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Strain Name:
C57BL/6J-MtgxR5911Btlr/Mmmh
Stock Number:
044108-MU
Citation ID:
RRID:MMRRC_044108-MU
Other Names:
R5911 (G1)
Major Collection:

Strain Information

Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: Fam3c, D6Wsu176e, Ilei
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Fgfr-1, Hspy, Eask, FGFR-I, Fr1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Pelp1
Name: proline, glutamic acid and leucine rich protein 1
Synonyms: 4930563C04Rik, MNAR
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75273
Homologene: 8664
Rad23b
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: mHR23B, 0610007D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19359
HGNC: HGNC:9813
Homologene: 37704
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 44,754,374 bp
  • C to A, chromosome 1 at 118,506,908 bp
  • T to C, chromosome 1 at 178,330,172 bp
  • G to A, chromosome 1 at 191,568,407 bp
  • T to C, chromosome 2 at 21,369,121 bp
  • A to T, chromosome 2 at 28,076,689 bp
  • T to A, chromosome 2 at 44,752,064 bp
  • C to T, chromosome 2 at 88,124,683 bp
  • A to T, chromosome 2 at 112,908,487 bp
  • T to A, chromosome 2 at 121,095,973 bp
  • C to T, chromosome 2 at 128,596,074 bp
  • C to T, chromosome 3 at 124,556,731 bp
  • C to T, chromosome 4 at 46,629,912 bp
  • T to A, chromosome 4 at 55,370,474 bp
  • T to C, chromosome 4 at 106,668,043 bp
  • C to T, chromosome 4 at 109,422,971 bp
  • A to C, chromosome 5 at 91,074,693 bp
  • A to T, chromosome 5 at 114,232,890 bp
  • A to T, chromosome 5 at 137,457,912 bp
  • T to A, chromosome 5 at 145,582,539 bp
  • T to C, chromosome 6 at 22,328,561 bp
  • T to A, chromosome 6 at 22,339,300 bp
  • C to A, chromosome 6 at 57,431,789 bp
  • T to C, chromosome 6 at 69,523,987 bp
  • T to C, chromosome 6 at 73,468,691 bp
  • T to A, chromosome 6 at 118,084,374 bp
  • C to T, chromosome 6 at 136,722,442 bp
  • T to C, chromosome 6 at 146,312,943 bp
  • G to T, chromosome 7 at 19,375,892 bp
  • A to T, chromosome 7 at 103,979,708 bp
  • T to A, chromosome 7 at 108,286,398 bp
  • T to A, chromosome 7 at 108,755,675 bp
  • A to G, chromosome 8 at 25,519,309 bp
  • T to C, chromosome 8 at 25,666,076 bp
  • A to G, chromosome 8 at 95,074,126 bp
  • G to A, chromosome 8 at 123,500,039 bp
  • T to C, chromosome 9 at 19,319,149 bp
  • C to A, chromosome 9 at 42,591,424 bp
  • G to T, chromosome 10 at 4,558,551 bp
  • C to T, chromosome 10 at 112,165,686 bp
  • T to A, chromosome 10 at 128,399,943 bp
  • C to T, chromosome 11 at 70,396,914 bp
  • T to A, chromosome 11 at 73,516,525 bp
  • T to A, chromosome 11 at 87,196,837 bp
  • T to A, chromosome 11 at 99,016,465 bp
  • T to C, chromosome 11 at 120,377,132 bp
  • A to T, chromosome 12 at 51,802,252 bp
  • C to T, chromosome 12 at 52,518,742 bp
  • A to G, chromosome 12 at 69,256,251 bp
  • A to T, chromosome 12 at 71,069,973 bp
  • A to T, chromosome 12 at 85,268,455 bp
  • A to G, chromosome 12 at 105,726,212 bp
  • T to A, chromosome 13 at 95,432,056 bp
  • T to C, chromosome 13 at 100,809,092 bp
  • A to G, chromosome 14 at 30,890,655 bp
  • A to G, chromosome 14 at 70,079,448 bp
  • T to C, chromosome 15 at 74,705,768 bp
  • A to G, chromosome 15 at 83,502,281 bp
  • C to A, chromosome 15 at 84,701,434 bp
  • A to G, chromosome 16 at 18,066,734 bp
  • A to G, chromosome 16 at 20,638,760 bp
  • T to A, chromosome 16 at 20,728,796 bp
  • T to C, chromosome 16 at 32,959,463 bp
  • T to C, chromosome 17 at 24,600,387 bp
  • G to C, chromosome 17 at 38,641,042 bp
  • T to A, chromosome 17 at 74,387,063 bp
  • A to T, chromosome 18 at 40,530,852 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5911 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.