Strain Name:
C57BL/6J-MtgxR5778Btlr
Stock Number:
043376-MU
Citation ID:
RRID:MMRRC_043376-MU
Other Names:
R5778 (G1)
Major Collection:

Gene Information

Eno2
Name: enolase 2, gamma neuronal
Synonyms: D6Ertd375e, Eno-2, NSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, mDomino, p400
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75560
Homologene: 38779
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18193
VEGA: 13
Homologene: 32543
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66860
Homologene: 18946
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 2310004H21Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72313
Homologene: 103956
Dusp16
Name: dual specificity phosphatase 16
Synonyms: MKP7, D6Ertd213e, 3830417M17Rik, MKP-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70686
Homologene: 15604
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Prom1
Name: prominin 1
Synonyms: Prom-1, 4932416E19Rik, AC133, Prom, CD133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Ubqln1
Name: ubiquilin 1
Synonyms: 1810030E05Rik, DA41, Dsk2, D13Ertd372e, XDRP1, Plic-1, 1110046H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56085
VEGA: 13
Homologene: 137258
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223435
VEGA: 15
Homologene: 20847
B3gnt3
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Synonyms: 2210008L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72297
Homologene: 113516
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, 3110031A07Rik, A630018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76800
Homologene: 35425
Caprin2
Name: caprin family member 2
Synonyms: RNG140, Eeg1, C1qdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232560
Homologene: 11393
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, Apn, aminopeptidase N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Acta1
Name: actin, alpha 1, skeletal muscle
Synonyms: Actsk-1, Acts
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11459
HGNC: HGNC:129
Homologene: 121702
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Spdye4b
Name: speedy/RINGO cell cycle regulator family, member E4B
Synonyms: 4933411G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330228
Homologene: 138445
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, crash, Adgrc1, Crsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 70363
VEGA: 15
Homologene: 66605
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: AIB3, RAP250, PRIP, NRC, ASC2, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56406
Homologene: 137337
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319555
Homologene: 72261
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242274
Homologene: 10817
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 434341
Homologene: 88935
Mmp12
Name: matrix metallopeptidase 12
Synonyms: Mmel, MMP12, macrophage elastase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17381
HGNC: HGNC:7158
Homologene: 20547
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: Sdccag33, NY-CO-33, teashirt1, Tsh1, 5730407I04Rik, D18Bwg1409e, Mtsh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 110796
Homologene: 4227
Metrnl
Name: meteorin, glial cell differentiation regulator-like
Synonyms: 9430048M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 210029
Homologene: 16993
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Klhdc7b
Name: kelch domain containing 7B
Synonyms: EG546648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 546648
Homologene: 34707
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19731
Homologene: 9039
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: Nepas, bHLHe17, MOP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 53417
Homologene: 9646
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: SAPLT, 1700056N23Rik, 1700042F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67331
VEGA: 10
Homologene: 19034
Krt8
Name: keratin 8
Synonyms: Card2, EndoA, cytokeratin 8, cytokeratin8, K8, Krt-2.8, cytokeratin-8, Krt2-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16691
VEGA: 15
HGNC: HGNC:6446
Homologene: 55643
Cdh15
Name: cadherin 15
Synonyms: Mcad, Cdh14, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Iltifb
Name: interleukin 10-related T cell-derived inducible factor beta
Synonyms: Il22b, IL-TIFb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 116849
Homologene: 9669
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 625605
Homologene: 113703
Vmn1r189
Name: vomeronasal 1 receptor 189
Synonyms: V1rh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 252906
Homologene: 110880
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: 0610010C24Rik, ASM3A, ASML3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 57319
Homologene: 4886
Mpp2
Name: membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms: Dlgh2, Pals4, Dlg2, D11Bwg0652e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 50997
HGNC: HGNC:7220
Homologene: 3920
Tafa3
Name: TAFA chemokine like family member 3
Synonyms: 7530404M11Rik, Sam3, Tafa3, Fam19a3, Tafa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329731
Homologene: 18811
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230868
Homologene: 13153
Olfr77
Name: olfactory receptor 77
Synonyms: 18A, GA_x6K02T2PVTD-13660026-13660964, MOR143-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258336
Homologene: 133688
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: Prlpf, PLP-F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19114
Homologene: 49263
Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Synonyms: Fc gamma RIIB, Ly-17, LyM-1, FcgRII, Fc[g]RII, FcgammaRIIB, Fcgr2a, Fcr-3, Ly-m20, Fcr-2, Fcgr2, F630109E10Rik, CD32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14130
HGNC: HGNC:3618
Homologene: 2974
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: Lppr3, BC005764
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216152
Homologene: 11769
Fam221b
Name: family with sequence similarity 221, member B
Synonyms: 4930412F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242408
Homologene: 52184
Galm
Name: galactose mutarotase
Synonyms: aldose 1-epimerase, A530057M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 319625
Homologene: 71795
Gsg1
Name: germ cell associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14840
Homologene: 7745
Olfr1167
Name: olfactory receptor 1167
Synonyms: MOR174-16, GA_x6K02T2Q125-49641892-49640942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258291
Homologene: 138307
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 245867
Homologene: 10099
Ighv1-20
Name: immunoglobulin heavy variable V1-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 668497
Ighv1-11
Name: immunoglobulin heavy variable V1-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 629859
Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
Xrcc6bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
0610007P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
BC026585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 105,591,722 bp
  • G to T, chromosome 1 at 152,552,421 bp
  • A to T, chromosome 1 at 157,161,290 bp
  • T to G, chromosome 1 at 157,470,787 bp
  • C to T, chromosome 1 at 170,963,388 bp
  • G to T, chromosome 2 at 59,699,347 bp
  • T to A, chromosome 2 at 88,149,617 bp
  • T to C, chromosome 2 at 155,406,768 bp
  • A to C, chromosome 2 at 181,855,198 bp
  • A to T, chromosome 3 at 36,958,714 bp
  • T to A, chromosome 3 at 104,772,189 bp
  • A to G, chromosome 3 at 158,170,743 bp
  • A to G, chromosome 4 at 43,660,683 bp
  • C to T, chromosome 4 at 140,037,521 bp
  • A to T, chromosome 5 at 44,007,047 bp
  • A to T, chromosome 5 at 73,072,778 bp
  • T to C, chromosome 5 at 110,719,584 bp
  • G to A, chromosome 5 at 143,202,387 bp
  • A to T, chromosome 5 at 143,719,576 bp
  • A to T, chromosome 6 at 124,766,298 bp
  • G to T, chromosome 6 at 134,718,314 bp
  • A to T, chromosome 6 at 135,244,350 bp
  • A to T, chromosome 6 at 148,869,322 bp
  • A to T, chromosome 7 at 9,976,347 bp
  • A to T, chromosome 7 at 17,051,984 bp
  • C to G, chromosome 7 at 28,994,221 bp
  • T to C, chromosome 7 at 79,836,391 bp
  • T to C, chromosome 8 at 25,659,818 bp
  • T to C, chromosome 8 at 71,692,938 bp
  • T to A, chromosome 8 at 72,693,117 bp
  • A to G, chromosome 8 at 94,479,526 bp
  • G to A, chromosome 8 at 122,856,587 bp
  • A to G, chromosome 8 at 123,892,125 bp
  • T to A, chromosome 9 at 7,350,106 bp
  • G to T, chromosome 9 at 19,921,041 bp
  • C to A, chromosome 10 at 57,801,001 bp
  • A to G, chromosome 10 at 79,866,503 bp
  • A to G, chromosome 10 at 80,520,173 bp
  • C to A, chromosome 10 at 118,294,863 bp
  • A to G, chromosome 10 at 126,899,582 bp
  • G to A, chromosome 11 at 101,525,301 bp
  • A to T, chromosome 11 at 102,064,443 bp
  • A to T, chromosome 11 at 121,714,738 bp
  • T to A, chromosome 12 at 8,015,074 bp
  • T to C, chromosome 12 at 85,819,480 bp
  • A to T, chromosome 12 at 114,612,431 bp
  • C to A, chromosome 12 at 114,723,877 bp
  • A to G, chromosome 13 at 22,102,382 bp
  • C to T, chromosome 13 at 27,661,000 bp
  • T to A, chromosome 13 at 55,306,979 bp
  • C to T, chromosome 13 at 58,183,317 bp
  • T to C, chromosome 14 at 79,770,757 bp
  • A to G, chromosome 15 at 27,856,164 bp
  • T to A, chromosome 15 at 71,479,032 bp
  • A to T, chromosome 15 at 86,032,955 bp
  • A to T, chromosome 15 at 89,387,320 bp
  • T to C, chromosome 15 at 102,003,939 bp
  • T to A, chromosome 17 at 80,127,717 bp
  • A to T, chromosome 18 at 20,409,222 bp
  • T to A, chromosome 18 at 84,015,680 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5778 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043376-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.