Strain Name:
C57BL/6J-MtgxR5889Btlr
Stock Number:
044090-MU
Citation ID:
RRID:MMRRC_044090-MU
Other Names:
R5889 (G1)
Major Collection:

Strain Information

Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170707
Homologene: 12988
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Exoc6
Name: exocyst complex component 6
Synonyms: msec15, 4833405E05Rik, Sec15, Sec15l1, hbd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: 17[b]-HSD, MFE-2, perMFE-2, multifunctional protein 2, D-bifunctional protein, Mfp-2, MFP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Hspa5
Name: heat shock protein 5
Synonyms: Bip, Grp78, Hsce70, D2Wsu141e, D2Wsu17e, Sez7, 78kDa, mBiP, XAP-1 antigen, baffled
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14828
HGNC: HGNC:5238
Homologene: 3908
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: SPAG13, CS-1, CS1, KRAP, Ssfa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70599
Homologene: 4912
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Nop56
Name: NOP56 ribonucleoprotein
Synonyms: NOP56, 56kDa with KKE/D repeat, 2310044F10Rik, Nol5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67134
Homologene: 4660
Wbp1l
Name: WW domain binding protein 1 like
Synonyms: D19Wsu162e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226178
Homologene: 9839
Rtca
Name: RNA 3'-terminal phosphate cyclase
Synonyms: 2310009A18Rik, Rtcd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66368
Homologene: 2766
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20926
Homologene: 40661
Ube2d1
Name: ubiquitin-conjugating enzyme E2D 1
Synonyms: UBCH5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216080
Homologene: 20714
Stard3
Name: START domain containing 3
Synonyms: es64, Mln64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 59045
Homologene: 38227
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216766
Homologene: 9155
Prom2
Name: prominin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192212
Homologene: 44536
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Cilp
Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms: C130036G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214425
HGNC: HGNC:1980
Homologene: 2679
Nos3
Name: nitric oxide synthase 3, endothelial cell
Synonyms: eNOS, ecNOS, Nos-3, 2310065A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18127
HGNC: HGNC:7876
Homologene: 504
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: 9430010M12Rik, D8Ertd354e, Tmem76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52120
Homologene: 15586
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320714
Homologene: 11076
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Scube3
Name: signal peptide, CUB domain, EGF-like 3
Synonyms: D030038I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268935
Homologene: 65059
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: MyHC-emb, Myhs-e, Myhse
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Fndc8
Name: fibronectin type III domain containing 8
Synonyms: 4930466G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78919
Homologene: 9716
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
4930568D16Rik
Name: RIKEN cDNA 4930568D16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75859
Homologene: 86865
Gtf2h4
Name: general transcription factor II H, polypeptide 4
Synonyms: p52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14885
HGNC: HGNC:4658
Homologene: 7090
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: BPAg2, BP180, Bpag, Bpag2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22151
VEGA: 13
Homologene: 134314
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68666
Homologene: 41283
Hsd17b7
Name: hydroxysteroid (17-beta) dehydrogenase 7
Synonyms: ERG27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15490
HGNC: HGNC:5215
Homologene: 40728
Sprr1a
Name: small proline-rich protein 1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20753
Homologene: 105698
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: LOC242610, 1110046I03Rik, D4Mgi23, 2810482G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 414872
Homologene: 14600
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Mettl24
Name: methyltransferase like 24
Synonyms: 9030224M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327747
Homologene: 65335
Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Synonyms: CREB-H, D10Bur1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208677
Homologene: 13080
Prss48
Name: protease, serine 48
Synonyms: Esspl, Gm1019
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 368202
Homologene: 133731
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 4432406M01Rik, 1110034E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Gm10118
Name: predicted gene 10118
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ttll8
Name: tubulin tyrosine ligase-like family, member 8
Synonyms: 1700019P01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239591
Homologene: 52766
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209760
Homologene: 36424
Ebna1bp2
Name: EBNA1 binding protein 2
Synonyms: p40, 1810014B19Rik, Nobp, Ebp2, B830003A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69072
Homologene: 4969
Or13c7b
Name: olfactory receptor family 13 subfamily C member 7B
Synonyms: OR37B, mOR37b, Olfr37b, MOR262-6, GA_x6K02T2N78B-16125144-16126100, Olfr156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29846
Homologene: 133652
Gabra4
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
Synonyms: Gabra-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14397
HGNC: HGNC:4078
Homologene: 631
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 158,600,380 bp
  • A to T, chromosome 1 at 169,955,918 bp
  • T to C, chromosome 2 at 34,774,617 bp
  • T to C, chromosome 2 at 35,354,449 bp
  • T to C, chromosome 2 at 76,730,649 bp
  • T to A, chromosome 2 at 79,657,728 bp
  • C to T, chromosome 2 at 127,529,411 bp
  • G to T, chromosome 2 at 130,275,982 bp
  • T to C, chromosome 2 at 180,193,674 bp
  • A to C, chromosome 2 at 181,028,658 bp
  • A to G, chromosome 3 at 85,998,185 bp
  • G to T, chromosome 3 at 92,484,644 bp
  • T to C, chromosome 3 at 116,499,583 bp
  • T to A, chromosome 3 at 129,312,578 bp
  • G to T, chromosome 3 at 135,524,598 bp
  • T to C, chromosome 4 at 43,820,492 bp
  • C to T, chromosome 4 at 108,237,380 bp
  • T to A, chromosome 4 at 118,621,423 bp
  • T to C, chromosome 4 at 137,616,412 bp
  • C to A, chromosome 5 at 24,368,777 bp
  • A to T, chromosome 5 at 71,571,891 bp
  • A to T, chromosome 5 at 114,065,631 bp
  • T to C, chromosome 6 at 3,376,460 bp
  • A to G, chromosome 7 at 87,603,073 bp
  • A to C, chromosome 7 at 118,566,326 bp
  • T to C, chromosome 8 at 25,963,367 bp
  • G to A, chromosome 8 at 47,519,578 bp
  • T to C, chromosome 8 at 80,614,288 bp
  • C to T, chromosome 8 at 105,888,022 bp
  • C to A, chromosome 9 at 65,280,343 bp
  • T to A, chromosome 10 at 40,746,490 bp
  • A to G, chromosome 10 at 63,927,111 bp
  • A to T, chromosome 10 at 71,259,869 bp
  • T to C, chromosome 10 at 81,092,533 bp
  • T to C, chromosome 10 at 100,499,074 bp
  • A to G, chromosome 11 at 58,122,355 bp
  • A to G, chromosome 11 at 67,086,375 bp
  • A to G, chromosome 11 at 78,212,748 bp
  • A to T, chromosome 11 at 82,898,729 bp
  • G to C, chromosome 11 at 98,375,535 bp
  • G to T, chromosome 11 at 105,921,807 bp
  • T to A, chromosome 12 at 76,072,252 bp
  • G to T, chromosome 12 at 101,765,226 bp
  • A to T, chromosome 13 at 34,075,468 bp
  • A to G, chromosome 13 at 95,632,042 bp
  • A to T, chromosome 14 at 32,166,659 bp
  • G to C, chromosome 15 at 88,933,939 bp
  • A to G, chromosome 17 at 27,115,065 bp
  • A to G, chromosome 17 at 28,160,913 bp
  • C to A, chromosome 17 at 32,675,757 bp
  • G to A, chromosome 17 at 35,670,900 bp
  • T to G, chromosome 18 at 20,283,601 bp
  • T to A, chromosome 18 at 37,676,609 bp
  • T to A, chromosome 18 at 50,177,209 bp
  • T to A, chromosome 19 at 27,239,664 bp
  • A to G, chromosome 19 at 37,582,245 bp
  • C to T, chromosome 19 at 46,654,180 bp
  • A to G, chromosome 19 at 47,649,072 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5889 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044090-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.