Strain Name:
C57BL/6J-MtgxR5858Btlr
Stock Number:
044070-MU
Citation ID:
RRID:MMRRC_044070-MU
Other Names:
R5858 (G1)
Major Collection:

Strain Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Ccr2
Name: chemokine (C-C motif) receptor 2
Synonyms: CC-CKR-2, CKR2B, CKR2A, CCR2B, CCR2A, CKR2, Cmkbr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12772
HGNC: HGNC:1603
Homologene: 537
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Dapp1
Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms: Bam32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26377
Homologene: 32138
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Sec23r, Msec23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20334
Homologene: 4642
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105445
Homologene: 41026
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 2810417M16Rik, D130033C15Rik, 9830127L17Rik, 2700078E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78832
VEGA: 19
Homologene: 17821
Arl5a
Name: ADP-ribosylation factor-like 5A
Synonyms: 2410015N24Rik, 2810410P22Rik, Arl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75423
HGNC: HGNC:696
Homologene: 100572
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229725
Homologene: 9032
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Vars
Name: valyl-tRNA synthetase
Synonyms: G7a, D17H6S56E, Bat-6, Bat6, Vars2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22321
Homologene: 4587
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269328
Homologene: 51680
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Cops7a
Name: COP9 signalosome subunit 7A
Synonyms: COP9 complex S7a, D6Ertd35e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26894
Homologene: 22685
Zfp287
Name: zinc finger protein 287
Synonyms: SKAT-2, B230333C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170740
Homologene: 23244
Alg14
Name: asparagine-linked glycosylation 14
Synonyms: 5430428G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66789
Homologene: 49751
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58227
Homologene: 137353
Ephb2
Name: Eph receptor B2
Synonyms: eteck, Erk, Tyro5, Prkm5, Nuk, Drt, Hek5, Sek3, Qek5, Cek5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Dnase1
Name: deoxyribonuclease I
Synonyms: DNaseI, Dnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13419
HGNC: HGNC:2956
Homologene: 3826
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Ak9
Name: adenylate kinase 9
Synonyms: LOC215946, Akd2, Gm7127, Akd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 633979
Homologene: 67934
Rfx6
Name: regulatory factor X, 6
Synonyms: 4930572O07Rik, Rfxdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320995
Homologene: 18318
Or5b94
Name: olfactory receptor family 5 subfamily B member 94
Synonyms: GA_x6K02T2RE5P-3000589-3001527, MOR202-9, Olfr1442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258692
HGNC: HGNC:8324
Homologene: 138315
Krt24
Name: keratin 24
Synonyms: 2310075C18Rik, 2310058N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75706
Homologene: 10379
P4ha1
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Synonyms: P4ha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18451
HGNC: HGNC:8546
Homologene: 30998
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: JIP-1, MAPK8IP1, IB1, Prkm8ip, mjip-2a, Skip, Jip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Tha1
Name: threonine aldolase 1
Synonyms: GLY1, 1300017K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71776
Homologene: 57081
Rxrg
Name: retinoid X receptor gamma
Synonyms: Nr2b3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20183
Homologene: 21373
Or2ag1
Name: olfactory receptor family 2 subfamily AG member 1
Synonyms: GA_x6K02T2PBJ9-9256348-9255398, MOR283-2, Olfr705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259034
Homologene: 128075
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209462
Homologene: 10807
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77057
Homologene: 122152
Ubqln5
Name: ubiquilin 5
Synonyms: 4931431F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70980
Homologene: 78030
Or2m13
Name: olfactory receptor family 2 subfamily M member 13
Synonyms: GA_x54KRFPKG5P-15855164-15854223, MOR279-1, Olfr165
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258458
Homologene: 128262
Il6
Name: interleukin 6
Synonyms: Il-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16193
HGNC: HGNC:6018
Homologene: 502
Or12e10
Name: olfactory receptor family 12 subfamily E member 10
Synonyms: GA_x6K02T2Q125-49311440-49312384, MOR264-19, Olfr1145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258317
Homologene: 27123
Col8a2
Name: collagen, type VIII, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329941
HGNC: HGNC:2216
Homologene: 55879
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Casper, A430105C05Rik, Flip, c-Flip, 2310024N18Rik, Cash
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
2310009B15Rik
Name: RIKEN cDNA 2310009B15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69549
Homologene: 19923
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12939
Homologene: 117962
Il31
Name: interleukin 31
Synonyms: 1700013B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76399
Homologene: 130770
Rpp25l
Name: ribonuclease P/MRP 25 subunit-like
Synonyms: 2810432D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69961
Homologene: 41714
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,753,851 bp
  • T to A, chromosome 1 at 138,853,605 bp
  • A to T, chromosome 1 at 167,627,356 bp
  • T to C, chromosome 2 at 52,412,106 bp
  • A to T, chromosome 2 at 87,810,641 bp
  • A to G, chromosome 2 at 92,384,972 bp
  • A to G, chromosome 2 at 110,731,798 bp
  • G to T, chromosome 2 at 132,302,113 bp
  • A to G, chromosome 3 at 55,953,034 bp
  • A to G, chromosome 3 at 108,661,428 bp
  • G to A, chromosome 3 at 121,320,088 bp
  • T to C, chromosome 3 at 137,961,531 bp
  • A to T, chromosome 4 at 41,712,678 bp
  • T to C, chromosome 4 at 63,166,410 bp
  • C to T, chromosome 4 at 126,311,300 bp
  • T to C, chromosome 4 at 136,672,445 bp
  • T to C, chromosome 4 at 141,473,871 bp
  • A to T, chromosome 5 at 30,013,474 bp
  • C to T, chromosome 5 at 43,715,775 bp
  • A to T, chromosome 5 at 45,639,119 bp
  • T to A, chromosome 5 at 123,480,574 bp
  • A to T, chromosome 6 at 124,960,171 bp
  • T to C, chromosome 7 at 104,128,811 bp
  • T to A, chromosome 7 at 106,873,768 bp
  • T to A, chromosome 9 at 111,392,536 bp
  • A to G, chromosome 9 at 124,106,427 bp
  • G to A, chromosome 10 at 41,423,027 bp
  • A to G, chromosome 10 at 45,711,525 bp
  • A to G, chromosome 10 at 51,725,868 bp
  • A to T, chromosome 10 at 59,339,378 bp
  • T to A, chromosome 11 at 62,714,007 bp
  • A to T, chromosome 11 at 99,284,765 bp
  • A to G, chromosome 11 at 117,873,384 bp
  • A to G, chromosome 12 at 58,973,035 bp
  • T to C, chromosome 13 at 11,560,574 bp
  • A to G, chromosome 14 at 121,628,792 bp
  • T to A, chromosome 15 at 12,442,589 bp
  • A to T, chromosome 15 at 73,321,095 bp
  • T to C, chromosome 16 at 4,039,649 bp
  • A to G, chromosome 16 at 19,407,225 bp
  • A to G, chromosome 17 at 24,445,328 bp
  • C to T, chromosome 17 at 35,005,475 bp
  • A to G, chromosome 17 at 88,635,631 bp
  • A to G, chromosome 18 at 36,976,226 bp
  • A to T, chromosome 18 at 44,510,141 bp
  • T to A, chromosome 18 at 77,948,299 bp
  • C to T, chromosome 19 at 10,254,968 bp
  • A to G, chromosome 19 at 12,674,379 bp
  • T to C, chromosome 19 at 60,529,044 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5858 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044070-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.