Strain Name:
C57BL/6J-MtgxR5908Btlr
Stock Number:
044105-MU
Citation ID:
RRID:MMRRC_044105-MU
Other Names:
R5908 (G1)
Major Collection:

Gene Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: nmf261, neuroaxonal dystrophy, Spnb4, 1700022P15Rik, SpbIV, ROSA62, dyn, 5830426A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80297
Homologene: 11879
Notch2
Name: notch 2
Synonyms: N2, Motch B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27223
Homologene: 4137
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224650
Homologene: 9068
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270685
Homologene: 56706
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328329
Homologene: 42094
Foxo3
Name: forkhead box O3
Synonyms: 2010203A17Rik, Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56484
HGNC: HGNC:3821
Homologene: 31039
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, A330070M20Rik, Cain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239667
Homologene: 72227
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100683
Homologene: 39246
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: 1200006P13Rik, 6430709P13Rik, NHE8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77031
Homologene: 75041
Hip1
Name: huntingtin interacting protein 1
Synonyms: A930014B11Rik, E130315I21Rik, 2610109B09Rik, HIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 4732460C16Rik, TAF2B, CIF150, TAFII150, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
C77080
Name: expressed sequence C77080
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97130
Homologene: 45837
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, Klkbp, alpha-1 antiproteinase, 1A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Il1f5
Name: interleukin 1 family, member 5 (delta)
Synonyms: FIL1delta, IL1HY1, IL1F5, IL-1H3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54450
Homologene: 10453
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 2410026C18Rik, eIF2alpha, Eif2a, 0910001O23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70422
Homologene: 10801
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: Lcn7, androgen-regulated gene 1, Arg1, 1110021J17Rik, AZ-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94242
Homologene: 41472
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: tailless, Tlx, Mtll, Nr2e1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231125
Homologene: 15119
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Olfr702
Name: olfactory receptor 702
Synonyms: MOR260-4, GA_x6K02T2PBJ9-9202245-9201289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258590
Homologene: 121512
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71310
Homologene: 57079
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Pnmal2
Name: PNMA-like 2
Synonyms: EG434128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434128
Homologene: 35491
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
Synonyms: p55, p55pik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18710
HGNC: HGNC:8981
Homologene: 2690
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98402
Homologene: 8726
Clip3
Name: CAP-GLY domain containing linker protein 3
Synonyms: 1500005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76686
Homologene: 9176
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: 4933417C16Rik, March10, OTTMUSG00000002847, Rnf190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 632687
Homologene: 34988
Tor2a
Name: torsin family 2, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30933
Homologene: 25260
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Gm4841
Name: predicted gene 4841
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225594
VEGA: 18
Polb
Name: polymerase (DNA directed), beta
Synonyms: Pol beta, A430088C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18970
HGNC: HGNC:9174
Homologene: 2013
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
4933416C03Rik
Name: RIKEN cDNA 4933416C03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: PNPase, polynucleotide phosphorylase, 1200003F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71701
Homologene: 12404
Bcl2a1c
Name: B cell leukemia/lymphoma 2 related protein A1c
Synonyms: A1-c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12046
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73430
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Pom121l2
Name: POM121 membrane glycoprotein-like 2 (rat)
Synonyms: LOC195236
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 195236
Homologene: 123536
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237353
Homologene: 77551
Use1
Name: unconventional SNARE in the ER 1 homolog (S. cerevisiae)
Synonyms: Q-SNARE, 2010315L10Rik, 5730403H22Rik, mED2, D12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67023
Homologene: 10214
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404238
Homologene: 138632
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 2410004N05Rik, 1300018I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72325
Homologene: 21021
B9d2
Name: B9 protein domain 2
Synonyms: stumpy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232987
Homologene: 12733
Commd5
Name: COMM domain containing 5
Synonyms: Hcarg, 2310065H03Rik, D15Ertd81e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66398
Homologene: 8548
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: Rab8ip, BL44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Prl8a1
Name: prolactin family 8, subfamily a, member 1
Synonyms: Plpcd, Prlpc4, 1600017L04Rik, 3830403L08Rik, PLP-Cd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73244
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 2610312F20Rik, 6332415K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70461
Homologene: 11248
Btbd8
Name: BTB (POZ) domain containing 8
Synonyms: Gm16115, EG627196
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100503185
VEGA: 5
Homologene: 82388
Zfp36l1
Name: zinc finger protein 36, C3H type-like 1
Synonyms: TIS11b, Brf1, cMG1, D530020L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12192
VEGA: 12
HGNC: HGNC:1107
Homologene: 31276
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100416706
Homologene: 133713
B230208B08Rik
Name: RIKEN cDNA B230208B08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 102634132
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 89,145,883 bp
  • G to A, chromosome 1 at 135,918,883 bp
  • C to T, chromosome 2 at 20,743,907 bp
  • G to T, chromosome 2 at 24,277,490 bp
  • A to G, chromosome 2 at 31,991,341 bp
  • T to C, chromosome 2 at 32,761,685 bp
  • A to G, chromosome 2 at 121,236,823 bp
  • C to T, chromosome 2 at 167,451,170 bp
  • T to C, chromosome 3 at 98,123,923 bp
  • A to G, chromosome 4 at 78,214,060 bp
  • A to T, chromosome 4 at 116,272,758 bp
  • A to G, chromosome 4 at 129,222,148 bp
  • G to T, chromosome 4 at 130,172,970 bp
  • A to T, chromosome 5 at 34,216,870 bp
  • T to G, chromosome 5 at 107,507,594 bp
  • A to G, chromosome 5 at 135,424,863 bp
  • T to G, chromosome 5 at 143,173,636 bp
  • C to A, chromosome 5 at 144,786,708 bp
  • G to A, chromosome 6 at 139,768,710 bp
  • C to T, chromosome 7 at 16,947,043 bp
  • T to A, chromosome 7 at 25,683,299 bp
  • T to C, chromosome 7 at 27,404,253 bp
  • T to A, chromosome 7 at 27,910,957 bp
  • C to A, chromosome 7 at 30,296,873 bp
  • A to T, chromosome 7 at 48,643,618 bp
  • T to A, chromosome 7 at 80,595,794 bp
  • T to C, chromosome 7 at 106,824,197 bp
  • G to A, chromosome 8 at 3,453,165 bp
  • A to T, chromosome 8 at 22,642,303 bp
  • G to C, chromosome 8 at 71,369,613 bp
  • A to T, chromosome 8 at 83,249,545 bp
  • G to T, chromosome 8 at 123,246,824 bp
  • A to G, chromosome 9 at 44,948,024 bp
  • C to G, chromosome 9 at 105,862,801 bp
  • A to G, chromosome 9 at 114,330,504 bp
  • T to C, chromosome 10 at 4,089,392 bp
  • T to C, chromosome 10 at 42,196,587 bp
  • T to C, chromosome 10 at 42,572,769 bp
  • C to G, chromosome 10 at 59,049,448 bp
  • A to G, chromosome 10 at 75,721,532 bp
  • A to T, chromosome 10 at 116,113,228 bp
  • A to G, chromosome 10 at 128,018,024 bp
  • T to A, chromosome 11 at 29,130,887 bp
  • A to G, chromosome 11 at 86,215,545 bp
  • C to T, chromosome 11 at 105,390,239 bp
  • T to A, chromosome 12 at 78,880,043 bp
  • A to T, chromosome 12 at 80,109,675 bp
  • T to C, chromosome 12 at 104,151,711 bp
  • T to A, chromosome 13 at 13,696,761 bp
  • A to G, chromosome 13 at 21,981,814 bp
  • T to A, chromosome 13 at 27,574,057 bp
  • T to C, chromosome 13 at 67,591,255 bp
  • C to A, chromosome 13 at 102,738,256 bp
  • A to G, chromosome 14 at 55,887,066 bp
  • G to A, chromosome 15 at 55,072,006 bp
  • A to T, chromosome 15 at 76,900,936 bp
  • T to A, chromosome 15 at 100,151,184 bp
  • C to T, chromosome 17 at 27,996,019 bp
  • A to T, chromosome 17 at 46,313,804 bp
  • A to G, chromosome 18 at 60,270,434 bp
  • T to C, chromosome 19 at 6,351,316 bp
  • A to T, chromosome 19 at 24,397,137 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5908 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044105-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.