Strain Name:
C57BL/6J-MtgxR5886Btlr/Mmmh
Stock Number:
044088-MU
Citation ID:
RRID:MMRRC_044088-MU
Other Names:
R5886 (G1)
Major Collection:

Strain Information

Tk1
Name: thymidine kinase 1
Synonyms: Tk-1, D530002A18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21877
Homologene: 37749
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109241
Homologene: 81861
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, Red
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Akap1
Name: A kinase anchor protein 1
Synonyms: S-AKAP84, AKAP84, AKAP121, DAKAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11640
HGNC: HGNC:367
Homologene: 31165
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269338
Homologene: 41025
Mtg1
Name: mitochondrial ribosome-associated GTPase 1
Synonyms: LOC212508, Gtpbp7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212508
Homologene: 44527
Lca5
Name: Leber congenital amaurosis 5 (human)
Synonyms: 5730406O13Rik, ORF64, 4930431B11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75782
Homologene: 32718
Cd200r1
Name: CD200 receptor 1
Synonyms: OX2R, CD200R, Mox2r
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57781
Homologene: 10957
Akap5
Name: A kinase anchor protein 5
Synonyms: LOC238276, AKAP150, 3526401B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238276
HGNC: HGNC:375
Homologene: 15854
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22696
Homologene: 40682
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mouse
Chromosome: 4
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Hcrt
Name: hypocretin
Synonyms: orexin A, orexin B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15171
HGNC: HGNC:4847
Homologene: 1166
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69439
Homologene: 72545
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: ANG1, 3110041O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Nubpl
Name: nucleotide binding protein-like
Synonyms: 2410170E07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76826
Homologene: 11854
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381260
Homologene: 124277
Or8g23
Name: olfactory receptor family 8 subfamily G member 23
Synonyms: GA_x6K02T2PVTD-32756567-32755632, MOR171-24, Olfr937
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258431
VEGA: 9
HGNC: HGNC:8484
Homologene: 27167
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216859
Homologene: 22835
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Hars2
Name: histidyl-tRNA synthetase 2
Synonyms: HARSR, HO3, 4631412B19Rik, Harsl
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70791
HGNC: HGNC:4817
Homologene: 40819
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238384
Homologene: 17798
Ccdc154
Name: coiled-coil domain containing 154
Synonyms: LOC207209, ntl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 207209
Homologene: 19361
Or9g20
Name: olfactory receptor family 9 subfamily G member 20
Synonyms: GA_x6K02T2Q125-47278889-47277960, MOR213-9, Olfr1016
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257915
Homologene: 83133
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382407
VEGA: 10
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Mfsd4a
Name: major facilitator superfamily domain containing 4A
Synonyms: A930031D07Rik, Mfsd4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213006
Homologene: 45419
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235636
Homologene: 135957
Nanos1
Name: nanos C2HC-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 332397
VEGA: 19
Homologene: 131234
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Naprt
Name: nicotinate phosphoribosyltransferase
Synonyms: 9130210N20Rik, Naprt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223646
VEGA: 15
Homologene: 82285
Cyp4f17
Name: cytochrome P450, family 4, subfamily f, polypeptide 17
Synonyms: EG208285
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 208285
VEGA: 17
Homologene: 129713
Coq4
Name: coenzyme Q4
Synonyms: D2Ertd97e, EST-MNCb4625
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227683
Homologene: 68641
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213696
Homologene: 16043
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Prlhr
Name: prolactin releasing hormone receptor
Synonyms: LOC226278, PrRPR, GR3, Gpr10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226278
VEGA: 19
HGNC: HGNC:4464
Homologene: 3134
Mpi
Name: mannose phosphate isomerase
Synonyms: Mpi-1, 1110002E17Rik, Mpi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110119
HGNC: HGNC:7216
Homologene: 1825
Trim35
Name: tripartite motif-containing 35
Synonyms: Mair, 0710005M05Rik, A430106H13Rik, Hls5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66854
Homologene: 134331
Or10ad1b
Name: olfactory receptor family 10 subfamily AD member 1B
Synonyms: GA_x6K02T2NBG7-5528233-5529186, MOR286-2, EG629524, Olfr286
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 629524
Homologene: 134078
Zdhhc3
Name: zinc finger, DHHC domain containing 3
Synonyms: 1810006O10Rik, Zfp373, GODZ, 1110020O22Rik, 2210017C02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69035
Homologene: 9582
Or10d4
Name: olfactory receptor family 10 subfamily D member 4
Synonyms: GA_x6K02T2PVTD-33365879-33366814, MOR224-7P, MOR224-13, Olfr963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258087
VEGA: 9
Homologene: 105216
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: CYSLT2R, Cyslt2, CysLT2, 2300001H05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
C1qtnf7
Name: C1q and tumor necrosis factor related protein 7
Synonyms: 5530401N20Rik, 8430425G24Rik, CTRP7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109323
Homologene: 12900
C1qbp
Name: complement component 1, q subcomponent binding protein
Synonyms: P32, HABP1, D11Wsu182e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12261
HGNC: HGNC:1243
Homologene: 31023
Efcab15
Name: EF-hand calcium binding domain 15
Synonyms: 1700023F06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69441
Homologene: 132455
D930007J09Rik
Name: RIKEN cDNA D930007J09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Tuba5-ps
Name: tubulin alpha 5, pseudogene
Synonyms: Gm29376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102634941
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 59,558,250 bp
  • C to T, chromosome 1 at 84,730,458 bp
  • T to C, chromosome 1 at 116,571,672 bp
  • C to T, chromosome 1 at 132,067,727 bp
  • A to G, chromosome 1 at 134,520,199 bp
  • A to T, chromosome 2 at 13,320,023 bp
  • A to T, chromosome 2 at 29,790,614 bp
  • A to G, chromosome 2 at 49,272,452 bp
  • A to G, chromosome 2 at 85,799,803 bp
  • A to G, chromosome 2 at 120,321,572 bp
  • A to G, chromosome 2 at 121,205,021 bp
  • A to T, chromosome 2 at 122,303,810 bp
  • C to A, chromosome 3 at 89,220,163 bp
  • T to A, chromosome 3 at 104,462,698 bp
  • T to A, chromosome 4 at 57,856,295 bp
  • A to G, chromosome 4 at 62,191,234 bp
  • T to C, chromosome 5 at 17,681,986 bp
  • G to A, chromosome 5 at 43,615,656 bp
  • A to G, chromosome 7 at 28,887,605 bp
  • A to G, chromosome 7 at 130,729,120 bp
  • G to T, chromosome 7 at 140,149,865 bp
  • T to C, chromosome 8 at 43,520,273 bp
  • G to A, chromosome 8 at 45,027,681 bp
  • A to T, chromosome 8 at 45,033,395 bp
  • T to A, chromosome 8 at 79,672,807 bp
  • T to C, chromosome 8 at 84,523,022 bp
  • T to A, chromosome 9 at 39,060,382 bp
  • G to T, chromosome 9 at 39,669,956 bp
  • A to G, chromosome 9 at 57,548,462 bp
  • G to A, chromosome 9 at 83,399,681 bp
  • A to G, chromosome 9 at 110,987,136 bp
  • A to T, chromosome 9 at 123,091,081 bp
  • G to A, chromosome 10 at 99,445,147 bp
  • A to G, chromosome 11 at 69,884,336 bp
  • A to G, chromosome 11 at 70,982,182 bp
  • C to T, chromosome 11 at 83,003,334 bp
  • A to G, chromosome 11 at 88,834,660 bp
  • C to T, chromosome 11 at 99,540,081 bp
  • G to A, chromosome 11 at 100,761,933 bp
  • A to G, chromosome 11 at 103,208,121 bp
  • CC to GA, chromosome 11 at 117,817,122 bp
  • T to A, chromosome 12 at 52,181,309 bp
  • T to A, chromosome 12 at 76,327,845 bp
  • T to C, chromosome 12 at 102,260,415 bp
  • C to A, chromosome 13 at 32,802,836 bp
  • A to G, chromosome 13 at 42,156,612 bp
  • A to T, chromosome 13 at 96,660,183 bp
  • C to T, chromosome 14 at 20,561,842 bp
  • C to G, chromosome 14 at 66,304,053 bp
  • T to C, chromosome 14 at 66,304,054 bp
  • T to C, chromosome 14 at 73,029,491 bp
  • A to T, chromosome 15 at 58,098,514 bp
  • G to T, chromosome 15 at 74,606,447 bp
  • A to C, chromosome 15 at 75,891,475 bp
  • A to T, chromosome 15 at 89,103,247 bp
  • T to C, chromosome 15 at 98,226,791 bp
  • T to A, chromosome 16 at 37,979,013 bp
  • T to C, chromosome 16 at 44,790,203 bp
  • C to T, chromosome 17 at 25,171,818 bp
  • T to C, chromosome 17 at 28,876,863 bp
  • C to T, chromosome 17 at 30,794,717 bp
  • A to T, chromosome 17 at 32,524,039 bp
  • T to C, chromosome 17 at 53,451,554 bp
  • T to C, chromosome 18 at 20,874,680 bp
  • T to A, chromosome 18 at 36,790,097 bp
  • T to C, chromosome 18 at 76,859,429 bp
  • A to G, chromosome 19 at 6,066,542 bp
  • T to C, chromosome 19 at 16,664,562 bp
  • C to A, chromosome 19 at 27,243,771 bp
  • T to C, chromosome 19 at 29,719,277 bp
  • C to T, chromosome 19 at 60,467,576 bp
  • T to A, chromosome 19 at 60,756,830 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5886 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044088-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.