Strain Name:
C57BL/6J-MtgxR5776Btlr
Stock Number:
043375-MU
Citation ID:
RRID:MMRRC_043375-MU
Other Names:
R5776 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Mov-13, Cola1, Cola-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Tln2
Name: talin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269424
Homologene: 18162
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52850
Homologene: 64485
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 214669
Homologene: 12882
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319817
Homologene: 28276
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1, ASTBDN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74838
Homologene: 14211
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: 9130026N02Rik, D19Bwg1430e, 4930528G08Rik, D19Ertd703e, Pp6r3, Pptcs3, Saps3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Stx16
Name: syntaxin 16
Synonyms: 5430410K23Rik, SYN16, 6330500A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228960
Homologene: 2791
Stip1
Name: stress-induced phosphoprotein 1
Synonyms: p60, IEF SSP 3521, Hop, Hsp70/Hsp90 organizing protein, STI1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20867
VEGA: 19
Homologene: 4965
Ppm1g
Name: protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
Synonyms: Fin13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14208
HGNC: HGNC:9278
Homologene: 31106
Oga
Name: O-GlcNAcase
Synonyms: Hy5, 5830447M11Rik, 4833427O07Rik, 2810009A20Rik, Mgea5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Erf
Name: Ets2 repressor factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13875
HGNC: HGNC:3444
Homologene: 68516
Fbxo9
Name: f-box protein 9
Synonyms: 9030401P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71538
Homologene: 8217
Sec22b
Name: SEC22 homolog B, vesicle trafficking protein
Synonyms: ERS-24, 4930564D15Rik, Sec22l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20333
Homologene: 3597
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381072
Homologene: 86807
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 634731
Homologene: 11204
Reg4
Name: regenerating islet-derived family, member 4
Synonyms: RELP, 2010002L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67709
Homologene: 41671
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: C730009O10Rik, 9430025M21Rik, lamellipodin, Lpd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77300
Homologene: 71030
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Or6k14
Name: olfactory receptor family 6 subfamily K member 14
Synonyms: GA_x6K02T2P20D-21075927-21074980, MOR105-9, MOR105-7, Olfr427
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259162
Homologene: 133035
Sctr
Name: secretin receptor
Synonyms: 6530402O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319229
Homologene: 68290
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Hcn3
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonyms: Hac3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15168
Homologene: 22453
Sox21
Name: SRY (sex determining region Y)-box 21
Synonyms: Sox25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223227
Homologene: 5143
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100121
Homologene: 8618
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Akr1c13
Name: aldo-keto reductase family 1, member C13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27384
Homologene: 121208
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 638695
Zfp641
Name: zinc finger protein 641
Synonyms: 9930016F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239652
VEGA: 15
Homologene: 17548
Igsf3
Name: immunoglobulin superfamily, member 3
Synonyms: 4833439O17Rik, 2810035F16Rik, 1700016K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 78908
HGNC: HGNC:5950
Homologene: 1182
Ctsj
Name: cathepsin J
Synonyms: rat gene/Cathepsin L-related protein, CatRLP, CATP, Cat P, Ctsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26898
VEGA: 13
HGNC: HGNC:2537
Homologene: 137246
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30956
Homologene: 4212
Extl1
Name: exostosin-like glycosyltransferase 1
Synonyms: D430033M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56219
HGNC: HGNC:3515
Homologene: 3277
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Gfer
Name: growth factor, augmenter of liver regeneration
Synonyms: ERV1, Alr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11692
VEGA: 17
HGNC: HGNC:4236
Homologene: 55884
Cfh
Name: complement component factor h
Synonyms: Sas-1, Mud-1, Sas1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12628
Homologene: 20086
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546913
Homologene: 84037
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329540
Homologene: 129589
Txndc15
Name: thioredoxin domain containing 15
Synonyms: 2310047H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69672
VEGA: 13
Homologene: 32594
Nipsnap1
Name: nipsnap homolog 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18082
HGNC: HGNC:7827
Homologene: 2695
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
Synonyms: Hpcl, 1600020H07Rik, Phyh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56794
Homologene: 5794
Slc38a3
Name: solute carrier family 38, member 3
Synonyms: 0610012J02Rik, D9Ucla2, Snat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76257
Homologene: 4983
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Or52z15
Name: olfactory receptor family 52 subfamily Z member 15
Synonyms: GA_x6K02T2PBJ9-6416276-6417237, MOR31-15P, Olfr625
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258169
Fdx2
Name: ferredoxin 2
Synonyms: B230118G17Rik, Fdx1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68165
VEGA: 9
Homologene: 31955
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622306
Homologene: 86127
Saraf
Name: store-operated calcium entry-associated regulatory factor
Synonyms: 1810045K07Rik, Tmem66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67887
Homologene: 9398
Hipk4
Name: homeodomain interacting protein kinase 4
Synonyms: LOC233020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233020
Homologene: 16970
Yjefn3
Name: YjeF N-terminal domain containing 3
Synonyms: LOC234365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234365
Gm15931
Name: predicted gene 15931
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 112136069
Trav6-4
Name: T cell receptor alpha variable 6-4
Synonyms: Gm13945
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100126463
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237890
Homologene: 19082
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,209,185 bp
  • T to C, chromosome 1 at 44,056,505 bp
  • G to A, chromosome 1 at 60,490,156 bp
  • T to C, chromosome 1 at 120,056,407 bp
  • C to A, chromosome 1 at 140,144,023 bp
  • A to T, chromosome 1 at 174,099,773 bp
  • A to G, chromosome 2 at 37,378,313 bp
  • T to G, chromosome 2 at 153,417,821 bp
  • G to A, chromosome 2 at 174,093,499 bp
  • A to G, chromosome 3 at 41,613,792 bp
  • A to C, chromosome 3 at 51,460,026 bp
  • C to T, chromosome 3 at 89,148,105 bp
  • A to T, chromosome 3 at 97,914,568 bp
  • T to A, chromosome 3 at 98,233,028 bp
  • G to A, chromosome 3 at 101,425,480 bp
  • T to A, chromosome 4 at 46,005,689 bp
  • T to C, chromosome 4 at 59,315,363 bp
  • A to C, chromosome 4 at 113,763,503 bp
  • T to C, chromosome 4 at 134,357,772 bp
  • T to C, chromosome 5 at 8,127,361 bp
  • T to C, chromosome 5 at 31,205,110 bp
  • T to A, chromosome 5 at 113,250,957 bp
  • T to A, chromosome 5 at 146,168,881 bp
  • A to T, chromosome 6 at 23,107,650 bp
  • A to T, chromosome 6 at 123,637,714 bp
  • A to T, chromosome 7 at 4,281,565 bp
  • T to C, chromosome 7 at 14,592,724 bp
  • T to C, chromosome 7 at 25,246,109 bp
  • T to C, chromosome 7 at 27,528,980 bp
  • T to A, chromosome 7 at 103,683,039 bp
  • T to A, chromosome 8 at 34,165,450 bp
  • A to T, chromosome 8 at 69,889,471 bp
  • C to A, chromosome 9 at 21,073,482 bp
  • C to T, chromosome 9 at 67,258,250 bp
  • T to C, chromosome 9 at 78,095,187 bp
  • C to A, chromosome 9 at 107,658,749 bp
  • T to A, chromosome 10 at 127,664,329 bp
  • T to A, chromosome 11 at 4,888,919 bp
  • C to T, chromosome 11 at 83,283,599 bp
  • C to T, chromosome 11 at 94,949,724 bp
  • C to T, chromosome 11 at 110,107,460 bp
  • A to T, chromosome 12 at 8,006,149 bp
  • T to A, chromosome 12 at 51,764,114 bp
  • T to C, chromosome 13 at 4,194,187 bp
  • A to G, chromosome 13 at 55,718,107 bp
  • A to G, chromosome 13 at 58,005,184 bp
  • T to C, chromosome 13 at 61,003,142 bp
  • A to T, chromosome 14 at 31,622,871 bp
  • C to T, chromosome 14 at 51,364,348 bp
  • A to G, chromosome 14 at 53,454,754 bp
  • A to G, chromosome 14 at 118,235,244 bp
  • G to A, chromosome 15 at 34,431,619 bp
  • T to C, chromosome 15 at 45,114,567 bp
  • A to G, chromosome 15 at 81,684,871 bp
  • T to C, chromosome 15 at 98,289,010 bp
  • A to G, chromosome 17 at 24,295,158 bp
  • G to T, chromosome 17 at 24,696,053 bp
  • T to C, chromosome 17 at 56,104,983 bp
  • A to G, chromosome 19 at 3,526,901 bp
  • A to G, chromosome 19 at 7,022,025 bp
  • T to C, chromosome 19 at 45,771,924 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5776 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043375-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.