Strain Name:
C57BL/6J-MtgxR5784Btlr
Stock Number:
043381-MU
Citation ID:
RRID:MMRRC_043381-MU
Other Names:
R5784 (G1)
Major Collection:

Gene Information

Mafb
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
Synonyms: Krml1, Krml, Kreisler
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16658
HGNC: HGNC:6408
Homologene: 31315
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: BTF2, D5Ertd679e, 5033417D07Rik, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Lars
Name: leucyl-tRNA synthetase
Synonyms: 2310045K21Rik, 3110009L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20527
Homologene: 74302
Dhx38
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 38
Synonyms: Prp16, Ddx38, 5730550P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 64340
Homologene: 8512
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, 9430077C05Rik, Etl-4, Skt, E330027G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 208618
Homologene: 10477
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78455
Homologene: 8918
Rnf121
Name: ring finger protein 121
Synonyms: 4930544L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75212
Homologene: 10132
Traf2
Name: TNF receptor-associated factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22030
Homologene: 22520
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: 2810036I15Rik, RIM2, Syt3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 116838
VEGA: 15
Homologene: 81639
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: 2610301F02Rik, CAMDI, ENSMUSG00000075261
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545428
Homologene: 52149
Grin2c
Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Synonyms: GluRepsilon3, NR2C, NMDAR2C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14813
HGNC: HGNC:4587
Homologene: 647
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231128
Homologene: 2746
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, A930005E13Rik, 1810009A16Rik, LOC381562, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69116
Homologene: 10804
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72128
Homologene: 86705
Map1s
Name: microtubule-associated protein 1S
Synonyms: Bpy2ip1, 6430517J16Rik, Mtap1s, Map8, VCY2IP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270058
Homologene: 10047
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 170721
Homologene: 71541
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Lulu2, 6430543G08Rik, Epb4.1l4b, Ehm2, D4Ertd346e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54357
Homologene: 69270
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, alpha myosin, Myhca, alpha cardiac MHC, A830009F23Rik, Myhc-a, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Casp1
Name: caspase 1
Synonyms: Caspase-1, interleukin 1 beta-converting enzyme, ICE, Il1bc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12362
VEGA: 9
HGNC: HGNC:1499
Homologene: 133272
Hdhd2
Name: haloacid dehalogenase-like hydrolase domain containing 2
Synonyms: 3110052N05Rik, 0610039H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 76987
Homologene: 12667
Pcdh10
Name: protocadherin 10
Synonyms: 6430521D13Rik, OL-pc, 6430703F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18526
Homologene: 74967
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Npr2
Name: natriuretic peptide receptor 2
Synonyms: guanylyl cyclase-B, cn, pwe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
Homologene: 11279
Aox3
Name: aldehyde oxidase 3
Synonyms: 1200011D03Rik, AOH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71724
Homologene: 90899
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Mppe1
Name: metallophosphoesterase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225651
VEGA: 18
Homologene: 41512
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 319800
Homologene: 77136
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 329015
Homologene: 86985
Trim43c
Name: tripartite motif-containing 43C
Synonyms: Trim43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 666731
Homologene: 105432
Olfr1497
Name: olfactory receptor 1497
Synonyms: MOR212-1, GA_x6K02T2RE5P-4127765-4126821
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258736
Homologene: 17373
Zfp422
Name: zinc finger protein 422
Synonyms: KOX15, Krox25, Krox-25-2, Krox26, Krox-26, 2900028O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67255
Homologene: 5067
Wdr27
Name: WD repeat domain 27
Synonyms: 0610012K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71682
VEGA: 17
Homologene: 18417
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231858
Homologene: 77648
Olfr309
Name: olfactory receptor 309
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258196
Homologene: 47595
Olfr248
Name: olfactory receptor 248
Synonyms: GA_x6K02T2MFC0-1145-1312, MOR267-7, Olfr415, GA_x6K02T2P20D-20771141-20770212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 258709
Dpep3
Name: dipeptidase 3
Synonyms: 1700018F16Rik, MBD-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71854
Homologene: 23357
Ltk
Name: leukocyte tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17005
HGNC: HGNC:6721
Homologene: 130502
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 385674
Homologene: 55755
Rbfox1
Name: RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms: FOX1, HRNBP1, A2bp, A2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268859
VEGA: 16
Homologene: 69339
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 210035
Homologene: 18346
Saxo2
Name: stabilizer of axonemal microtubules 2
Synonyms: 1700129I04Rik, Fam154b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330577
Homologene: 25135
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 4921517L17Rik, 5430421B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70873
Homologene: 15440
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100101919
Homologene: 41287
Cnep1r1
Name: CTD nuclear envelope phosphatase 1 regulatory subunit 1
Synonyms: 5033428A16Rik, Tmem188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382030
Homologene: 14472
4932416K20Rik
Name: RIKEN cDNA 4932416K20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 442809
Homologene: 133775
Mydgf
Name: myeloid derived growth factor
Synonyms: D17Wsu104e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 28106
Homologene: 10425
Gm8332
Name: predicted pseudogene 8332
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 666862
VEGA: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,524,068 bp
  • A to G, chromosome 1 at 58,153,499 bp
  • G to A, chromosome 1 at 174,391,399 bp
  • A to G, chromosome 2 at 20,806,205 bp
  • A to T, chromosome 2 at 25,539,037 bp
  • A to C, chromosome 2 at 77,029,327 bp
  • G to A, chromosome 2 at 119,754,359 bp
  • A to G, chromosome 2 at 130,279,671 bp
  • A to G, chromosome 2 at 156,338,657 bp
  • A to T, chromosome 2 at 160,366,541 bp
  • A to G, chromosome 3 at 19,264,845 bp
  • T to G, chromosome 3 at 45,380,640 bp
  • A to G, chromosome 4 at 43,632,801 bp
  • A to C, chromosome 4 at 57,086,003 bp
  • C to G, chromosome 4 at 139,425,218 bp
  • T to C, chromosome 5 at 34,466,223 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • G to T, chromosome 5 at 142,487,513 bp
  • A to T, chromosome 6 at 116,626,810 bp
  • A to T, chromosome 6 at 122,735,417 bp
  • C to T, chromosome 7 at 82,634,874 bp
  • T to C, chromosome 7 at 86,306,535 bp
  • A to G, chromosome 7 at 102,035,376 bp
  • T to C, chromosome 8 at 70,914,358 bp
  • G to T, chromosome 8 at 71,655,666 bp
  • T to A, chromosome 8 at 88,130,726 bp
  • T to A, chromosome 8 at 104,797,629 bp
  • T to C, chromosome 8 at 105,978,743 bp
  • G to T, chromosome 8 at 109,559,613 bp
  • T to C, chromosome 9 at 5,299,337 bp
  • A to T, chromosome 9 at 88,847,643 bp
  • T to C, chromosome 10 at 79,067,607 bp
  • T to A, chromosome 10 at 127,677,198 bp
  • T to A, chromosome 11 at 107,670,481 bp
  • T to C, chromosome 11 at 115,258,295 bp
  • A to G, chromosome 12 at 83,781,980 bp
  • A to G, chromosome 12 at 84,868,739 bp
  • T to A, chromosome 12 at 88,249,755 bp
  • T to C, chromosome 14 at 54,953,064 bp
  • T to G, chromosome 15 at 39,535,987 bp
  • A to T, chromosome 16 at 3,854,574 bp
  • A to T, chromosome 16 at 7,224,339 bp
  • A to G, chromosome 16 at 21,898,641 bp
  • T to A, chromosome 17 at 14,926,233 bp
  • T to C, chromosome 17 at 56,178,254 bp
  • T to C, chromosome 18 at 42,219,899 bp
  • T to C, chromosome 18 at 67,228,027 bp
  • A to T, chromosome 18 at 76,967,145 bp
  • C to A, chromosome 19 at 6,261,505 bp
  • G to A, chromosome 19 at 8,344,393 bp
  • A to T, chromosome 19 at 13,795,346 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043381-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.