Strain Name:
C57BL/6J-MtgxR5801Btlr/Mmmh
Stock Number:
043390-MU
Citation ID:
RRID:MMRRC_043390-MU
Other Names:
R5801 (G1)
Major Collection:

Strain Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: LCB2, Spt2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20773
Homologene: 21610
Ddx55
Name: DEAD box helicase 55
Synonyms: 2810021H22Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: argonaute 3, eIF2C3, C130014L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214150
Homologene: 49799
Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
Synonyms: C130030P16Rik, 8430414L16Rik, Hrpt2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214498
Homologene: 11571
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Mapk1ip1
Name: mitogen-activated protein kinase 1 interacting protein 1
Synonyms: Miss, 2310009E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69546
Homologene: 75251
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Cpsf7
Name: cleavage and polyadenylation specific factor 7
Synonyms: C330017N18Rik, 5730453I16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269061
VEGA: 19
Homologene: 11731
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
Erc1
Name: ELKS/RAB6-interacting/CAST family member 1
Synonyms: RAB6IP2B, RAB6IP2A, 5033405M01Rik, B430107L16Rik, 9630025C19Rik, Rab6ip2, Elks1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 111173
Homologene: 14229
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 383435
Homologene: 138453
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, Tex190, 9430095H01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Slc35e3
Name: solute carrier family 35, member E3
Synonyms: 9330166G04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215436
VEGA: 10
Homologene: 41279
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Adam15
Name: ADAM metallopeptidase domain 15
Synonyms: metargidin, MDC15
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11490
HGNC: HGNC:193
Homologene: 2829
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546849
Homologene: 82586
Alx3
Name: aristaless-like homeobox 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11694
HGNC: HGNC:449
Homologene: 4737
Stk10
Name: serine/threonine kinase 10
Synonyms: Lok, Gek1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20868
Homologene: 38122
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Ertd410e, D19Wsu12e, b2b2633Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226090
Homologene: 121891
Eif2b1
Name: eukaryotic translation initiation factor 2B, subunit alpha
Synonyms: EIF2BA, EIF2B, 26kDa, D5Ertd406e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209354
HGNC: HGNC:3257
Homologene: 1080
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Thbs2
Name: thrombospondin 2
Synonyms: TSP2, Thbs-2, Thrombospondin-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243274
Homologene: 71684
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330369
Homologene: 19837
Caskin2
Name: CASK-interacting protein 2
Synonyms: 1600028L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140721
Homologene: 32485
Edn1
Name: endothelin 1
Synonyms: ET-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13614
VEGA: 13
HGNC: HGNC:3176
Homologene: 1476
Tsfm
Name: Ts translation elongation factor, mitochondrial
Synonyms: 9430024O13Rik, EF-Tsmt, EF-TS, 2310050B20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66399
Homologene: 4184
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Dpy19l3
Name: dpy-19 like C-mannosyltransferase 3
Synonyms: 9330164H19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233115
Homologene: 18692
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, 6330569M22Rik, Fam40a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229707
Homologene: 35064
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Zfp109
Name: zinc finger protein 109
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56869
Rasgef1c
Name: RasGEF domain family, member 1C
Synonyms: 9130006A14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74563
Homologene: 17918
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Mrpl9
Name: mitochondrial ribosomal protein L9
Synonyms: C330013D18Rik, 8030480E20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78523
Homologene: 12696
Or1e1f
Name: olfactory receptor family 1 subfamily E member 1F
Synonyms: GA_x6K02T2P1NL-4121434-4122381, MOR135-28, Olfr397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258343
Homologene: 138309
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74419
Homologene: 69456
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Rpusd4
Name: RNA pseudouridylate synthase domain containing 4
Synonyms: 2410001E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71989
Homologene: 32794
Tacr1
Name: tachykinin receptor 1
Synonyms: neurokinin receptor 1, NK-1R, NK1-R, NK1 receptor, Tac1r, substance p receptor, SPr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21336
Homologene: 20288
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: 9130206P09Rik, RIP11, GAF1, D6Ertd32e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52055
Homologene: 9158
Prickle4
Name: prickle planar cell polarity protein 4
Synonyms: LOC381104
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381104
Homologene: 22752
Nkain2
Name: Na+/K+ transporting ATPase interacting 2
Synonyms: 6330571D19Rik, Tcba1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432450
Homologene: 65073
Cuedc2
Name: CUE domain containing 2
Synonyms: 3010002G01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67116
VEGA: 19
Homologene: 11430
Ociad2
Name: OCIA domain containing 2
Synonyms: 1810027I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433904
Homologene: 78179
Gm6505
Name: predicted pseudogene 6505
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 624446
Imp3
Name: IMP3, U3 small nucleolar ribonucleoprotein
Synonyms: Imp3, 1190002L16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102462
Homologene: 6120
Ighv1-18
Name: immunoglobulin heavy variable V1-18
Synonyms: Gm16856
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,898,078 bp
  • T to C, chromosome 1 at 45,389,481 bp
  • T to C, chromosome 1 at 96,872,084 bp
  • C to T, chromosome 1 at 96,947,631 bp
  • T to A, chromosome 1 at 139,039,989 bp
  • T to A, chromosome 1 at 143,608,543 bp
  • T to C, chromosome 2 at 11,769,826 bp
  • A to G, chromosome 2 at 30,030,601 bp
  • A to G, chromosome 2 at 143,989,783 bp
  • A to G, chromosome 2 at 177,473,358 bp
  • A to T, chromosome 3 at 28,764,967 bp
  • A to T, chromosome 3 at 89,224,397 bp
  • C to T, chromosome 3 at 89,342,361 bp
  • T to C, chromosome 3 at 94,447,796 bp
  • T to A, chromosome 3 at 107,604,941 bp
  • A to C, chromosome 3 at 107,621,441 bp
  • A to T, chromosome 4 at 126,371,768 bp
  • T to A, chromosome 4 at 144,703,636 bp
  • T to C, chromosome 5 at 36,604,569 bp
  • A to G, chromosome 5 at 73,326,299 bp
  • A to G, chromosome 5 at 76,630,676 bp
  • A to G, chromosome 5 at 84,331,226 bp
  • T to C, chromosome 5 at 124,566,497 bp
  • T to C, chromosome 5 at 124,574,712 bp
  • A to G, chromosome 5 at 127,784,900 bp
  • T to C, chromosome 6 at 24,449,769 bp
  • T to A, chromosome 6 at 82,557,153 bp
  • T to A, chromosome 6 at 85,337,600 bp
  • G to T, chromosome 6 at 85,484,533 bp
  • T to A, chromosome 6 at 119,773,822 bp
  • T to C, chromosome 7 at 24,228,701 bp
  • G to A, chromosome 7 at 25,271,438 bp
  • T to C, chromosome 7 at 35,725,298 bp
  • G to A, chromosome 7 at 44,356,816 bp
  • A to T, chromosome 7 at 83,622,478 bp
  • T to A, chromosome 7 at 138,836,510 bp
  • C to A, chromosome 8 at 66,513,647 bp
  • A to G, chromosome 8 at 87,859,362 bp
  • A to G, chromosome 9 at 32,255,788 bp
  • A to G, chromosome 9 at 35,270,073 bp
  • A to G, chromosome 9 at 56,937,802 bp
  • A to T, chromosome 9 at 60,602,633 bp
  • A to G, chromosome 9 at 105,948,367 bp
  • C to T, chromosome 9 at 108,113,009 bp
  • A to G, chromosome 9 at 119,172,083 bp
  • T to C, chromosome 10 at 32,402,268 bp
  • T to C, chromosome 10 at 61,202,996 bp
  • T to A, chromosome 10 at 117,745,862 bp
  • TCACTCC to TCACTCCACTCC, chromosome 10 at 127,022,837 bp
  • C to T, chromosome 11 at 32,596,748 bp
  • T to C, chromosome 11 at 42,421,389 bp
  • T to G, chromosome 11 at 49,970,056 bp
  • T to C, chromosome 11 at 73,964,946 bp
  • T to C, chromosome 11 at 115,803,473 bp
  • A to G, chromosome 12 at 9,006,723 bp
  • T to C, chromosome 12 at 87,341,771 bp
  • A to G, chromosome 12 at 102,573,945 bp
  • T to A, chromosome 12 at 114,682,708 bp
  • C to A, chromosome 13 at 42,306,806 bp
  • T to A, chromosome 13 at 96,483,586 bp
  • C to A, chromosome 15 at 94,347,670 bp
  • A to G, chromosome 16 at 20,654,922 bp
  • A to T, chromosome 17 at 14,687,863 bp
  • C to A, chromosome 17 at 47,688,773 bp
  • T to C, chromosome 17 at 56,563,103 bp
  • A to T, chromosome 19 at 10,539,632 bp
  • A to G, chromosome 19 at 11,301,786 bp
  • A to T, chromosome 19 at 11,301,882 bp
  • A to G, chromosome 19 at 29,612,828 bp
  • T to C, chromosome 19 at 46,331,357 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5801 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043390-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.