromosome 16 at 95,982,169 bp
  • C to T, chromosome 17 at 46,825,358 bp
  • TCACACA to TCACA, chromosome 17 at 56,270,629 bp
  • T to G, chromosome 17 at 94,874,339 bp
  • A to G, chromosome 18 at 62,936,956 bp
  • T to C, chromosome 19 at 5,747,544 bp
  • C to A, chromosome 19 at 5,869,450 bp
  • C to T, chromosome 19 at 6,853,835 bp
  • T to A, chromosome 19 at 11,461,242 bp
  • T to G, chromosome 19 at 13,585,508 bp
  • T to A, chromosome 19 at 46,856,995 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5771 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043371-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.