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Strain Name:
C57BL/6J-MtgxR5897Btlr/Mmmh
Stock Number:
044096-MU
Citation ID:
RRID:MMRRC_044096-MU
Other Names:
R5897 (G1)
Major Collection:

Strain Information

Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
Synonyms: Step
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19259
HGNC: HGNC:9657
Homologene: 8423
Txn2
Name: thioredoxin 2
Synonyms: 2510006J11Rik, Trx2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56551
Homologene: 40849
Rab1a
Name: RAB1A, member RAS oncogene family
Synonyms: ras-related YPT1 protein, Ypt1, Rab-1, Gtbp, Rab1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19324
HGNC: HGNC:9758
Homologene: 36154
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,392,109 bp
  • A to C, chromosome 1 at 60,353,061 bp
  • G to T, chromosome 1 at 87,785,997 bp
  • T to A, chromosome 1 at 149,865,148 bp
  • G to A, chromosome 1 at 188,821,738 bp
  • A to T, chromosome 2 at 34,371,908 bp
  • C to A, chromosome 3 at 64,415,266 bp
  • G to A, chromosome 3 at 83,285,410 bp
  • T to A, chromosome 3 at 158,164,353 bp
  • T to C, chromosome 4 at 96,102,042 bp
  • A to G, chromosome 4 at 112,413,916 bp
  • A to T, chromosome 4 at 129,720,655 bp
  • T to C, chromosome 5 at 4,077,904 bp
  • G to A, chromosome 5 at 24,446,927 bp
  • T to C, chromosome 5 at 31,485,964 bp
  • A to G, chromosome 6 at 34,803,573 bp
  • T to A, chromosome 6 at 130,281,829 bp
  • C to T, chromosome 7 at 45,043,384 bp
  • C to T, chromosome 7 at 47,079,514 bp
  • A to T, chromosome 7 at 131,196,551 bp
  • G to T, chromosome 8 at 3,439,682 bp
  • T to C, chromosome 8 at 24,697,228 bp
  • T to C, chromosome 8 at 81,005,453 bp
  • T to C, chromosome 8 at 121,605,160 bp
  • C to A, chromosome 9 at 77,045,444 bp
  • G to A, chromosome 9 at 83,790,104 bp
  • A to T, chromosome 10 at 14,716,723 bp
  • A to T, chromosome 10 at 105,413,598 bp
  • G to A, chromosome 10 at 107,777,117 bp
  • T to C, chromosome 11 at 8,879,176 bp
  • C to T, chromosome 11 at 20,218,867 bp
  • T to A, chromosome 12 at 72,159,804 bp
  • A to G, chromosome 13 at 27,245,875 bp
  • A to G, chromosome 13 at 64,088,985 bp
  • G to T, chromosome 14 at 14,328,120 bp
  • A to G, chromosome 15 at 76,126,139 bp
  • G to A, chromosome 15 at 77,924,526 bp
  • A to T, chromosome 15 at 82,851,783 bp
  • A to G, chromosome 16 at 56,604,669 bp
  • C to T, chromosome 17 at 20,471,318 bp
  • G to T, chromosome 17 at 27,435,163 bp
  • A to T, chromosome 17 at 37,197,260 bp
  • T to A, chromosome 17 at 43,624,877 bp
  • A to G, chromosome 18 at 34,454,081 bp
  • T to A, chromosome 18 at 37,443,211 bp
  • T to A, chromosome 18 at 67,638,328 bp
  • T to C, chromosome 19 at 39,712,531 bp
  • T to A, chromosome 19 at 59,169,801 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5897 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044096-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.