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Strain Name:
C57BL/6J-MtgxR5807Btlr/Mmmh
Stock Number:
043393-MU
Citation ID:
RRID:MMRRC_043393-MU
Other Names:
R5807 (G1)
Major Collection:

Strain Information

Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Synonyms: Acra7, alpha7, alpha7 nicotinic receptor, alpha7-nAChR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11441
Homologene: 593
Gcg
Name: glucagon
Synonyms: GLP-1, glucagon-like peptide I, Glu, PPG
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14526
HGNC: HGNC:4191
Homologene: 1553
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 33,480,406 bp
  • A to G, chromosome 1 at 34,807,615 bp
  • A to G, chromosome 1 at 71,303,492 bp
  • T to C, chromosome 1 at 71,648,059 bp
  • T to C, chromosome 1 at 130,811,526 bp
  • C to T, chromosome 1 at 159,886,930 bp
  • A to G, chromosome 1 at 171,775,062 bp
  • C to T, chromosome 2 at 60,428,721 bp
  • A to G, chromosome 2 at 62,475,725 bp
  • A to G, chromosome 2 at 76,584,513 bp
  • G to T, chromosome 2 at 118,388,851 bp
  • G to A, chromosome 2 at 168,653,534 bp
  • T to A, chromosome 3 at 20,263,742 bp
  • T to C, chromosome 3 at 35,812,279 bp
  • C to A, chromosome 3 at 95,410,654 bp
  • C to A, chromosome 4 at 43,820,912 bp
  • T to A, chromosome 4 at 107,568,082 bp
  • A to G, chromosome 4 at 135,917,436 bp
  • A to G, chromosome 4 at 141,623,662 bp
  • T to C, chromosome 5 at 97,063,494 bp
  • A to G, chromosome 5 at 117,976,868 bp
  • T to A, chromosome 6 at 8,158,144 bp
  • T to C, chromosome 6 at 124,724,984 bp
  • G to T, chromosome 7 at 19,143,207 bp
  • A to G, chromosome 7 at 48,643,362 bp
  • T to A, chromosome 7 at 56,230,919 bp
  • T to A, chromosome 7 at 63,148,601 bp
  • C to T, chromosome 7 at 102,724,202 bp
  • T to A, chromosome 7 at 106,330,223 bp
  • TCCCC to TCCC, chromosome 7 at 110,124,569 bp
  • A to G, chromosome 7 at 119,500,543 bp
  • C to T, chromosome 8 at 25,849,714 bp
  • A to G, chromosome 8 at 72,580,100 bp
  • A to G, chromosome 9 at 15,332,532 bp
  • A to G, chromosome 9 at 39,614,463 bp
  • A to G, chromosome 9 at 118,527,130 bp
  • A to G, chromosome 10 at 18,647,798 bp
  • A to G, chromosome 10 at 122,449,471 bp
  • C to A, chromosome 10 at 127,357,542 bp
  • G to A, chromosome 10 at 128,088,562 bp
  • T to C, chromosome 11 at 8,493,211 bp
  • T to C, chromosome 11 at 59,079,650 bp
  • C to A, chromosome 11 at 78,022,426 bp
  • T to G, chromosome 11 at 83,949,682 bp
  • T to A, chromosome 11 at 99,949,069 bp
  • A to G, chromosome 12 at 86,514,401 bp
  • T to C, chromosome 12 at 111,485,739 bp
  • G to A, chromosome 12 at 112,852,796 bp
  • A to T, chromosome 13 at 73,327,434 bp
  • T to A, chromosome 14 at 51,101,429 bp
  • A to G, chromosome 14 at 51,145,450 bp
  • T to A, chromosome 14 at 55,785,298 bp
  • C to A, chromosome 15 at 58,590,550 bp
  • T to C, chromosome 15 at 81,843,453 bp
  • T to A, chromosome 15 at 101,530,212 bp
  • A to T, chromosome 16 at 14,916,972 bp
  • T to A, chromosome 17 at 23,387,307 bp
  • T to C, chromosome 17 at 46,677,465 bp
  • C to A, chromosome 17 at 84,672,291 bp
  • T to A, chromosome 19 at 7,456,827 bp
  • T to C, chromosome 19 at 40,113,500 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5807 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043393-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.