Strain Name:
C57BL/6J-MtgxR5821Btlr
Stock Number:
043401-MU
Citation ID:
RRID:MMRRC_043401-MU
Other Names:
R5821 (G1)
Major Collection:

Gene Information

Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227723
Homologene: 106649
Clasp1
Name: CLIP associating protein 1
Synonyms: CLASP1, B130045P17Rik, CLASP1alpha, mCLASP1, 1700030C23Rik, 5730583A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Cers2
Name: ceramide synthase 2
Synonyms: Trh3, 0610013I17Rik, Lass2, CerS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76893
Homologene: 39581
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: Myst1, 2010203C02Rik, D7Ertd629e, 5830450F21Rik, MOF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67773
Homologene: 41676
Kif16b
Name: kinesin family member 16B
Synonyms: 8430434E15Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16558
Homologene: 135708
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: G1-448-15, repro12, mei2-5, 5730481H23Rik, AKAP450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Kif18a
Name: kinesin family member 18A
Synonyms: B130001M12Rik, gcd2, N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228421
Homologene: 41820
Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Synonyms: SF1, adrenal 4-binding protein, SF-1, ELP, Ftzf1, Ad4BP, Ftz-F1, steroidogenic factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26423
HGNC: HGNC:7983
Homologene: 3638
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, D630001M17Rik, 9330188B09Rik, LOC381026, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: 2810021A19Rik, CIR, 1700023B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66935
Homologene: 3589
M1ap
Name: meiosis 1 associated protein
Synonyms: D6Mm5e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110958
Homologene: 13210
Slmap
Name: sarcolemma associated protein
Synonyms: Miranda, Slap, D330001L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 83997
Homologene: 31428
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 4930467B06Rik, 0610016I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Synonyms: I-kappaBalpha, Nfkbi, I(Kappa)B(alpha), IkappaBalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18035
VEGA: 12
HGNC: HGNC:7797
Homologene: 7863
Ighd
Name: immunoglobulin heavy constant delta
Synonyms: IgD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380797
Nutm2
Name: NUT family member 2
Synonyms: LOC328250, Gm806
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328250
Homologene: 128615
Epha5
Name: Eph receptor A5
Synonyms: Els1, Cek7, Ehk1, Hek7, Rek7, bsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Ciita
Name: class II transactivator
Synonyms: Gm9475, C2ta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12265
VEGA: 16
HGNC: HGNC:7067
Homologene: 207
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: Nec2, PC2, Nec-2, prohormone convertase 2, SPC2, Phpp-2, 6330411F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nax, 1110034K09Rik, NaG, Nav2, Nav2.3, Scn6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: Pde5, PDE5A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214642
Homologene: 57014
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330485
Homologene: 18333
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243043
Homologene: 18464
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217356
Homologene: 45126
Krt82
Name: keratin 82
Synonyms: Krt2-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 114566
VEGA: 15
HGNC: HGNC:6459
Homologene: 13200
Ing2
Name: inhibitor of growth family, member 2
Synonyms: Ing1l, 2810011M06Rik, P33ING2, ING2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69260
HGNC: HGNC:6063
Homologene: 20388
Ro60
Name: Ro60, Y RNA binding protein
Synonyms: A530054J02Rik, 1810007I17Rik, Ssa2, Ssa, Trove2, SS-A/Ro
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20822
Homologene: 3383
Cfap161
Name: cilia and flagella associated protein 161
Synonyms: 1700026D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75556
Homologene: 12605
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240084
Homologene: 10396
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: TG C, tTG, G[a]h, tTGas, TGase2, protein-glutamine gamma-glutamyltransferase, TG2, tissue transglutaminase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21817
Homologene: 3391
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: 0610006A03Rik, Afuc, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 194126
Homologene: 82382
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nep2, NEPLP alpha, Mell1, NEPLP gamma, SEP, NEPLP beta, Nl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Galnt2l
Name: polypeptide N-acetylgalactosaminyltransferase 2-like
Synonyms: Gm20388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
1700001O22Rik
Name: RIKEN cDNA 1700001O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73598
Homologene: 18859
Smim8
Name: small integral membrane protein 8
Synonyms: 2810406B13Rik, 1810030N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66291
Homologene: 10708
Gm26796
Name: predicted gene, 26796
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,142,132 bp
  • A to G, chromosome 1 at 105,589,063 bp
  • T to A, chromosome 1 at 118,590,484 bp
  • A to G, chromosome 1 at 143,766,765 bp
  • A to T, chromosome 2 at 30,796,446 bp
  • A to T, chromosome 2 at 32,212,132 bp
  • A to T, chromosome 2 at 38,708,499 bp
  • T to C, chromosome 2 at 66,743,703 bp
  • C to T, chromosome 2 at 73,312,460 bp
  • G to A, chromosome 2 at 109,289,845 bp
  • T to C, chromosome 2 at 142,702,666 bp
  • T to A, chromosome 2 at 143,749,115 bp
  • T to A, chromosome 2 at 158,143,054 bp
  • G to A, chromosome 3 at 95,321,697 bp
  • A to G, chromosome 3 at 96,167,869 bp
  • T to C, chromosome 3 at 122,817,955 bp
  • GGTTTAATGAAGAG to GG, chromosome 4 at 34,771,259 bp
  • TTTAATGAAGAGCT to TT, chromosome 4 at 34,771,261 bp
  • A to G, chromosome 4 at 116,155,736 bp
  • T to A, chromosome 4 at 135,922,962 bp
  • A to G, chromosome 4 at 154,885,587 bp
  • A to G, chromosome 5 at 4,046,064 bp
  • A to T, chromosome 5 at 69,110,485 bp
  • G to T, chromosome 5 at 84,084,728 bp
  • A to G, chromosome 5 at 108,679,734 bp
  • A to G, chromosome 5 at 114,184,106 bp
  • C to A, chromosome 6 at 22,138,682 bp
  • T to C, chromosome 6 at 82,968,102 bp
  • A to G, chromosome 6 at 112,489,496 bp
  • A to G, chromosome 7 at 25,315,521 bp
  • G to A, chromosome 7 at 45,353,616 bp
  • A to G, chromosome 7 at 83,775,980 bp
  • G to A, chromosome 7 at 127,924,816 bp
  • C to G, chromosome 8 at 47,668,826 bp
  • A to T, chromosome 8 at 122,900,633 bp
  • C to A, chromosome 11 at 117,792,629 bp
  • A to T, chromosome 12 at 55,491,220 bp
  • G to A, chromosome 12 at 80,758,790 bp
  • A to T, chromosome 12 at 113,409,633 bp
  • A to G, chromosome 13 at 50,469,855 bp
  • T to C, chromosome 14 at 26,462,280 bp
  • T to C, chromosome 15 at 91,709,390 bp
  • T to A, chromosome 15 at 101,548,385 bp
  • A to T, chromosome 16 at 10,511,805 bp
  • G to A, chromosome 17 at 23,347,963 bp
  • A to T, chromosome 17 at 35,528,848 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5821 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043401-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.