Strain Name:
C57BL/6J-MtgxR5897Btlr/Mmmh
Stock Number:
044096-MU
Citation ID:
RRID:MMRRC_044096-MU
Other Names:
R5897 (G1)
Major Collection:

Strain Information

Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
Synonyms: Step
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19259
HGNC: HGNC:9657
Homologene: 8423
Txn2
Name: thioredoxin 2
Synonyms: Trx2, 2510006J11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56551
Homologene: 40849
Rab1a
Name: RAB1A, member RAS oncogene family
Synonyms: Gtbp, ras-related YPT1 protein, Rab1, Ypt1, Rab-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19324
HGNC: HGNC:9758
Homologene: 36154
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4833420O05Rik, 4631402N15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Prr12
Name: proline rich 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233210
Homologene: 18957
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, 5730481H23Rik, mei2-5, AKAP450, repro12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, HBLP1, AD3, GRAM domain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, 1500009K01Rik, WDR30
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Tmub1
Name: transmembrane and ubiquitin-like domain containing 1
Synonyms: Hops, 2010004O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64295
Homologene: 11187
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: Sam68, p62
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20218
Homologene: 4781
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77951
Homologene: 18584
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Vax1
Name: ventral anterior homeobox 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22326
Homologene: 7593
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142682
Homologene: 9037
Ush2a
Name: usherin
Synonyms: Ushrn, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, LOC381317, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
BC024139
Name: cDNA sequence BC024139
Synonyms: 6230424I18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271278
Homologene: 129974
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, Ccp3, Ccp3, 6530406M24Rik, 4930431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Pcdhb13
Name: protocadherin beta 13
Synonyms: PcdhbM, Pcdbh6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic phospholipase A2, cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Tinag
Name: tubulointerstitial nephritis antigen
Synonyms: TIN-ag
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26944
Homologene: 8082
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: OTTMUSG00000007939, Cyp2j12-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Pbx3
Name: pre B cell leukemia homeobox 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18516
HGNC: HGNC:8634
Homologene: 21243
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49i2, Ly49J
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Or2t1
Name: olfactory receptor family 2 subfamily T member 1
Synonyms: MTPCR53, MOR274-1, GA_x6K02T2PLTE-6714644-6715597, Olfr31
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18330
HGNC: HGNC:8277
Homologene: 74028
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Skint9
Name: selection and upkeep of intraepithelial T cells 9
Synonyms: A030013N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329918
Homologene: 136292
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, ADAM3, Taz83, tMDC, Cyrn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433247
Homologene: 74936
Ccdc121
Name: coiled-coil domain containing 121
Synonyms: 4930548H24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67656
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: Csh2, Pl-2, Pl2, mplII, mPL-II, PL, prolactin-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18776
Homologene: 7476
Gje1
Name: gap junction protein, epsilon 1
Synonyms: AEY12, connexin 23, Gjf1, D230044M03Rik, Gsfaey12, Cx23
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76743
Homologene: 87405
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Or2i1
Name: olfactory receptor family 2 subfamily I member 1
Synonyms: Olfr94, GA_x6K02T2PSCP-1637650-1636712, MOR256-32P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258219
HGNC: HGNC:8258
Homologene: 79123
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,392,109 bp
  • A to C, chromosome 1 at 60,353,061 bp
  • G to T, chromosome 1 at 87,785,997 bp
  • T to A, chromosome 1 at 149,865,148 bp
  • G to A, chromosome 1 at 188,821,738 bp
  • A to T, chromosome 2 at 34,371,908 bp
  • C to A, chromosome 3 at 64,415,266 bp
  • G to A, chromosome 3 at 83,285,410 bp
  • T to A, chromosome 3 at 158,164,353 bp
  • T to C, chromosome 4 at 96,102,042 bp
  • A to G, chromosome 4 at 112,413,916 bp
  • A to T, chromosome 4 at 129,720,655 bp
  • T to C, chromosome 5 at 4,077,904 bp
  • G to A, chromosome 5 at 24,446,927 bp
  • T to C, chromosome 5 at 31,485,964 bp
  • A to G, chromosome 6 at 34,803,573 bp
  • T to A, chromosome 6 at 130,281,829 bp
  • C to T, chromosome 7 at 45,043,384 bp
  • C to T, chromosome 7 at 47,079,514 bp
  • A to T, chromosome 7 at 131,196,551 bp
  • G to T, chromosome 8 at 3,439,682 bp
  • T to C, chromosome 8 at 24,697,228 bp
  • T to C, chromosome 8 at 81,005,453 bp
  • T to C, chromosome 8 at 121,605,160 bp
  • C to A, chromosome 9 at 77,045,444 bp
  • G to A, chromosome 9 at 83,790,104 bp
  • A to T, chromosome 10 at 14,716,723 bp
  • A to T, chromosome 10 at 105,413,598 bp
  • G to A, chromosome 10 at 107,777,117 bp
  • T to C, chromosome 11 at 8,879,176 bp
  • C to T, chromosome 11 at 20,218,867 bp
  • T to A, chromosome 12 at 72,159,804 bp
  • A to G, chromosome 13 at 27,245,875 bp
  • A to G, chromosome 13 at 64,088,985 bp
  • G to T, chromosome 14 at 14,328,120 bp
  • A to G, chromosome 15 at 76,126,139 bp
  • G to A, chromosome 15 at 77,924,526 bp
  • A to T, chromosome 15 at 82,851,783 bp
  • A to G, chromosome 16 at 56,604,669 bp
  • C to T, chromosome 17 at 20,471,318 bp
  • G to T, chromosome 17 at 27,435,163 bp
  • A to T, chromosome 17 at 37,197,260 bp
  • T to A, chromosome 17 at 43,624,877 bp
  • A to G, chromosome 18 at 34,454,081 bp
  • T to A, chromosome 18 at 37,443,211 bp
  • T to A, chromosome 18 at 67,638,328 bp
  • T to C, chromosome 19 at 39,712,531 bp
  • T to A, chromosome 19 at 59,169,801 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5897 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044096-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.