Strain Name:
C57BL/6J-MtgxR5775Btlr
Stock Number:
043374-MU
Citation ID:
RRID:MMRRC_043374-MU
Other Names:
R5775 (G1)
Major Collection:

Gene Information

Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: Jmjd2c, 2410141F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76804
Homologene: 41004
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b, aldosterone synthase, steroid-11-beta-hydroxylase, Cyp11b-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13072
Homologene: 128035
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16, 1110037D04Rik, Lrrc16a, Carmil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Sec24d
Name: Sec24 related gene family, member D (S. cerevisiae)
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69608
Homologene: 40986
Sec62
Name: SEC62 homolog (S. cerevisiae)
Synonyms: SEC62, Tloc1, HTP1, Dtrp1, 3100002M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69276
Homologene: 2449
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Atxn2
Name: ataxin 2
Synonyms: 9630045M23Rik, ATX2, Sca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20239
Homologene: 2234
Arpc2
Name: actin related protein 2/3 complex, subunit 2
Synonyms: 2210023N03Rik, p34-Arc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76709
HGNC: HGNC:705
Homologene: 4187
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: Wbp12, Bat-2, 3110039B05Rik, G2, Bat2, D17H6S51E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 53761
Homologene: 10567
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Traf3
Name: TNF receptor-associated factor 3
Synonyms: CD40bp, LAP1, CRAF1, CAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22031
Homologene: 7981
H2az1
Name: H2A.Z variant histone 1
Synonyms: H2A.Z, H2A.Z1, H2afz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51788
HGNC: HGNC:4741
Homologene: 80218
Cd63
Name: CD63 antigen
Synonyms: ME491, Tspan30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12512
VEGA: 10
HGNC: HGNC:1692
Homologene: 37526
Epha6
Name: Eph receptor A6
Synonyms: m-ehk2, Ehk2, Hek12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13840
Homologene: 56396
Pmm1
Name: phosphomannomutase 1
Synonyms: Secp53 (yeast) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29858
HGNC: HGNC:9114
Homologene: 90898
Pot1a
Name: protection of telomeres 1A
Synonyms: Pot1, 1500031H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101185
Homologene: 32263
Tubgcp3
Name: tubulin, gamma complex associated protein 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 259279
Homologene: 4609
Dennd6a
Name: DENN/MADD domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211922
Homologene: 13503
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56703
Homologene: 31761
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6, 1110007H17Rik, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 53867
Homologene: 9253
Kcns1
Name: K+ voltage-gated channel, subfamily S, 1
Synonyms: Kv9.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16538
HGNC: HGNC:6300
Homologene: 20517
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: heco, 1110008N23Rik, ELP79, A930030P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cav1.1, fmd, mdg, muscle dysgenesis, sj, DHPR alpha1s, Cchl1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 638695
Vps37a
Name: vacuolar protein sorting 37A
Synonyms: 2210018P21Rik, D8Ertd531e, 4930592A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52348
VEGA: 8
Homologene: 45120
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Foxh1
Name: forkhead box H1
Synonyms: Fast2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14106
VEGA: 15
HGNC: HGNC:3814
Homologene: 2914
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22253
Homologene: 2765
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: Obph1, ORP5, 1110006M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 79196
Homologene: 98024
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: SAMCAP3L, 1110017D07Rik, LNX4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239618
VEGA: 15
Homologene: 85433
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, uPARAP, Endo180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: C230004D03Rik, Rsbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229675
Homologene: 10154
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mt2, Mel1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Olfr889
Name: olfactory receptor 889
Synonyms: MOR162-2, GA_x6K02T2PVTD-31795028-31795957
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258475
Homologene: 138311
Pgpep1
Name: pyroglutamyl-peptidase I
Synonyms: 2810003H13Rik, Pcp, PGP-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66522
Homologene: 9793
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Sec61a2
Name: Sec61, alpha subunit 2 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57743
Homologene: 38481
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208151
Homologene: 28135
Olfr1173
Name: olfactory receptor 1173
Synonyms: MOR174-20_p, GA_x6K02T2Q125-49759783-49758845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404329
Homologene: 128091
Usp44
Name: ubiquitin specific peptidase 44
Synonyms: E430004F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327799
VEGA: 10
Homologene: 12961
Cd177
Name: CD177 antigen
Synonyms: 1190003K14Rik, Pdp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68891
Homologene: 49628
Tnip3
Name: TNFAIP3 interacting protein 3
Synonyms: 9030611K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 414084
Homologene: 47979
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66753
Homologene: 9247
Zfp354b
Name: zinc finger protein 354B
Synonyms: Kid2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27274
Homologene: 32187
Elovl1
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Synonyms: Ssc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54325
Homologene: 41322
AF067061
Name: cDNA sequence AF067061
Synonyms: clone L8 variable group of 2-cell-stage gene family, clone L4 variable group of 2-cell-stage gene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 236546
Wfikkn2
Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms: Gasp1, 2610304F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 278507
Homologene: 35284
Vmn2r-ps159
Name: vomeronasal 2, receptor, pseudogene 159
Synonyms: V2r8, Vmn2r-ps160, V2r9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Calm5
Name: calmodulin 5
Synonyms: Scarf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 494124
Esp3
Name: exocrine gland secreted peptide 3
Synonyms: Gm21945
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126766
VEGA: 17
Gm13998
Name: predicted gene 13998
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 101180908
Zfp987
Name: zinc finger protein 987
Synonyms: Gm13051, OTTMUSG00000010104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626316
Homologene: 133076
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,255,949 bp
  • G to T, chromosome 1 at 134,876,042 bp
  • T to C, chromosome 1 at 136,108,122 bp
  • A to T, chromosome 2 at 5,882,774 bp
  • A to T, chromosome 2 at 88,274,701 bp
  • G to T, chromosome 2 at 119,878,411 bp
  • A to C, chromosome 2 at 155,969,374 bp
  • T to C, chromosome 2 at 164,164,766 bp
  • A to G, chromosome 3 at 30,793,287 bp
  • A to T, chromosome 3 at 103,962,572 bp
  • C to T, chromosome 3 at 123,290,460 bp
  • T to C, chromosome 3 at 137,865,619 bp
  • A to G, chromosome 3 at 141,828,520 bp
  • T to C, chromosome 4 at 43,023,475 bp
  • C to A, chromosome 4 at 55,010,590 bp
  • T to G, chromosome 4 at 74,359,431 bp
  • G to A, chromosome 4 at 118,430,897 bp
  • T to G, chromosome 4 at 146,124,935 bp
  • G to T, chromosome 4 at 156,334,397 bp
  • C to T, chromosome 5 at 121,813,449 bp
  • T to A, chromosome 5 at 125,638,330 bp
  • A to T, chromosome 6 at 25,757,298 bp
  • A to G, chromosome 6 at 65,614,757 bp
  • T to C, chromosome 7 at 24,752,268 bp
  • A to C, chromosome 7 at 45,619,462 bp
  • A to T, chromosome 7 at 143,704,529 bp
  • A to T, chromosome 8 at 12,625,056 bp
  • A to G, chromosome 8 at 40,529,119 bp
  • G to A, chromosome 8 at 70,652,451 bp
  • G to A, chromosome 9 at 15,862,872 bp
  • G to T, chromosome 9 at 20,801,072 bp
  • A to T, chromosome 9 at 38,116,127 bp
  • C to T, chromosome 9 at 96,577,468 bp
  • A to G, chromosome 10 at 62,949,242 bp
  • A to G, chromosome 10 at 93,845,978 bp
  • T to A, chromosome 10 at 128,910,430 bp
  • A to T, chromosome 11 at 30,943,848 bp
  • A to T, chromosome 11 at 50,922,820 bp
  • G to T, chromosome 11 at 94,238,288 bp
  • G to A, chromosome 11 at 105,337,813 bp
  • A to T, chromosome 12 at 108,506,554 bp
  • A to G, chromosome 12 at 111,252,728 bp
  • A to G, chromosome 12 at 113,546,266 bp
  • T to C, chromosome 13 at 3,854,435 bp
  • T to C, chromosome 13 at 11,769,962 bp
  • T to C, chromosome 13 at 24,276,537 bp
  • T to A, chromosome 13 at 120,263,939 bp
  • T to A, chromosome 14 at 26,619,373 bp
  • C to T, chromosome 14 at 51,364,348 bp
  • A to G, chromosome 15 at 74,853,478 bp
  • G to A, chromosome 15 at 76,669,849 bp
  • A to T, chromosome 15 at 81,951,955 bp
  • A to T, chromosome 15 at 92,757,681 bp
  • C to T, chromosome 16 at 59,818,994 bp
  • T to C, chromosome 17 at 35,158,487 bp
  • T to A, chromosome 17 at 40,633,577 bp
  • C to A, chromosome 19 at 46,314,772 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5775 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043374-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.