Strain Name:
C57BL/6J-MtgxR5849Btlr/Mmmh
Stock Number:
044066-MU
Citation ID:
RRID:MMRRC_044066-MU
Other Names:
R5849 (G1)
Major Collection:

Strain Information

Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Zfp384
Name: zinc finger protein 384
Synonyms: Nmp4, C130073D16Rik, Ciz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: Wolfram syndrome 1 homolog (human), wolframin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Sema3f
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: Semak, Sema IV
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20350
Homologene: 20885
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Dlgap5
Name: DLG associated protein 5
Synonyms: Hurp, C86398, Dlg7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218977
Homologene: 8840
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Srsf1
Name: serine and arginine-rich splicing factor 1
Synonyms: 1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110809
Homologene: 31411
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: mTAFI68, A230108M10Rik, 4930408G01Rik, p63
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Grin2c
Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Synonyms: NMDAR2C, NR2C, GluRepsilon3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14813
HGNC: HGNC:4587
Homologene: 647
Slfn2
Name: schlafen 2
Synonyms: Shlf2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20556
Homologene: 133205
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Flcn
Name: folliculin
Synonyms: B430214A04Rik, BHD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216805
Homologene: 14583
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235315
Homologene: 109357
Kdm4a
Name: lysine (K)-specific demethylase 4A
Synonyms: Jmjd2, D4Ertd222e, JHDM3A, Jmjd2a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230674
Homologene: 27780
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Ebf1
Name: early B cell factor 1
Synonyms: Olf-1, O/E-1, Olf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13591
HGNC: HGNC:3126
Homologene: 7297
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Nna1-l1, EG244071, Ccp4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244071
Homologene: 17552
Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75475
HGNC: HGNC:8149
Homologene: 90938
Ak9
Name: adenylate kinase 9
Synonyms: LOC215946, Akd2, Gm7127, Akd1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Itgal
Name: integrin alpha L
Synonyms: LFA-1, Cd11a, Ly-21, Ly-15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Snrpe
Name: small nuclear ribonucleoprotein E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20643
Homologene: 37729
Matn3
Name: matrilin 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17182
HGNC: HGNC:6909
Homologene: 1785
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Ppp1r36
Name: protein phosphatase 1, regulatory subunit 36
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 210762
VEGA: 12
Homologene: 52094
Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Synonyms: cholesterol 27 hydroxylase, Cyp27, 1300013A03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 104086
HGNC: HGNC:2605
Homologene: 36040
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Kcr1-1, Shab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Pacsin2
Name: protein kinase C and casein kinase substrate in neurons 2
Synonyms: Syndapin II
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23970
VEGA: 15
HGNC: HGNC:8571
Homologene: 21414
4930553M12Rik
Name: RIKEN cDNA 4930553M12 gene
Type: Gene
Species: Mouse
Chromosome: 4
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74468
Homologene: 50610
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Mup3
Name: major urinary protein 3
Synonyms: Mup-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17842
Homologene: 74304
S1pr4
Name: sphingosine-1-phosphate receptor 4
Synonyms: lpC1, S1P4, Edg6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13611
VEGA: 10
HGNC: HGNC:3170
Homologene: 2799
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Myrip
Name: myosin VIIA and Rab interacting protein
Synonyms: Slac2-c, A230081N12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245049
Homologene: 9150
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, MOR30-2, Olfr584
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Or9g19
Name: olfactory receptor family 9 subfamily G member 19
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2, Olfr1013
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258757
Homologene: 74096
Dcun1d1
Name: defective in cullin neddylation 1 domain containing 1
Synonyms: pTes3, Rp42, Tes3, SCCRO, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114893
Homologene: 10773
Tspan32
Name: tetraspanin 32
Synonyms: Tspan32, Phemx, Tssc6, D7Wsu37e, Art-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27027
Homologene: 10650
Zfp865
Name: zinc finger protein 865
Synonyms: 6430526N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319748
Homologene: 19652
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50524
Homologene: 9269
Trafd1
Name: TRAF type zinc finger domain containing 1
Synonyms: Fln29, 1110008K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231712
Homologene: 31399
Stbd1
Name: starch binding domain 1
Synonyms: D5Ertd593e, D530019K15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52331
Homologene: 2929
Or6z3
Name: olfactory receptor family 6 subfamily Z member 3
Synonyms: GA_x6K02T2QGBW-3190370-3191314, MOR103-7, Olfr1336
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258917
Homologene: 37007
Lcn9
Name: lipocalin 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77704
Homologene: 12681
Sars2
Name: seryl-aminoacyl-tRNA synthetase 2
Synonyms: 2410015F05Rik, D7Ertd353e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71984
Homologene: 6073
Comtd1
Name: catechol-O-methyltransferase domain containing 1
Synonyms: 1810030M08Rik, MT773
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69156
Homologene: 41703
Ssbp1
Name: single-stranded DNA binding protein 1
Synonyms: 2810480P10Rik, G630031O20Rik, mtDBP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381760
Homologene: 74462
Or4f14d
Name: olfactory receptor family 4 subfamily F member 14D
Synonyms: GA_x6K02T2Q125-73177039-73176101, MOR245-26, MOR245-1, Olfr1316
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258737
Homologene: 133651
Tnfsf12
Name: tumor necrosis factor (ligand) superfamily, member 12
Synonyms: Tweak, APO3L, DR3L
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21944
Homologene: 7979
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,736,684 bp
  • T to A, chromosome 1 at 75,527,355 bp
  • T to A, chromosome 1 at 133,608,914 bp
  • G to A, chromosome 2 at 25,823,256 bp
  • A to T, chromosome 2 at 59,799,904 bp
  • T to C, chromosome 2 at 76,746,242 bp
  • A to T, chromosome 2 at 85,770,424 bp
  • A to T, chromosome 2 at 112,129,878 bp
  • T to C, chromosome 2 at 113,834,847 bp
  • T to A, chromosome 2 at 167,106,026 bp
  • T to A, chromosome 3 at 35,916,184 bp
  • A to T, chromosome 3 at 36,032,877 bp
  • A to G, chromosome 3 at 105,458,795 bp
  • T to G, chromosome 4 at 62,086,935 bp
  • T to C, chromosome 4 at 86,825,986 bp
  • T to C, chromosome 4 at 88,868,359 bp
  • T to C, chromosome 4 at 117,277,612 bp
  • C to T, chromosome 4 at 118,161,840 bp
  • T to A, chromosome 5 at 29,658,409 bp
  • C to G, chromosome 5 at 36,973,264 bp
  • T to G, chromosome 5 at 92,604,995 bp
  • T to C, chromosome 5 at 121,373,471 bp
  • T to A, chromosome 6 at 24,891,556 bp
  • A to G, chromosome 6 at 37,957,729 bp
  • T to A, chromosome 6 at 40,476,903 bp
  • G to A, chromosome 6 at 125,024,099 bp
  • G to T, chromosome 7 at 5,031,087 bp
  • A to T, chromosome 7 at 6,460,994 bp
  • A to G, chromosome 7 at 28,744,258 bp
  • A to G, chromosome 7 at 68,190,033 bp
  • T to C, chromosome 7 at 76,325,098 bp
  • A to T, chromosome 7 at 80,803,158 bp
  • T to A, chromosome 7 at 103,085,521 bp
  • A to G, chromosome 7 at 127,317,320 bp
  • T to C, chromosome 7 at 143,015,587 bp
  • G to A, chromosome 9 at 45,868,088 bp
  • G to A, chromosome 9 at 107,682,616 bp
  • A to G, chromosome 9 at 120,453,693 bp
  • A to G, chromosome 10 at 41,348,049 bp
  • T to A, chromosome 10 at 79,664,990 bp
  • C to T, chromosome 10 at 81,499,323 bp
  • T to A, chromosome 11 at 44,990,504 bp
  • T to A, chromosome 11 at 59,804,760 bp
  • C to A, chromosome 11 at 60,190,521 bp
  • C to A, chromosome 11 at 69,686,967 bp
  • C to A, chromosome 11 at 83,069,576 bp
  • T to C, chromosome 11 at 88,047,858 bp
  • C to A, chromosome 11 at 109,977,813 bp
  • T to C, chromosome 11 at 115,260,991 bp
  • A to G, chromosome 11 at 115,881,933 bp
  • A to G, chromosome 12 at 8,958,829 bp
  • T to A, chromosome 12 at 24,500,525 bp
  • C to A, chromosome 12 at 76,439,157 bp
  • A to G, chromosome 13 at 46,686,976 bp
  • A to G, chromosome 13 at 63,015,498 bp
  • A to T, chromosome 13 at 92,249,878 bp
  • C to T, chromosome 14 at 21,848,120 bp
  • A to G, chromosome 14 at 47,389,435 bp
  • C to A, chromosome 14 at 52,314,247 bp
  • G to A, chromosome 15 at 6,794,006 bp
  • T to A, chromosome 15 at 76,297,347 bp
  • A to G, chromosome 15 at 83,390,518 bp
  • A to T, chromosome 16 at 32,774,839 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5849 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044066-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.